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Mizinvir is used to treat chronic hepatitis B virus infection in adults with evidence of viral replication activity and either persistent elevation of serum aminotransferases (ALT or AST) or active tissue disease.1. What is Mizinvir?
Manufacturer: SPM Joint Stock Company.
Packing: Box of 3 blisters x 10 tablets.
Dosage form: Film coated tablets.
Ingredients:
Entecavir 0.5mg. Excipients 1 capsule.
2. Uses of Mizinvir
Entecavir is a synthetic component of purine Nucleotide, which has the ability to fight hepatitis B virus. When the body, it is converted by cells into active Entecavir triphosphate by phosphorylation. This substance inhibits the reverse transcriptase enzyme DNA polymerase of the hepatitis B virus. Therefore, it can prevent the replication of the virus.
The drug is resistant to hepatitis B virus, including some strains already resistant to Lamivudine. In particular, viral resistance to Entecavir has been shown to be very slow. Less than 1% of patients develop drug-resistant symptoms.
Indications:
Mizinvir 0.5mg is commonly used in the treatment of hepatitis B in patients 16 years of age and older who have evidence that the hepatitis B virus is actively replicating DNA in the blood and have elevated ALT and AST levels. high or with histological evidence of liver disease. Entecavir is effective in the treatment of hepatitis B or lamivudine-resistant hepatitis B virus cases.
3. Usage and dosage of Mizinvir
Usage:
For oral use only. Not to be used for any other purpose. Take the medicine with a sufficient amount of water. Do not chew or crush the tablet as it may reduce its bioavailability. Should take the drug on an empty stomach about 2 hours before meals or 2 hours after meals for the best effect. Dosage:
Absolutely follow the doctor's dose instructions. Reference:
People who have never been treated with similar Nucleoside drugs: Take 0.5mg/time/day. Patients with a history of hepatitis B virus infection in the blood while taking Lamivudine or cases of hepatitis B virus resistant to Lamivudine, Telbivudine: Take 1mg/time/day. How to deal with missed dose, overdose:
Missed dose: Take as soon as you remember, as soon as possible. Absolutely do not take a double dose or take two doses close to each other because it can cause an overdose. Overdosage: Limited data are available for overdose. If taking more than the prescribed dose, immediately go to the nearest medical facility for timely monitoring and treatment.
4. Contraindications
Absolutely do not use Mizinvir 0.5mg for:
People who are sensitive or allergic to any ingredient of the drug. Pregnant or lactating women. Persons under 16 years old.
5. Side effects of the drug Mizinvir
According to frequency, the possible side effects when taking the drug are divided into:
Common:
Headache. Dizzy. Insomnia. Vomiting, nausea. Diarrhea. Undigested. Tired. Bloody urine. Increased creatinine and glucose in urine. Increased blood bilirubin. Increase Amylase. Increased Transaminases. Increased Lipase. Uncommon:
Rash. Indigestion stomach. Hair loss. Rare : Anaphylactic reactions.
In addition, other symptoms not listed here may be experienced. If you experience any unusual symptoms, immediately notify a qualified doctor or pharmacist for appropriate instructions.
6. Drug interactions
Possible interactions when taking other drugs concurrently with Mizinvir:
Drugs such as Ganciclovir, Valganciclovir, Ribavirin may increase the effect of Entecavir. Drugs that affect the kidneys or are eliminated by the kidneys may increase the serum concentration of Entecavir or co-administered drugs. Immunosuppressive drugs such as Cyclosporin, Tacrolimus, ... when used in combination affect kidney function. To be safe, inform your doctor about all medications, health foods you are taking and medical history to be considered and to avoid possible adverse interactions as much as possible.
7. Notes when using Mizinvir
Pregnant women and lactating mothers Do not use in these subjects because there are no studies and data on the consequences of taking the drug during pregnancy or lactation. Drivers and machine operators Be careful when driving or operating machinery because you may experience dizziness, headache, etc. when taking the drug. Other special note:
Must regularly monitor liver indicators throughout the time of taking the drug. When used in people with decompensated liver disease there is a high risk of lactic acidosis. Adequate precautions must be taken as Entecavir does not reduce the possibility of transmission of the virus to others. Storage:
Store in a cool, dry place. Keep out of reach of CHILDREN. Avoid placing in damp or direct sunlight.
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