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Asclera is an intravenous medication used to treat small varicose veins of the lower legs, large inactive veins, accessory veins as well as varicose veins visible above and below the knee. .
1. What is Asclera?
Asclera (Polidocanol) is a prescription medication that is given by injection into a vein. Structural formula C12H25 (OCH2CH2).
Asclera to treat spider veins and larger veins that are dilated (called reticular veins) by destroying the blood vessel wall. Blood flow will be redirected to other healthy veins. It is a type of medicine called a sclerosing agent.
Asclera injection must be performed directly by a physician.
Asclera is formulated as a 0.5% and 1% solution.
2. Indications for the use of Asclera
Uncomplicated spider veins (diameter ≤1 mm). Uncomplicated reticular varices (1 to 3 mm in diameter) of the lower extremities.
3. Contraindications to the use of Asclera
Asclera is contraindicated in patients with known allergy (anaphylaxis) to polidocanol and in patients with acute thromboembolic disease.
4. Mechanism of action
Asclera has a damaging effect on the vascular endothelium. When administered, Asclera causes local damage to blood vessels. After endothelial injury, platelets aggregate at the site and attach to the venous wall causing obstruction. Finally, the blood vessel is replaced by fibrous connective tissue.
5. Dosage and usage
Dosage:
For spider veins (veins with diameter ≤1mm), use Asclera 0.5%. For reticular veins (veins with a diameter of 1 to 3 mm), use Asclera 1%. Use 0.1 to 0.3 mL per injection and no more than 10 mL at a time. Use a syringe (glass or plastic) with a fine needle (size 26 or 30-gauge). Inject the drug solution slowly How to use:
For intravenous use only. Asclera into the venous lumen. Apply only gentle pressure during injection to prevent vein rupture. It is recommended to walk about 15-20 minutes immediately after treatment, avoid heavy exercise for the first week, avoid prolonged exposure to the sun, avoid long flights, hot tub baths or saunas. Wear stockings to maintain compression for 2 to 3 days after spider vein treatment and for 5 to 7 days for reticular vein to reduce the risk of deep vein thrombosis. Repeat treatment may be necessary if the degree of varicose veins requires more than 10mL. These treatments should be spaced 1 to 2 weeks apart.
6. Complications and side effects when using drugs
Bleeding, blistering, burning, cold, skin discoloration. Feeling of pressure, rash, infection, inflammation, itching. Lumps, numbness, pain, rash, redness, scarring, soreness. Anaphylaxis . Tissue necrosis, which may occur after extravasation. Injection into the artery causes necrosis, ischemia. Perivascular injection causes pain.
7. Drug interactions
No drug interactions have been studied with Asclera.
8. Pros and cons of Asclera . injection
Advantages:
Asclera injection is a highly effective, minimally invasive treatment procedure. Loss of the network of blood vessels in the form of a grid, which is unsightly, helps patients to be more confident. Cons:
Can be painful. Requires compression bandages, limiting strenuous activities for the first few weeks. Above is the treatment of Asclera drug. You need to use the drug in the correct dosage, as directed by the doctor, absolutely do not buy and use the drug on your own to protect the best health.
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Reference sources: drugs.com, holevn.org
