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Glihexal drug containing the active ingredient Glibenclamide is used for subjects with diabetes. So how to use the drug properly?
1. What does Glihexal do?
Glihexal medicine contains the active ingredient Glibenclamide. This is a sulfonylurea drug that is effective in the treatment of diabetes thanks to its ability to reduce blood glucose levels, by increasing the sensitivity of pancreatic beta cells to glucose, thus increasing insulin release. The secretory function of beta cells determines the drug-dependent effect. In addition, Glibenclamide increases insulin levels by reducing the clearance of insulin by the liver.The mechanism of action of glibenclamide is to increase the release of pancreatic insulin when first administered to non-insulin dependent diabetics. Initially when used, sulfonylureas increase insulin response, after a while, blood insulin concentration is adjusted to a stable level but plasma glucose concentration remains low.
2. Indications of the drug Glihexal
Glihexal is indicated for the treatment of non-insulin dependent diabetes mellitus (type 2 diabetes mellitus) in cases where the patient's blood sugar cannot be controlled by diet or exercise alone.3. How to use Glihexal
The appointment and dosage adjustment of Glihexal drug depends on the results of the patient's blood sugar test. Experts recommend starting at a low dose with half a 1.75mg Glibenclamide tablet, then gradually increasing the dose until optimal glycemic control is achieved after several days of treatment.
Dosage ranges from half a Glihexal 1.75mg tablet to 3 3.5mg tablets, divided into 2 doses at the beginning of a meal. When using a daily dose of 3 tablets, the dose will be distributed in the ratio of 2 parts in the early morning and 1 part in the afternoon before meals. Patients need to strictly adhere to the diet while taking the drug as prescribed by the doctor.
4. Contraindications to the use of Glihexal
Glihexal drug is contraindicated for use in some cases such as:
Patients with a history of hypersensitivity to any component of the drug Glihexal. Patients with type 1 diabetes (insulin dependent). Patients with hyperglycemia are in a diabetic coma or pre-coma. People who have undergone pancreatectomy. The patient had severe diabetic acidosis. People with severe liver and kidney failure.
5. Side effects of the drug Glihexal
Glihexal with the active ingredient glibenclamide in the form of microparticles is generally well tolerated. Therefore, side effects such as gastrointestinal disturbances or allergic reactions especially in the skin are very rare and also very rarely affecting the blood.
In summary, Glihexal drug containing the active ingredient Glibenclamide is used for subjects with diabetes. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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