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Hypolip medicine 20mg has the main ingredient is Atorvastatin and other excipients in a sufficient amount. The drug belongs to the group of cardiovascular drugs and is indicated for the reduction of total cholesterol, LDL-cholesterol, apolipoprotein B and triglycerides. At the same time, the drug also works to increase HDL-cholesterol in people with primary hypercholesterolemia very effectively.
1. What is Hypolip? The effect of the drug Hypolip
1.1. Pharmacodynamics of Hypolip Active ingredient Atorvastatin is a drug belonging to the group of drugs known as HMG-CoA reductase inhibitors.
1.2. Pharmacokinetics of the drug Hypolip Absorption: Active ingredient Atorvastatin is rapidly absorbed from the gastrointestinal tract, absorption of the drug is not affected by food. The bioavailability of Atorvastatin is low because of its extensive first-pass metabolism (more than 60%). The concentration of the drug peaks in the serum after 1 to 2 hours. Distribution: Atorvastatin is strongly bound to plasma proteins over 98%. Because Atorvastatin is lipophilic, it crosses the blood-brain barrier. Metabolism: Hypolip is converted mainly in the liver with more than 70% to active or inactive metabolites. Elimination ability: Hypolip 20mg drug is excreted mainly in the feces, less than 2% excreted by the kidneys. 1.3. The effect of the drug Hypolip 20mg Pharmaceutical substance Atorvastatin is a cholesterol-lowering drug. The drug works by inhibiting the production of cholesterol in the liver by inhibiting a cholesterol-producing enzyme, HMGCoA reductase. Hypolip 20mg drug works:
Reduces the total cholesterol index as well as the LDL cholesterol in the blood (LDL cholesterol is considered the "bad" cholesterol that plays a major role in coronary heart disease). Lowering LDL cholesterol levels slows the progression and may even reverse coronary heart disease. Decreased blood triglyceride levels: Elevated blood triglyceride levels are also associated with coronary heart disease.
2. Indications of the drug Hypolip
Hypolip is indicated for use in the following cases:
Atorvastatin is indicated to reduce levels of Total Cholesterol, LDL-cholesterol and apolipoprotein B and triglycerides and to increase HDL-cholesterol in people with primary hypercholesterolemia. People with beta-lipoproteinemia who do not respond adequately to daily nutrition. Atorvastatin is also indicated for the reduction of total cholesterol and LDL-cholesterol in individuals with homozygous familial hypercholesterolemia.
3. How to use and dose of Hypolip
How to use Hypolip: Hypolip is used orally.
Therapeutic dose of Hypolip:
Hypercholesterolemia (heterozygous familial and non-familial) and mixed dyslipidemia: the recommended starting dose is 10-20mg, 1 times/day. Those who need a significant reduction in LDL cholesterol (more than 45%) can start with a therapeutic dose of 40mg once daily. The therapeutic dose range of Hypolip is 10-80mg once daily. After initiation of treatment and/or after increasing the dose of Atorvastatin active ingredient, lipid levels should be assessed within 2 to 4 weeks and the therapeutic dose adjusted accordingly. Homozygous familial hypercholesterolemia: oral therapeutic dose of 10-80mg/day. Doctors often prescribe in combination with other lipid-lowering measures. Combination therapy: Atorvastatin can be used in combination with Resin to increase the effectiveness of treatment. Therapeutic dose for people with renal failure: no need to adjust the therapeutic dose.
4. Undesirable effects of the drug Hypolip
Common undesirable effects:
Nasopharyngitis; Allergic reaction ; Increased blood sugar; Headache; Digestive disorders such as constipation, flatulence, indigestion, nausea and vomiting; Muscle pain, pain in joints, back pain, pain in limbs, muscle spasms, joint swelling...; The liver function test indicators are abnormal, the concentration in the blood is increased. Uncommon side effects:
Hypoglycemia, weight gain, loss of appetite; Psychiatric disorders: frequent nightmares, insomnia; Dizziness, loss of sensation, drowsiness; Decreased eyesight; Tinnitus ; Hepatitis; hives, rash, itching on the skin; Neck pain, muscle fatigue; White blood cells positive. Undesirable effects rarely occur:
Thrombocytopenia; Peripheral neuropathy; Visual disturbances; Cholestasis; Myalgia, myositis, rhabdomyolysis, osteoarthritis. Very rare side effects:
Hearing loss; Liver failure... You need to pay attention to inform your doctor about the unwanted effects encountered when using Hypolip.
5. Drug interactions Hypolip
Anticoagulants, Indandione in combination with Atorvastatin will increase bleeding time or prothrombin time. Patients should pay attention to monitor prothrombin time in those receiving combination therapy with anticoagulants.
Cyclosporine, Erythromycin, Gemfibrozil, immunosuppressants, niacin: combined use increases the risk of myopathy.
Digoxin: Co-administration with Hypolip causes a slight increase in serum digoxin concentrations.
6. Some notes when using Hypolip
6.1. Contraindications of the drug Hypolip 20mg Hypersensitivity or hypersensitivity to any component of the drug. Women who are pregnant or breastfeeding. Patients with liver disease or persistent elevations of serum transaminases of unknown etiology. 6.2. Notes and cautions when using Hypolip-20 It is necessary to use lipid-lowering drugs in conjunction with a low-saturated fat, low cholesterol diet and only when there is no adequate response to the diet and to other drugs. non-drug measures. Before treatment with Hypolip, it is necessary to rule out secondary causes of elevated cholesterol (eg, uncontrolled diabetes, impaired thyroid function, nephrotic syndrome, dysproteinemia, obstructive liver disease, alcoholism) ,...) and need to carefully check blood lipids. It is necessary to do liver function test before treatment with Hypolip, during the use of the drug, it is necessary to monitor liver function regularly. Use caution when using Hypolip for people who are addicted to alcohol, or drink a lot of alcohol with a history of liver disease. Users should be warned about the risk of muscle problems such as muscle pain, muscle tension or unexplained weakness. Increased risk of muscle damage when statins are used concurrently with: Gemfibrozil, other fibrate-lowering agents, high-dose niacin (> 1g/day), colchicine. Concomitant use of statins with lipid-lowering agents for HIV and hepatitis C may increase the risk of muscle damage. Most seriously, causing rhabdomyolysis, kidney failure leads to kidney failure and can be life-threatening. In addition, it should be noted that Hypolip should not be used by pregnant and lactating women. If you have any questions, please contact your treating doctor or clinical pharmacist for the most accurate answer.
Use of Hypolip in driving and operating machinery: Use caution when using Hypolip for drivers and operators.
Hypolip medicine 20mg has the main ingredient is Atorvastatin and other excipients in a sufficient amount. The drug belongs to the group of cardiovascular drugs and is indicated for the reduction of total cholesterol, LDL-cholesterol, apolipoprotein B and triglycerides. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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