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Hypravas 20 is used in the treatment of hyperlipidemia, prevention of some cardiovascular conditions. So what is the effect of Hypravas 20 and how to use this drug?1. What are the effects of Hypravas 20?
Hypravas 20 is made in the form of tablets, with the main ingredient in each tablet is Pravastatin 20mg. Pravastatin is a lipid-lowering drug belonging to the group of HMG - CoA reductase inhibitors, statins. This active ingredient competitively inhibits HMG-CoA reductase, thereby preventing the conversion of HMG-CoA to mevalonic acid - a precursor of cholesterol.
Pravastatin inhibits cholesterol biosynthesis in the liver and reduces cholesterol in hepatocytes. This in turn stimulates the synthesis of LDL receptors on the hepatocyte membranes, thereby increasing the clearance of LDL from the circulatory system. In addition, Pravastatin also reduces VLDL, triglyceride levels and increases HDL. At normal doses, HMG-CoA reductase is not completely inhibited by the drug, so there is still enough mevalonic acid for many other metabolisms.
Hypravas 20 is indicated in the following cases:
Primary hypercholesterolemia (type IIa, IIb). Primary Prevention: Reduces the risk of cardiovascular death in patients with moderate or severe hypercholesterolemia, but no clinical manifestations, and at high risk for first-time cardiovascular events. Secondary prevention: In patients with a history of myocardial infarction or unstable angina with normal or elevated blood cholesterol to reduce the risk of cardiovascular death. Post-transplant: Reducing hyperlipidemia in patients receiving immunosuppressive drugs after organ transplantation. Hypravas 20 is contraindicated in the following cases:
People with hypersensitivity to any ingredient of the drug. Active liver disease or persistent elevation of serum transaminases above 3 times normal for unknown reasons.
2. Dosage and how to use Hypravas 20
Hypravas 20 is taken once a day, preferably in the evening. Hypravas 20 can be taken with a meal or on an empty stomach. The dose of Hypravas 20 should be according to the doctor's instructions, the recommended dose is as follows:
Hypercholesterolemia: Use a dose of 10-40mg/time/day. The therapeutic effect can be seen in 1 week and at the latest after 4 weeks. Lipid levels should be checked periodically so that the dose can be adjusted if necessary, up to a maximum dose of 40 mg/day. Prevention of cardiovascular disease: Use a dose of 40mg/day. After organ transplantation: Use a starting dose of 20mg/day. Dosage adjustment depends on the response of the lipid index, the dose of Hypravas 20 can be increased to 40 mg/day under the close supervision of the physician. Children and adolescents (8-18 years old) with heterozygous familial hypercholesterolemia: Children 8-13 years old: Use dose 10-20mg/time/day. Children 14-18 years old: Use dose 10-40mg/time/day. Patients with impaired liver function or impaired renal function: Use a starting dose of 10mg/day, adjust the dose according to the response of the lipid index and under the supervision of the physician. Combination treatment of Hypravas 20 with some other drugs:
Combination of Hypravas 20 with a bile acid-binding resin (such as colestyramine, colestipol) will help increase the effectiveness of lowering total cholesterol and LDL - cholesterol. However, Hypravas 20 should be taken 1 hour before or at least 4 hours after taking these drugs. For patients receiving ciclosporin with or without other immunosuppressive agents, administration of Hypravas 20 with an initial dose of 20 mg once daily and titration to 40 mg should be done with caution. important. Combination with protease inhibitors: There is no dose limitation of Hypravas 20 when combined with the following HIV and HCV protease inhibitors: Atazanavir Atazanavir + Ritonavir Darunavir + Ritonavir Lopinavir + Ritonavir There have been reports of a some cases of pravastatin overdose. There were no cases with special symptoms and all recovered without leaving any sequelae. If you overdose on Hypravas 20, you should receive symptomatic treatment and support when necessary.
3. Side effects of Hypravas 20
Hypravas 20 is well tolerated, with a lower discontinuation rate compared to other lipid-lowering agents.
Less common side effects of Hypravas 20 include:
Dizziness Headache Sleep disturbance, insomnia. Visual disturbances such as double vision, blurred vision. Indigestion, flatulence. Heartburn Abdominal pain Nausea, vomiting Constipation Diarrhea. Itching, skin rash Urticaria Hair loss Abnormal urination such as difficulty urinating, nocturia. Sexual dysfunction. Joint pain Muscle spasticity Myalgia Muscle weakness Increased plasma creatine kinase (CK) levels. Increased serum transaminases. Very rare side effects of Hypravas 20 include:
Peripheral polyneuritis Paresthesia. Hypersensitivity reactions such as anaphylaxis, lupus-like syndrome, angioedema. Pancreatitis Jaundice Hepatitis, hepatocellular necrosis. Paroxysmal myoglobinuria leads to acute renal failure, myositis, and polymyositis.
4. Drug interactions Hypravas 20 with other drugs
The combination of Hypravas 20 and fibrates (eg, gemfibrozil, fenofibrate) should be avoided due to increased muscle toxicity. If co-administration is necessary, clinical and creatinine kinase monitoring should be cautious in the patient. Using Hypravas 20 with Colestyramine/Colestipol reduces the bioavailability of pravastatin by approximately 40-50% when co-administered. Hypravas 20 should be taken 1 hour or 4 hours after colestyramine or 1 hour before colestipol. When using Ciclosporin with Hypravas 20 can increase the amount of pravastatin in the body by 4 times. Patients need to be controlled clinically and biochemical indicators when using these 2 drugs in combination. When Hypravas 20 is used together with erythromycin or clarithromycin, there is an increase in the AUC and Cmax of pravastatin. When using Hypravas 20 with Colchicine, there is an increased risk of myopathy/rhabdomyolysis. When Hypravas 20 is used together with Niacin, there may be an increased risk of effects on skeletal muscle. In this case, you should consider reducing the dose of Hypravas 20. The above is important information about Hypravas 20, knowing how to use the drug and store it will help the treatment become more effective and safer. for patients.
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