Uses of Lorista 50mg

This is an automatically translated article.

1. What is Lorista 50mg?

Losrista drug is prepared in the form of film-coated tablets with a content of 50mg/tablet, with the main ingredients including:
Active ingredient: Potassium losartan 50mg Excipients: Cellactose, corn starch, modified starch, micro-cellulose crystalline, Silica colloidal anhydrous, Hypromellose, Magnesium stearate, Talc, Titanium dioxide E 171, Propylene glycol. Just enough for 1 10 mg tablet. Pharmacodynamics
The main effects of Angiotensin II receptors include vasoconstriction, renal sodium and water retention, and stimulation of the Noradrenalin sympathetic system.
Potassium losartan is an active ingredient that helps lower blood pressure through the mechanism of antagonizing the AT1 Angiotensin II receptor. Specifically, potassium losartan competes for the binding site of Angiotensin II receptors located on the muscles surrounding blood vessels. Once Angiotensin II does not bind to the receptors, they will not manifest the above effects, so blood vessels are dilated, heart rate decreased, sodium and water reabsorption decreased, resulting in lower blood pressure. .
Potassium losartan may reduce the risk of cardiovascular death, myocardial infarction, or stroke in hypertensive patients with left ventricular hypertrophy. In addition, potassium losartan helps to protect kidney function in patients with type 2 diabetes with proteinuria.

2. What are the effects of Lorista 50mg?

Lorista 50 is indicated for the treatment of the following subjects:
People with mild to moderate hypertension. Used alone or in combination with other antihypertensive agents such as thiazide diuretics. People with high blood pressure cannot tolerate ACE inhibitors. Support in the treatment of heart failure (under investigation).

3. Contraindications of Lorista 50mg:

Hypersensitivity to any ingredient of the drug. History of allergy to Potassium losartan. History of allergy to other drugs of the class of receptor blockers. Young people < 18 years old. Pregnant or lactating women.

4. Dosage and how to use Lorista 50mg:

Dosage of Lorista 50 is usually indicated and adjusted according to the condition and blood pressure response of the drug.
Adults
Usual starting dose: Take 1 tablet (50mg)/time x 1 time/day. Initial dose for people with signs of loss of intravascular fluid, impaired liver function or people taking diuretics: Take 1⁄2 tablets (25mg)/time x 1 time/day. Maintenance dose: Take 1-2 tablets (25-100mg) x 1-2 times/day. Usually no dose adjustment is required for the elderly or people with impaired renal function
Every 1 to 2 months, the dose must be adjusted if the blood pressure cannot be controlled with the used dose.
How to use
Can take the medicine both when hungry or full.
Use the correct dose based on the doctor's prescription and instructions.

5. Notes when using Lorista 50mg:

Encountered side effects
Treatment with Lorista 50 in high doses or for a long time, can cause side effects such as:
Common: Low blood pressure, insomnia, dizziness, cough, sinusitis, swelling Blood in the nose, diarrhea, indigestion. Hyperkalemia, hypouricemia, decreased hemoglobin and blood hematocrit. Back pain, fatigue, muscle and bone pain. Uncommon: Neuropsychiatric disorders such as depression, anxiety, ataxia, dizziness, migraine, insomnia, fever. Skin manifestations such as alopecia, dermatitis, itching, urticaria, dry skin, erythema. Respiratory symptoms such as bronchitis, pneumonia, rhinitis, airway obstruction, sore throat, sweating, nosebleeds. Conjunctivitis of the eye, impaired vision, hearing and tinnitus. Cardiovascular manifestations such as orthostatic hypotension, chest tightness, sinus bradycardia, tachycardia, edema. Symptoms on the urinary system such as frequent urination, nocturia, decreased sex drive, urinary tract infections, slight increase in creatinine and urinary urea levels. On the digestive system including anorexia, flatulence, nausea, vomiting, gastritis, increased parameters of liver function assessment. Gout. Other effects such as decreased sex drive, sweating. Should stop the drug as soon as detecting the above symptoms after using Lorista 50 and promptly notify the treating doctor or immediately go to the nearest medical facility for treatment.
Attention when using the drug on subjects
Caution when using Lorista 50 in the following cases: Patients who are dehydrated, those who are being treated with diuretics or those with risk factors that easily lead to hypothermia. Blood pressure should be reduced in dose and should be closely monitored. Patients with severely impaired liver function should use low doses. Patients with unilateral or bilateral renal artery stenosis, who have only one kidney, are prone to side effects such as elevation of creatinine and blood urea, so special supervision is required during treatment. Pregnancy: Current animal studies indicate that the active substance losartan potassium, based on its mechanism of action on the Renin-Angiotensin system, can cause damage to the developing fetus, reduce renal perfusion, and and increased risk of fetal death. Do not or stop using Lorista 50 when pregnant. Lactation: There is currently no evidence that losartan potassium can be excreted in human milk. However, it is necessary to evaluate the benefits and harms of using the drug in these subjects. Drivers or machine operators should use caution when using Lorista 50mg because it can cause dizziness and loss of concentration while working.

6. Lorista 50mg drug interactions:

Interactions with other drugs
Low-dose diuretics such as Hydrochlorothiazide used in combination with Lorista 50 may increase the effectiveness of blood pressure control. Avoid combining the drug with potassium-sparing diuretics, or preparations containing potassium because it can increase blood potassium. Concomitant use of Lorista 50mg and NSAIDs may lead to impaired renal function, including acute renal failure. In cases where the co-administration of these two drugs is mandatory, periodic monitoring of renal function is required. Fluconazole is an active P450 2C9 inhibitor that can increase the concentration of Lorista 50mg in the blood, thereby increasing the effect of the drug. In contrast, Rifampin, Phenobarbital and Ketoconazole reduced the effect of Lorista 50 mg when used concurrently. Lorista 50mg may increase lithium levels by an unspecified mechanism. Thereby increasing the physical impact, side effects and toxicity of Lithium. Lithium concentration should be monitored in case of mandatory general use.

7. Preservation of drugs

The drug is stored in a tightly closed container, at room temperature below 30°C. The storage place must be dry, away from moisture. Avoid direct sunlight. Medicines should be kept out of reach of children. The above is general information and notes when using Glomoti-M. In order to achieve the best treatment results, patients should carefully read the instructions for use and strictly follow the instructions of the doctor.

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