Uses of Idozaxi

This is an automatically translated article.


Idozaxi is an antiviral drug, the main ingredient is Adefovir dipivoxil 10mg. The drug is used in the treatment of chronic hepatitis B in adults with active or persistent elevations in AST, ALT or progressive histopathology. To better understand Idozaxi drug information, you can refer to the article below

1. What is Idozaxi?


Idozaxi drug contains the main ingredient Adefovir dipivoxil 10mg, in addition, the drug also has other ingredients including Dextrose anhydrous, PVP K30 (Polyvinylpyrrolidone), corn starch, magnesium stearate. Adefovir dipivoxil is the oral prodrug of adefovir, which is actively transported into mammalian cells, where it is converted by host enzymes to adefovir diphosphate. Adefovir diphosphate inhibits viral polymerase by competitively binding directly to natural substrates and subsequently by incorporation into viral DNA causing DNA strand termination. Adefovir diphosphate selectively inhibits HBV DNA polymerase at concentrations 12,700 and 10 times lower than those required for selective inhibition of human DNA polymerases. In active and inactive leukocytes, adefovir diphosphate has an intracellular half-life of 12 and 36 hours, respectively. After oral administration of Adefovir dipivoxil was converted to adefovir, 45% of the 10 mg oral dose was recovered in the urine within 24 hours. Adefovir is found in the urine.

2. In which case is Idozaxi used?

Idozaxi is used in the treatment of chronic hepatitis B in adults with evidence of active viral replication and persistent elevations in blood aminotransferases (AST or ALT) or in the presence of advanced histological disease. develop.
This indication for Idozaxi is based on the histological, virological, biochemical and serological responses in adults with chronic hepatitis B with functional HBeAg(+) and HBeAg(-) compensated liver function and in adults with clinical evidence of lamivudine-resistant hepatitis B virus infection in the presence of compensated or decompensated liver function.
Do not use in cases of hypersensitivity to Idozaxi or to any of its ingredients.

3. Dosage - how to take Idozaxi


3.1. How to use Idozaxi is prepared in tablet form, taken orally. You should take the medicine with a full glass of water, food does not affect the effect of the drug, so you can take the medicine before or after eating at a fixed time of the day.
3.2. Dosage of Idozaxi is to be taken under the direction of a doctor or you can refer to the manufacturer's recommended dose below:
Adults: The recommended dose of Idozaxi for chronic hepatitis B patients is functional. Normal renal function is 10 mg/time/day, orally once a day For patients with renal impairment: It is necessary to reduce the drug dose and adjust the interval between doses of Idozaxi based on the patient's creatinine clearance (CC): If CC > 50 ml/min: 10 mg/time/day, 1 time/day If CC is 20 to 49 ml/min: 10 mg/time every 48 hours. If CC is 10 to 19 ml/min: 10mg/time every 72 hours. If CC is less than 10ml/min: there is no recommended dose for this case because the pharmacokinetics of the drug has not been studied in non-dialysis patients with CC <10ml/min. In case of patients on hemodialysis: take the drug every 7 days after dialysis or after cumulative dialysis for a total of 12 hours. Note: Although Idozaxi can be used in patients with liver failure and does not require dose adjustment, you should consult your doctor for the most accurate and complete advice.

4. Undesirable effects of the drug Idozaxi


During the use of Idozaxi, some unwanted effects may occur, including:
On the digestive system: abdominal pain, nausea, indigestion, flatulence and diarrhea. Other common side effects are headache and weakness. On the respiratory system include symptoms such as more cough, sore throat and sinusitis. Skin: Itchy skin, rash. Liver and kidney abnormalities such as increased blood creatinine levels, kidney damage, acute renal failure, and elevated liver enzyme levels. If you experience any of the above undesirable effects or find an abnormality when using the drug, you need to inform your doctor immediately so that he or she can have a timely treatment, sometimes you may have to stop. medication and need medical help.

5. Notes when using Idozaxi


You need to inform your doctor about all the drugs you are taking to avoid possible drug interactions during use, especially drugs that are excreted by the kidneys, toxic drugs. kidney and affect liver enzymes. You may need to stop taking Idozaxi if you have a rapid increase in liver enzyme levels, do an ultrasound or a liver test while taking this medicine. Examination revealed fatty liver, progressive hepatomegaly or lactic acidosis or metabolic acidosis of unknown etiology. Tell your doctor about your medical history and any medical conditions you have, especially any history of liver or kidney disease such as hepatomegaly, hepatitis, cirrhosis, or other risk factors for liver disease. other liver disease; CKD. Your liver function is closely monitored periodically for some time (eg, 12 weeks) after you stop taking adefovir dipivoxil; Assess renal function every 3 months to detect early renal dysfunction. You should be tested for HIV antibodies before starting treatment with Idozaxi or adefovir dipivoxil because the use of adefovir dipivoxil for the treatment of chronic HIV infection in patients with undetected or untreated HIV infection can cause HIV infection. can lead to resistance to HIV. Idozaxi should not be used in children and adolescents under 18 years of age, as the safety and effectiveness of the drug have not been adequately studied in these circumstances. Currently, the manufacturer has not given a recommended dose for patients over 65 years of age. Therefore, you should consult your doctor before using the drug. There is insufficient evidence from studies in pregnant women regarding the safety and potential of mother-to-child transmission of HBV, so you should inform your doctor about your intention to become pregnant or if you are pregnant. will give you appropriate advice, weighing the benefits and risks. In particular, it is necessary to vaccinate children to prevent hepatitis B virus infection at birth. There is no evidence that this medicine passes into breast milk, so you should not breast-feed while using this medicine or medicines that contain adefovir dipivoxil. There have been no reported cases of the drug affecting the ability to drive and use machines, but you should still be careful in these situations. Overdose and treatment: Idozaxi 500mg/day for 2 weeks or 250mg/day for 12 weeks has caused the above digestive disorders and anorexia. When an overdose occurs, it is advisable to monitor for abnormal signs and immediately notify the doctor for timely support. Store Idozaxi in a cool, dry place, at a temperature below 30°C, protected from light. Keep out of reach of young children. Idozaxi is an antiviral drug used in the treatment of chronic hepatitis B when eligible. The use of the drug requires specific instructions from the doctor, absolutely do not arbitrarily use the drug without a prescription. If you have any questions about the information about the drug Idozaxi, you can contact your doctor or pharmacist for complete advice.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.

Share
Patients Stories