Uses of Atovze 20/10

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1. What is Atovze?

What is Atovze? Atovze drug 20/10 is a lipid-lowering drug, prepared in the form of film-coated tablets, with the main ingredients being:
Atorvastatin (in the form of Atorvastatin calcium trihydrate) 20mg Ezetimibe 10mg Cholesterol in the blood has two origins: One part has Exogenous origin is absorbed from the intestine and a part of endogenous origin is synthesized by the body. Atovze is a combination of two active ingredients, ezetimibe and atorvastatin, which reduces plasma cholesterol by inhibiting both absorption and synthesis. Ezetimibe has been shown to reduce plasma cholesterol by inhibiting the absorption of cholesterol in the small intestine. Atorvastatin is a synthetic lipid-lowering agent that is an inhibitor of the reductase 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting stage of cholesterol biosynthesis. Atorvastatin is effective in lowering total cholesterol, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B). Atorvastatin is also effective in lowering very low-molecular-weight lipoprotein cholesterol (VLDL-C) and triglycerides (TG), while increasing high-density lipoprotein cholesterol (HDL-C).
Atovze 20/10 is indicated in the following cases:
Hypercholesterolemia. Coronary artery disease associated with hypercholesterolemia, Atovze is indicated to reduce the risk of coronary death, reduce the risk of non-fatal myocardial infarction, and reduce the risk of myocardial revascularization. heart, while slowing down the process of coronary atherosclerosis, reducing the formation of new lesions. Atovze 20/10 is contraindicated in the following cases:
People who are sensitive to any of the ingredients of the drug. People with liver disease or persistent elevation of transaminases of unknown cause. Pregnant and lactating women.

2. Dosage and how to use Atovze 20/10

You should follow a low cholesterol diet when you start using Atovze and continue following this diet for the duration of treatment.
Dosage of Atovze should be individually adjusted based on the level of cholesterol in the blood. Dosage of Atovze drug should be according to the doctor's prescription, the recommended dose for the following cases:
Dosage of Atovze is calculated according to the dose of Atorvastatin: Use a dose of 10mg, once a day. The maximum dose is 80mg/day. The usual dose of Atovze is 1 - 4 tablets (Atorvastatin 20mg, Ezetimibe 10mg)/day. The starting dose should be 1 tablet Atovze 20/10/day. After 2 weeks, it is necessary to re-check the plasma cholesterol concentration. If necessary, the dose of Atovze can be adjusted. Patients taking cyclosporin can only take Atovze if the patient can tolerate atorvastatin doses of 5 mg or more, but should not take more than 1/2 tablet per day. Patients taking amiodarone or verapamil should not take Atovze 20/10 more than 1 tablet per day.

3. Atovze 20/10 side effects

In general, Atovze is well tolerated, with a lower discontinuation rate compared with other lipid-lowering agents. Common side effects of Atovze 20/10 include: Diarrhea, constipation, flatulence, abdominal pain and nausea. Headache . Blurred vision Insomnia, weakness. Muscle pain, joint pain. Liver function tests increased to more than 3 times the upper limit of normal, but most patients were asymptomatic and recovered on discontinuation of the drug. Uncommon side effects of Atovze 20/10 include:
Myopathy combined with muscle weakness and increased plasma creatine phosphokinase (CPK)). Skin board. Pharyngitis, rhinitis, sinusitis, cough. Rare side effects of Atovze 20/10 include:
Myositis, rhabdomyolysis, the body leads to acute kidney failure secondary to myoglobinuria. If you experience any side effects of Atovze, you need to immediately inform your doctor, or immediately go to the nearest medical facility for timely treatment.

4. Interaction of Atovze 20/10 with other drugs

Concomitant administration of Atovze with CYP3A4 inhibitors may increase blood levels of atorvastatin leading to an increased risk of myopathy and myopathy. When taking Atovze with amiodarone, a dose of 20 mg of atorvastatin/day should not be exceeded. Increasing the dose increases the risk of rhabdomyolysis. For patients who must take Atovze at doses above 20 mg/day to be effective, doctors may choose another statin drug such as pravastatin. Atovze slightly increases the anticoagulant effect of coumarin. In patients receiving coumarin anticoagulants, prothrombin time should be checked before and during atorvastatin therapy. Caution should be exercised when Atovze is co-administered with niacin or other immunosuppressive agents. The risk of myopathy during treatment with Atovze is increased with concomitant use of cyclosporin, fibric acid derivatives, azole antifungals or niacin, and erythromycin. Concomitant administration of Atovze with antacid suspensions containing magnesium and aluminum hydroxide resulted in a decrease in plasma concentrations of atorvastatin by approximately 35%. However, the effect of lowering low molecular weight cholesterol index did not change. When colestipol was co-administered with Atovze, atorvastatin concentrations were reduced by approximately 25%. When multiple doses of digoxin were administered concomitantly with Atovze at a daily dose of 80 mg of atorvastatin, digoxin concentrations increased by approximately 20%. Therefore, appropriate monitoring is required in patients receiving digoxin. Concomitant administration of Atovze and erythromycin (500 mg 4 times/day) or clarithromycin (500 mg twice daily) increases plasma concentrations of atorvastatin. Concomitant administration of Atovze and protease inhibitors that are cytochrome P450 3A4 inhibitors will increase plasma concentrations of atorvastatin. Atovze drug 20/10 is a drug used in the treatment of a number of diseases such as hyperlipidemia, coronary artery disease. To ensure effective treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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