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Glumeform 500 is an oral antidiabetic drug. The drug is indicated for use in cases of non-insulin dependent diabetes mellitus. To use Glumeform 500 most effectively and safely, you need to learn information about the drug through the article below.
1. Uses of Glumeform 500
The composition of the drug Glumeform is Metformin 500mg and excipients just enough. The drug is in the form of film-coated tablets. Glumeform is an antidiabetic drug with the active ingredient Metformin, belonging to the Biguanide group. Metformin reduces fasting and postprandial plasma glucose concentrations in patients with type 2 diabetes. Metformin's mechanism of action is by inhibiting the synthesis of glucose from lactic acid in the liver and reducing intestinal glucose absorption, increasing glucose utilization in cells, and improving insulin sensitivity to receptors on the cell surface. cells, stimulating the anaerobic breakdown of glucose. The drug also causes a side effect of loss of appetite, causing patients to reduce their consumption of foods high in carbohydrates.
Glumeform reduces hyperglycemia in people with diabetes but does not usually cause hypoglycaemic events, except in cases of fasting or in combination with other contractile agents with a risk of hypoglycaemia. .
In addition to the anti-hyperglycemic effect, when taking Glumeform, it also has a beneficial effect on blood lipid components in patients with type 2 diabetes. The drug works to reduce triglyceride, total cholesterol and LDL levels. cholesterol. Increased fibrinolytic activity and decreased platelet aggregation have also been reported in diabetic patients following treatment with Metformin, which reduces the risk of thrombosis.
When used orally Metformin is slowly and incompletely absorbed from the gastrointestinal tract. Bioavailability after oral administration is about 50-60%. When taken together, food reduces the extent and rate of absorption of Metformin.
2. Indications and contraindications of Glumeform 500
Glumeform 500 is indicated for use in the following cases:
Treatment of type 2 diabetes (non-insulin dependent). It is often chosen to treat type 2 diabetes when the patient is overweight-obese, after applying a diet but it has not been effective. Glumeform 500 is contraindicated in the following cases:
History of hypersensitivity to the components of the drug. The patient has an acute catabolic state, infection, trauma. Acute or chronic metabolic acidosis. Patients with renal failure or severe liver disease, cardiovascular disease, respiratory disease have hypoxemia. Congestive heart failure, cardiovascular collapse and acute myocardial infarction. Severe infections. Gangrene, alcoholism, malnutrition. Pregnant and lactating women. Metformin must be temporarily discontinued for patients undergoing radiographic examination using iodinated contrast agents because of the potential for acute severe effects on renal function.
3. Dosage and how to use Glumeform 500
How to use: The drug is taken orally. The medicine should be taken with food. When taking, it is necessary to swallow the tablet, take it during or at the end of a meal.
Dosage: Dosage will be based on effectiveness and tolerance of the patient but should not exceed 5 tablets/day.
Starting dose: Take 1 tablet and take it 2 times a day, taken with meals. When necessary, if blood sugar is not well controlled, the dose can be increased to 1 tablet x 3 times/day. Maintenance dose: Take 1 tablet x 2-3 times/day, take with meals. Overdose: No acute decrease in blood glucose has been observed after a dose of 85g Metformin, although high doses may cause lactic acidosis. An overdose should be treated in a hospital, treatment consisting of supportive and symptomatic treatment. Hemodialysis may be necessary to remove accumulated drug in patients with suspected drug overdose.
4. Side effects of the drug Glumeform 500
When using Glumeform 500 you may also experience unwanted effects, including:
Common side effects: Digestive disorders (loss of appetite, nausea and vomiting, diarrhea, feeling of fullness in the stomach). , constipation, heartburn); rash, urticaria; decreased blood levels of vitamin B12. Uncommon side effects: Blood dysplasia, aplastic anemia, hemolytic anemia, myelosuppression, thrombocytopenia, risk of bleeding due to thrombocytopenia, agranulocytosis, lactic acidosis. When experiencing side effects of the drug, you need to stop using it and immediately notify your doctor or go to the nearest medical facility for timely treatment.
5. Note when using Glumeform 500
Before using the drug, you need to inform your doctor about your history of allergies and medical conditions.
The risk of drug accumulation and lactic acidosis increases with the degree of decline in renal function.
Metformin must be stopped during surgery.
Caution should be taken when using Metformin in combination with other antidiabetic agents because of the risk of hypoglycemia causing dizziness, weakness or fainting. This affects the ability to operate the machine.
Lactation period: Should carefully consider stopping breastfeeding or stopping the drug, based on the importance of Metformin drug to the mother.
When taking medicine, you still need to make sure to adhere to a controlled carbohydrate diet, exercise to improve health. This increases the effectiveness of treatment and reduces the amount of medication that must be used, reducing the risk of complications.
Drug interactions: Some drugs that can cause interactions with Glumeform 500 include:
Diuretics, Corticosteroids, Phenothiazines, birth control pills, Oestrogens, Phenytoin, nicotinic acid, calcium channel blockers, Isoniazid, Sympathomimetic agents reduce the glycemic control effect of Metformin. Drugs that are eliminated by the kidneys (Amiloride, Digoxin, Morphin, Ranitidine, Trimethoprim, Vancomycin ...) interact with Metformin by competing for renal tubular elimination, reducing elimination causing drug accumulation. Cimetidine has the effect of increasing the peak plasma concentration of Metformin by 60%, therefore, concomitant use with cimetidine should be avoided. Storage: Keep the medicine in a cool place, away from light, at a temperature below 300C. Keep out of reach of children and pets.
Glumeform 500 is a prescription drug, used under the direction of a doctor, you do not arbitrarily use to avoid the risk of harm to the body. Consult your doctor before taking the medicine to make sure it is safe.
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