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Laclomez is an antibiotic used to treat mild to moderate infections. With the main active ingredient is Clarithromycin, information on dosage, usage and side effects of Laclomez will be in the article below.
1. What is Laclomez?
Laclomez is an antibiotic used in the treatment of mild to moderate bacterial infections. Laclomez contains the active ingredient Clarithromycin, a semi-synthetic macrolide antibiotic.
Laclomez is prepared in the form of uncoated tablets, with a package of 1 blister of 10 tablets. Clarithromycin content in each Laclomez tablet is 500mg.
2. What are the effects of Laclomez?
Laclomez has the active ingredient Clarithromycin which belongs to the group of Macrolide antibiotics. The main effect of Clarithromycin is bacteriostatic and only kills bacteria if used in high doses.
Clarithromycin itself is a new generation Macrolide antibiotic, the active ingredient is semi-synthetic from Erythromycin with a methoxy substituent right at the C-6 position of the Macrolide ring. This change helps Clarithromycin to increase antibacterial spectrum, concentration in body tissues, endurance in acidic environment and at the same time reduce side effects on the patient's digestive system.
Laclomez's bacteriostatic mechanism is that Clarithromycin will bind to the 50S ribosomal subunit of bacteria, causing bacteria to inhibit protein synthesis.
Clinically, Laclomez contains Clarithromycin which has an antibacterial mechanism against Gram-positive and negative strains, including the following anaerobes and aerobics: Moraxella (Branhamella) catarrhalis and Legionella spp., Ureaplasma urealyticum, intracellular Mycobacterium avium, Chlamydia spp. , M. leprae, Toxoplasma gondii, Cryptosporidis.
Regarding pharmacokinetics, Laclomez drug is well absorbed from the gastrointestinal tract, bioavailability of the drug after the first high degree of metabolism will be slightly reduced to only 55%. The absorption of Clarithromycin is not affected by food in the stomach, peak blood concentrations are achieved after a single dose of 250 mg.
Regarding the binding and distribution in the body, Laclomez drug is mainly distributed in tissues, so the drug concentration in the tissue is higher than in the serum.
About elimination, mainly excreted in the urine, the rest is excreted in the biliary tract with the amount of drug metabolised in the liver. The half-life of Laclomez with patients taking 250mg x 2 times in 1 day is 3-4 hours, with people taking a dose of 500mg x 2 times in 1 day, this time is 5-7 hours. This time is longer in patients with renal failure.
3. Indications for the use of the drug Laclomez
Laclomez drug with the main compound is Clarithromycin is used in the following cases:
Used as an antibiotic in patients allergic to penicillin, often used in patients with respiratory infections such as tonsillitis, otitis media , sinusitis, chronic bronchitis. Pneumonia caused by Mycoplasma pneumoniae and Legionella. Diphtheria and early stage pertussis. Opportunistic infections caused by Mycobacterium avium complex. Used to treat Helicobacter pylori causing peptic ulcers by using in combination with a drug with a proton pump inhibitor function or an antihistamine H2 receptor antagonist or antibacterial drug. Superinfection caused by Mycobacterium avium or M. avium complex in people with previous HIV infection. Skin and soft tissue infections.
4. Contraindications to the use of Laclomez
Patients with a history of hypersensitivity or allergy to the Macrolide group of antibiotics or the ingredients of Laclomez. Patients who are being treated with the antibiotic Terfenadine, have a history of heart disease or electrolyte disturbances. Patients are taking derivatives such as Ergotamine, Cisaprid, Pimoside.
5. Dosage and way of taking Laclomez
How to use: Laclomez is taken orally and is well absorbed from the gastrointestinal tract, so patients can use the drug before or during and after meals.
Dosage depends on the severity of the disease, the duration of treatment can be from 7-14 days.
Dosage in adults:
Respiratory tract and skin infections: Use each time from 250mg - 500mg / time, 2 times a day. For people with kidney failure, a mild dose of 250mg x 1 time/day or x 2 times/day can be used if the infection is severe. Infections caused by Mycobacterium avium intracellular (MAI): Use 500mg/time, 2 times a day. Treatment of HP infections: Dose 500mg x 3 times/day, used in combination with proton pump inhibitors and other drugs. Dosage in children:
Standard dose: 7.5mg/kg body weight, taken 2 times a day, the maximum dose is 500mg x 2 times a day. Community-acquired pneumonia: 15mg/kg body weight, once every 12 hours.
6. Side effects of the drug Laclomez
Clinical cases that can record side effects of Laclomez are as follows:
Digestion: Loss of appetite, change in taste; Body as a whole: Headache, body fatigue; Skin: Urticaria, rash, itching; Swelling of face and throat, tongue. More severe symptoms of Laclomez that can be seen in patients are abnormal bleeding, dark urine, arrhythmias, hoarseness, peeling and blistering of the skin.
The side symptoms are severe or mild depending on the patient's previous allergy to antibiotics or may be due to the dose. If symptoms get worse or do not improve, stop taking Laclomez immediately and tell your doctor.
7. Notes when using the drug Laclomez
In Vietnam, the status of bacteria resistant to Macrolid is increasing rapidly. Therefore, bacteria that are resistant to erythromycin are often also resistant to other macrolides, including clarithromycin. Use with caution in pregnant and lactating patients. Use with caution in patients with impaired renal and hepatic function. Laclomez is an antibiotic of the Macrolide group, designed for use in mild to moderate infections. Laclomez is a prescription drug, patients should only take it as prescribed by a specialist.
