Uses of melanov m

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1. What are the effects of melanov-m?

The drug melanov-m is a class of endocrine hormone drugs, with the main ingredients being gliclazide 80mg and metformin hydrochloride 500mg. Among them, gliclazide is a hypoglycemic, antidiabetic sulfamide that lowers blood sugar by stimulating insulin secretion from the beta cells of the islets of langerhans. Gliclazide has a single dose of 40-120mg, causing cmax from 2.2-8mg/l in 2-8 hours. Unstable concentrations will be reached after 2 days of use with the above dosage. Taking gliclazide with food reduces cmax and slows tmax. The volume of distribution is low due to high serum protein binding. Gliclazide has a half-life that varies from 8.1 to 20.5 hours after a single dose. Gliclazie is metabolised primarily to seven metabolites and is mainly excreted in the urine. Most of the metabolites are carboxylic acid derivatives, 10-20% are excreted in the feces and 60-70% of the dose is excreted in the urine.
In addition, metformin is a biguanide with antihyperglycemic effects, lowering basal and postprandial plasma glucose. Metformin has an oral bioavailability of 50-60%, absorption from the gastrointestinal tract is complete after 6 hours and rapidly distributed in the body after absorption. 95% of absorbed metformin is eliminated in the initial phase with a half-life of 6 hours and the remaining 5% is eliminated in the terminal phase with a half-life of 20 hours. Metformin is not bound to plasma proteins, 40-60% of a dose is detected unchanged in the urine and another 30% is detected as unchanged in the faeces.
The drug melanov-m is effective in the treatment of non-insulin dependent diabetes mellitus, diabetes mellitus with or without obesity in adults.
Besides the above uses, melanov-m may also be used to treat some other conditions that are not listed above. Therefore, before using the drug, consult your doctor for advice and effective use of the drug.

2. How to use the drug melanov-m

The drug melanov-m is in the form of tablets, so it can be taken on an empty stomach or on an empty stomach. Patients should take the medicine with a full glass of water to avoid stomach irritation. Dosage of the drug melanov-m will depend on the medical condition and age of the patient. The usual dose is 1-2 tablets/time, taken 1-2 times a day with meals, the maximum dose is 4 tablets/day.
Use melanov-m regularly to get the most benefit from it. To use the drug safely, patients should take melanov-m exactly as directed by the doctor, do not use more than the recommended dose, smaller or longer than indicated. Absolutely do not arbitrarily increase the dose of the drug or abuse the drug for too long for a long time. This not only makes the condition better, but also increases the risk of unwanted effects.

3. Undesirable effects when using the drug melanov-m

Some unwanted effects that may occur when using melanov-m include:
Nausea Diarrhea Stomach pain Constipation Metallic taste in the mouth Rash Itching Urticaria Erythema Headache Dizziness Decreased absorption of vitamin B12 and folic acid when taking metformin for a long time Before prescribing the drug, doctors always weigh the benefits and effectiveness of the drug melanov-m more than the risk of side effects. However, in some cases, when taking melanov-m, unwanted effects may still occur. Therefore, when unusual symptoms occur, especially when a severe allergic reaction occurs with accompanying signs such as difficulty breathing, severe dizziness, rash, swelling or itching of the face, throat, tongue,... In this case, the patient should immediately notify the medical staff for immediate intervention.

4. Some notes when using melanov-m

Some notes when using melanov-m include:
Tell your doctor about a history of allergy to melanov-m or any other allergies. Melanov-m may contain ingredients that are inactive and could cause allergic reactions or other serious problems. Report any medications you are taking including prescription and nonprescription drugs, herbs and supplements, foods, or preservatives. Melanov-m is contraindicated in patients with insulin-dependent diabetes mellitus, renal or hepatic impairment, alcoholics, non-insulin-dependent diabetes mellitus with serious complications due to ketoacidosis or acidosis, pre-coma or coma. diabetic coma, recent surgery, infection or trauma, chronic obstructive pulmonary disease, heart failure, coronary artery disease, peripheral vascular disease, and pregnant women. Adjust dosage based on blood and urine glucose levels for the first few months. However, there are some reports of lactic acidosis in patients with liver or kidney disease. Hypoglycaemia can occur in patients with reduced dietary intake, after an overdose or after heavy exercise, trauma, or stress. Symptoms of hypoglycemia can be treated by prescribing the patient's meal plan and stopping the drug as soon as signs and symptoms of hypoglycaemia occur. If a dose is missed, the patient should take the missed dose as soon as possible. However, if the time you remember is close to the time of your next dose, skip the missed dose and continue taking the medicine as scheduled. Do not arbitrarily add more than double the dose of the drug than the treatment regimen. Overdose of the drug melanov-m can cause serious symptoms affecting health.

5. Drug interactions

Drug interactions can reduce the effect of the drug melanov-m, or increase the effect of unwanted effects. Tell your doctor about all other medicines you are taking including vitamins, over-the-counter medicines, prescription drugs, and herbal products. Do not stop, start, or change the dose of any medicine without your doctor's consent without your doctor's consent.
Some drugs that may interact with melanov-m include:
Diuretics Barbiturate Rifampicin Phenytoin Corticosteroids Estrogen Estroprogestogen Purified Progestogan Salicylate Phenylbutazone Sulphonamide Beta Blocker Clotibric Acid Vitamin K Antagonist Allopurinol Theophulline Caffeine Inhibitors MAO preparation Miconazole Perhexiline Cimetidine Gliclazide Acarbose

6. How to store melanov-m

Store melanov-m at room temperature, protected from light and away from moisture. Do not store melanov-m in a humid place or in the freezer. Different medicines will have different storage methods, so read the melanov-m storage instructions carefully on the packaging, or ask your pharmacist. Keep melanov-m out of the reach of children and family pets. When the medicine has been damaged and cannot be used anymore or has expired, dispose of the medicine according to the correct procedure. Do not arbitrarily dispose of melanov-m into the environment such as water pipes or toilets unless requested. Please consult with your environmental waste company or pharmacist on how to safely dispose of melanov-m to help protect the environment.
In summary, the drug melanov-m is effective in the treatment of non-insulin dependent diabetes mellitus, diabetes mellitus with or without obesity in adults. However, melanov-m can cause some unwanted effects and drug interactions, so tell your doctor what medicines you are taking to reduce the risk of side effects and at the same time increase your chances of getting worse. effective for treatment.
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