Kombiglyze XR: Uses, indications and precautions when using

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Type 2 diabetes is a common disease today. The disease will get worse over time, causing patients to need a combination of drugs to treat it instead of a monotherapy with metformin. A good example of a combination diabetes drug is Kombiglyze XR. So what does Kombiglyze do?

1. What does Kombiglyze do?

Kombiglyze XR is a combination product of Saxagliptin and Metformin. So what does Kombiglyze do? Kombiglyze XR is used together with a moderate diet and an appropriate exercise program to control blood sugar in patients with type 2 diabetes.
Stable blood sugar control helps prevent diabetes complications on the kidneys, eyes, peripheral nerves and blood vessels and problems with sexual function. Controlling type 2 diabetes can reduce coronary events or strokes.
Saxagliptin works to increase the effectiveness of incretin (a hormone of the body), thereby helping to control blood sugar by increasing the effectiveness of insulin (especially after meals). In addition, this active ingredient also helps to reduce the liver's new glucose production. Metformin lowers blood sugar by helping the body to increase insulin sensitivity, while reducing glucose production in the liver and reducing sugar absorption in the intestine.

2. How to use Kombiglyze XR

Patients should read the medication instructions provided by the pharmacist before you start using Kombiglyze XR. Kombiglyze XR is to be taken by mouth as directed by your doctor, usually once a day with the evening meal.
Do not crush or chew Kombiglyze XR delayed release tablets to avoid releasing all active ingredients at once and increasing the risk of side effects. In addition, do not split treatment tablets unless they have a dividing line or are ordered by your doctor or pharmacist. Also, drink plenty of fluids while taking Kombiglyze XR unless otherwise directed by your doctor. The dose of Kombiglyze XR is prescribed based on the patient's medical condition, degree of diabetes, response to treatment and other drugs the patient is taking. To reduce the risk of Kombiglyze XR side effects (such as abdominal pain), your doctor may prescribe a low dose and gradually increase the dose according to the patient's response.
Patients should use Kombiglyze XR regularly and regularly to achieve the best effect. Patients with diabetes need to carefully follow their doctor's treatment plan with medications, diet, and exercise program.

3. Side effects of the drug Kombiglyze XR

Common side effects of Kombiglyze XR include:
Nausea, vomiting; Stomach upset; Diarrhea ; Headache; There is a metallic taste in the mouth. If the effects of Kombiglyze XR persist or worsen, tell your doctor or pharmacist right away. If stomach symptoms return (after taking the same dose for several days or weeks), notify your doctor promptly as these may be signs of acidosis. blood lactic acid.
Empty pill shells may appear in the user's stool. This effect is harmless because the body has already absorbed the active ingredients in the medicine.
Some serious side effects of Kombiglyze XR should contact your doctor, including:
Joint pain; Unusual blistering of the skin; Signs of heart failure (such as shortness of breath, leg swelling, unusual tiredness, unusual/sudden weight gain). Although Kombiglyze XR does not usually cause excessive hypoglycemia, this effect can occur when patients use it in combination with other antidiabetic drugs.
Symptoms of hypoglycemia include sweating, shaking, fast heartbeat, feeling of hunger, blurred vision, dizziness or tingling in the hands/feet. Hypoglycemia is more likely to occur if the patient drinks a lot of alcohol, is physically active, or is not eating enough calories. To help prevent this, eat well on schedule and don't skip meals. Symptoms of hyperglycemia include increased thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath. If these symptoms occur, the person with diabetes should notify their doctor promptly and the dose of medication may need to be adjusted.
Get medical help right away if you have very serious side effects of Kombiglyze XR such as: Signs of pancreatic disease (such as severe stomach/abdominal pain that spreads to the back, nausea, vomiting not cease).

4. Notes when using the drug Kombiglyze XR

Before prescribing Kombiglyze XR for diabetes, your doctor or pharmacist should ask you for a history of allergy to saxagliptin or metformin and any other allergies.
Before using Kombiglyze XR, please tell your doctor or pharmacist your medical history, especially:
Kidney disease; Severe breathing problems (such as chronic obstructive pulmonary disease, severe asthma); Blood problems (anemia, B12 deficiency); Liver disease; Disease of the pancreas (pancreatitis) or risk factors for pancreatitis (eg, gallstones, alcohol use/abuse, hypertriglyceridemia). Before surgery or any imaging procedure that requires the use of iodinated contrast media, a patient should tell their doctor about all medications they are taking. Patients may need to stop taking Kombiglyze XR for a short time to undergo surgery/procedure.
Patients using Kombiglyze XR may experience blurred vision, dizziness or drowsiness due to excessively low or high blood sugar. Do not drive, use machinery, or perform any activity that requires alertness or clear vision until the sick person is sure it can be done safely. Limit alcohol while taking Kombiglyze XR because alcohol increases the risk of lactic acidosis, pancreatitis, and hypoglycemia.
High fever, use of diuretics (such as hydrochlorothiazide), excessive sweating, diarrhea or vomiting can cause severe dehydration and increase the risk of lactic acidosis. Stop Kombiglyze XR and tell your doctor right away if you have persistent diarrhea or vomiting. At the same time, the person needs to make sure to drink enough fluids to prevent dehydration unless directed otherwise by the doctor.
It can be difficult to control blood sugar when the body is under physical stress (such as due to fever, infection, injury or surgery). Consult your doctor as this may require changes to your treatment plan, medications, or blood sugar testing.
Older adults may be more sensitive to the side effects of Kombiglyze XR, especially hypoglycemia or lactic acidosis.
Metformin can cause changes in your menstrual cycle (promote ovulation) and increase your chances of getting pregnant. Consult your doctor or pharmacist for reliable birth control methods while taking Kombiglyze XR. During pregnancy, Kombiglyze XR should be used only when clearly needed, and the patient should discuss the risks and benefits with their doctor prior to use. Pregnancy can cause or worsen diabetes. Your doctor may change your treatment for a condition during pregnancy (such as diet and insulin therapy). Metformin passes into breast milk in small amounts and it is not known whether saxagliptin passes into breast milk, so consult your doctor before breast-feeding.

5. Drug interactions of Kombiglyze XR

Drug interactions can change the way Kombiglyze XR works or increase your risk of serious side effects. Make a list of all the products you are using (including prescription, non-prescription and herbal products) and share them with your doctor and pharmacist. Also, do not start, stop, or change the dose of any medication without your doctor's approval during treatment with Kombiglyze XR.
Beta-blockers (such as metoprolol, propranolol, glaucoma eye drops such as timolol) can prevent tachycardia - a symptom that patients often feel when hypoglycemia is low (masking hypoglycemia). ). Other symptoms of hypoglycemia such as dizziness, hunger, sweating... are not affected by these drugs.
Overdosage of Kombiglyze XR can cause lactic acidosis. Overdose symptoms may include: severe drowsiness, nausea, vomiting, diarrhea, rapid breathing, slow heartbeat, irregular heartbeat.
Patients need to learn the symptoms of hypoglycemia and how to treat low blood sugar, and check blood sugar regularly as directed.
Tests such as kidney function, liver function, blood sugar, hemoglobin A1c, complete blood count... should be done before the patient starts taking Kombiglyze XR and while taking it.
If patient misses a dose of Kombiglyze XR, take it as soon as you remember, if it is almost time for the next dose, skip the missed dose, do not double the dose.
Store Kombiglyze XR at room temperature, away from light and moisture, away from children and pets. Do not flush Kombiglyze XR down the toilet or down the drain, dispose of this product appropriately when it has expired or is no longer needed.
Kombiglyze XR is used together with a moderate diet and an appropriate exercise program to control blood sugar in patients with type 2 diabetes. To ensure effective treatment, patients need to take the drug as prescribed. or as directed by a doctor or pharmacist.

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Reference source: webmd.com