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Macetux 200 is one of the drugs used to definitively treat the symptoms of the respiratory tract being encountered, helping to keep the respiratory tract clear of bacteria. To better understand what drug Macetux 200 is? What are the uses of Macetux 200? What is the correct way to drink? Features to pay attention to when using? The article below will help you better understand the drug Macetux 200.1. What are the uses of Macetux 200?
What is Macetux 200? Macetux 200 contains acetylcysteine with a strength of 200mg, which is a drug that dissolves mucus. It is used to treat disorders of bronchial secretions, especially in acute bronchial disorders, such as acute bronchitis and exacerbations of chronic lung disease.
There are other effects of the drug that are not listed on the drug label but are approved, then your doctor can prescribe it for you. Therefore, it should only be used as prescribed by a doctor.
Indications for use:
Mucolytic in bronchiectasis, bronchial asthma, acute and chronic pneumonia with increased mucus secretion.
2. Dosage and usage of Macetux 200
Mucolytic in adjuvant therapy for patients with abnormal mucus secretion, viscous mucus disease or in diseases with thick mucus such as acute and chronic bronchitis. Unless otherwise directed, the usual dose is as follows: Adults and children over 7 years of age: 200mg x 2-3 times/day. Children 2-7 years old: 200mg x 2 times/day. Children under 2 years old: 100 mg x 2 times/day. Antidote in the treatment of paracetamol overdose. The initial dose is 140 mg/kg, followed by a dose of 70 mg/kg every 4 hours and a total of 17 doses. Acetylcysteine is most effective when taken within 8 hours of a paracetamol overdose. After this time, the effect will decrease. However, starting treatment more than 24 hours later may still be beneficial.
3. Contraindications of the drug Macetux 200
Acetylcysteine 200 mg Powder for Oral Solution must not be used when:
Hypersensitivity to the active substance, other chemically similar substances (e.g. carbocisteine, erdosteine or mecysteine) or to any of the excipients . Phenylketonuria is present, because the product contains aspartame.
4. Harmful interactions of the drug Macetux 200
4.1. Drug Interactions At least 2 hours between oral tetracycline and oral Acetylcysteine Acetylcysteine should not be used concurrently with cough suppressants because it can cause severe mucus congestion due to decreased cough reflex. When taking drugs with certain drugs, it is advisable to consult a doctor. Acetylcysteine may potentiate the vasodilator effect and inhibit platelet aggregation of nitroglycerin. Acetylcysteine is a reducing agent and should not be used in combination with some oxidizing agents. 4.2. Drug interactions Macetux 200 with food and drinks When using the drug with foods or alcohol, beer, tobacco... because in those foods and drinks containing other active ingredients, it can affect antagonism or synergism with the drug. Read the instructions for use carefully or consult your doctor or pharmacist about taking Macetux 200 with food, alcohol and tobacco.
4.3. Precautions for use and special warnings. Patients with bronchial asthma should be closely monitored during treatment; if bronchospasm occurs, treatment with Acetylcysteine 200 mg Powder for Oral Solution should be discontinued immediately. Administration of acetylcysteine, especially at the beginning of treatment, can liquefy bronchial secretions and increase their volume. If the patient is unable to effectively expectorate sputum, to avoid retention of secretions, tracheal aspiration and postural drainage should be performed. There are no studies on the efficacy and safety of acetylcysteine 200mg three times daily in the adolescent population. However, mild to severe adverse reactions have been reported with the use of IV acetylcysteine in adults and adolescents. This medicine contains sorbitol. Patients with rare genetic problems and fructose intolerance should not take this medicine. This medication contains aspartame, which is a source of phenylalanine. This can be harmful for people with phenylketonuria. This medication contains a coloring agent called sunset yellow (E110), which can cause an allergic reaction. Acetylcysteine may interfere with the colorimetric assay for the determination of salicylates. Acetylcysteine may interfere with urine ketone testing. When opening the package, the powder may have a sulfur smell. This is a normal characteristic of the active substance. When water is added, the solution will have a citrus smell.
5. The side effects of the drug Macetux 200
Acetylcysteine has a wide safety margin.
Common: Nausea, vomiting.
Uncommon: Drowsiness, headache, tinnitus. Inflammation of the mouth, a lot of runny nose. Rash, hives.
Rare: Clinically obvious bronchospasm due to acetylcysteine, but can still occur with all forms of acetylcysteine containing drugs. Bronchospasm with systemic anaphylactoid reactions. Fever, chills.
It should be noted that the above is not a complete list of all the side effects of Macetux 200. In the process of use, other side effects may occur that have not been shown or have not been studied. If there are any other side effects of Macetux 200 that are not specified in the instructions for use, consult your doctor or pharmacist.
Instructions on how to manage unwanted effects
Using diluted acetylcysteine solution can reduce the possibility of drug-induced vomiting. Anaphylaxis should be treated immediately with subcutaneous adrenaline injection (0.3 - 0.5 ml of 1/1000 solution), 100% oxygen, intubation if necessary, intravenous fluids to increase plasma volume. , inhaled beta-adrenergic agonist if bronchospasm, intravenous 500 mg hydrocortisone or 125 mg methylprednisolone.
Can inhibit hypersensitivity reactions to acetylcysteine including generalized erythema, pruritus, nausea, vomiting, dizziness, by pre-administration of antihistamines. It has been suggested that hypersensitivity is due to a pseudoallergic mechanism based on histamine release rather than from immunological causes. Because hypersensitivity reactions have occurred in up to 3% of people who received intravenous acetylcysteine to treat paracetamol overdose, physicians should pay attention to using antihistamines to prevent such reactions.
6. Macetux 200 drug interactions with other drugs
Acetylcysteine is a reducing agent so it is not suitable for oxidizing agents. Concomitant use of other cough suppressants or any other drug that reduces bronchial secretions during treatment with acetylcysteine is contraindicated. Acetylcysteine reacts with some metals, especially iron, nickel, copper and with rubber. Contact with these substances should be avoided. Do not use foggers with metal or rubber components. Acetylcysteine sodium solution is physically and/or chemically incompatible with solutions containing penicillin, oxacillin, oleandomycin, amphotericin B, tetracycline, erythromycin lactobionate, or ampicillin sodium. When one of these antibiotics is to be administered in an aerosol form, the drug must be nebulized separately. The acetylcysteine solution is also physically incompatible with iodized oil, trypsin and hydrogen peroxide.
7. Note when using the drug Macetux 200
Patients with reduced renal function: dosage adjustment is required, especially during combination therapy with other antihypertensive agents. Within 4 weeks, if no results are achieved, the dose should be increased or another antihypertensive agent should be considered. Patients with suspected renal artery stenosis: serum creatinine should be measured before starting treatment. Patients at risk of asthma must be closely monitored, if acetylcysteine is used for people with a history of allergies; If bronchospasm is present, a bronchodilator nebulizer such as salbutamol (a short-acting, selective beta-2 adrenergic drug) or ipratropium (an antimuscarinic agent) must be used and acetylcysteine should be discontinued immediately. During treatment with acetylcysteine, a large amount of thin sputum may appear in the bronchi, which must be aspirated to remove if the patient's ability to cough is reduced. Pregnancy Treatment of paracetamol overdose with acetylcysteine in pregnant women is effective and safe, and has the potential to prevent fetal and maternal hepatotoxicity. Breast-feeding The drug is safe for breast-feeding women.
Pregnancy period:
General note during pregnancy: Drugs used during pregnancy can cause adverse effects (miscarriage, teratogenicity, fetal malformation...) to any stage. any stage of pregnancy, especially the first trimester. Therefore, it is best not to use the drug for pregnant women. In the case of mandatory use, it is necessary to consult carefully with your doctor, pharmacist before making a decision.
Lactation period:
General note during lactation: The drug can be passed to the baby through breastfeeding. It is best not to or limit the use of the drug during breastfeeding. Many drugs have not yet fully determined the effects of the drug during this period, so mothers need to carefully read the instructions for use and consult with doctors and pharmacists before deciding to use the drug.
Effects on ability to drive and use machines:
No studies on the effects on the ability to drive or use machines have been performed. Acetylcysteine 200 mg Powder for Oral Solution has not been determined to have any effect on the ability to drive and use machines.
8. Overdose, missed dose and treatment
Overdose:
In case of overdose requiring emergency, family members need to bring the prescription/vial of medicine the victim has taken. In addition, family members also need to know the height and weight of the victim to notify the doctor.
Missed dose:
Usually medicines can be taken in 1-2 hours longer than prescribed in the prescription. Unless there is a strict rule about the time of use, the medicine can be taken a few hours after forgetting. However, if the time is too far from the time you need to drink, you should not take it, which can be dangerous for the body. It is necessary to strictly adhere to or consult a doctor before making a decision.
Preserve Macetux 200
In a cool place, the temperature does not exceed 30 degrees Celsius, protect from light.
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