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Atorcal 20mg is used in the treatment of lipid metabolism disorders. The drug helps to reduce cholesterol and LDL-don levels in cases that do not respond to diet.
1. Uses of Atorcal 20mg
Atorcal 20mg medicine has the main active ingredient is Atorvastatin, which belongs to the Statin group. Atorvastatin is a competitive inhibitor of HMG - CoA reductase, preventing the conversion of HMG - CoA to mevalonate, which is a precursor of cholesterol. Since then Atorvastatin has the effect of inhibiting cholesterol biosynthesis, reducing cholesterol in liver cells and increasing cholesterol transport from the blood to the liver. The result is a decrease in blood cholesterol levels. The drug also helps reduce levels of LDL cholesterol, a type of low-density lipoprotein, which slows the progression of coronary heart disease. Unlike other drugs in the Statins class, Atorvastatin can also help lower blood triglyceride levels. However, at normal doses, the enzyme HMG - CoA reductase is not completely inhibited, so there is still enough mevalonic acid precursor for many basic metabolic processes of the body.
2. Indications and contraindications when taking Atorcal 20 mg
The drug is indicated in the following cases:
Adjunctive therapy in dietary therapy to reduce levels of total cholesterol, low-density lipoprotein (LDL - C), apolipoprotein B and triglycerides (TG) ) when high. Helps increase high-density lipoprotein (HDL - C) in patients with primary hypercholesterolemia and mixed lipid metabolism disorders. Treatment of primary dysbeta-lipoproteinemia, but inadequate response to dietary measures. Treatment helps to lower total cholesterol and LDL-C in patients with hereditary hypercholesterolemia as adjuncts to other lipid-lowering treatments. As an adjunct to diet therapy to reduce total cholesterol, LDL-Cho (bad cholesterol) and apolipoprotein B in both boys and girls after the first menstrual period, ages 10 to 17 with high cholesterol. Cases of contraindications when using Atorcal:
Hypersensitivity to Atorvastatin, HMG-CoA reductase inhibitors or other ingredients in the drug. Patients with active liver disease or unexplained persistent elevations in serum liver enzymes. Women who are pregnant and breastfeeding.
3. Dosage and how to use Atorcal 20mg
How to use: Take the medicine directly with water. Atorvastatin can be taken once a day at any time of the day, with or without food.
Dosage:
Adults: The starting dose is usually 10 to 20 mg once daily. Treatment should be started with the lowest dose at which the drug has a therapeutic effect. Then, if necessary, the dose can be adjusted according to individual needs and responses. Dose changes are made by increasing the dose at intervals of not less than 4 weeks, during which adverse drug reactions must be monitored. A maximum dose of about 80 mg/day can be used, but close monitoring is required for side effects. Children with hyperlipidemia 10 to 17 years of age: The recommended starting dose of Atorvastatin is 10 mg/day, with a maximum dose of 20 mg/day. Doses above 20 mg/day have not been studied in patients of this age. Dosage should be varied depending on the goal of treatment and should be started with the lowest effective dose. Dosage adjustments similar to those in adults must be made at intervals of 4 weeks or more. Renal Impairment: Renal impairment has no effect on plasma concentrations or lipid-lowering effects of atorvastatin, and therefore no dose adjustment is required for patients with impaired renal function. 4. Undesirable effects when taking Atorcal Atorvastatin is a well-tolerated oral drug, side effects are usually mild and transient. Possible side effects such as:
Common include diarrhea, constipation, flatulence, abdominal pain, nausea and vomiting may occur in about 5% of patients; headache, dizziness, blurred vision, insomnia, weakness, memory loss, confusion; muscle pain, joint pain; Liver enzyme elevations are asymptomatic and are usually reversible upon discontinuation of the drug. Less commonly, muscle weakness, increased plasma creatine phosphokinase (CPK) levels, skin rash, nasopharyngitis, sinusitis, cough, increased glycemic index, increased HbA1c. Rare: Myositis, rhabdomyolysis, may lead to acute renal failure secondary to myoglobinuria. 5. Notes when taking Atorcal 20mg It is necessary to inform the doctor about the history of allergies and medical conditions, if any. To minimize the risk of side effects. Before starting treatment with Atorvastatin, care should be taken to exclude secondary causes of dyslipidemia and measure lipids to confirm the disease. Patients should be on a low cholesterol diet before starting Atorvastatin if there is no response to the drug and after taking the drug, they must continue to maintain this reduced fat diet for the duration of treatment. During treatment, it is recommended to measure the blood fat index and evaluate the side effects of the drug. Do not adjust your dose without your doctor's approval. Dose adjustment should be done slowly, without excessive dose escalation to limit the risk of side effects. During treatment with HMG-CoA inhibitors, if creatine kinase side effects are increased, myositis occurs, or serum liver enzyme levels are increased 3 times the normal limit, the dose should be reduced or Stop treatment for follow-up. When using the drug, caution should be exercised in patients with liver dysfunction, a history of liver disease, patients with heavy alcohol consumption. It can interact with some medications, so tell your doctor what medications you're taking. Some drugs need attention such as macrolide antibiotics, anticoagulants, contraceptives, Digoxin... In addition to the diet, you should follow a suitable lifestyle such as regular exercise, drinking plenty of water. To improve the effectiveness of treatment, reduce the dose of drugs put into the body. The above are the uses and notes to use when using Atorcal 20mg. This is a drug to be used under the prescription of a doctor, you should not use it on your own. Any drug can have adverse effects on the body, so use it only when needed.
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