This is an automatically translated article.
Gemfibstad 300 is a drug with hypolipidemic effects, especially applied in cases of increased triglycerides to help reduce the risk of pancreatitis caused by this condition. So how should Gemfibstad 300 be used?1. What is Gemfibstad 300?
Gemfibstad 300 drug has the main ingredient is Gemfibrozil 300mg, made in hard capsule form.Gemfibrozil is a fibric acid analog and belongs to the class of anti-hyperlipidemic drugs. Gemfibrozil has been shown to reduce triglyceride-rich lipoprotein levels, decrease VLDL (very low density lipoprotein), slightly increase HDL levels, and have different effects on LDL. The effect on VLDL concentrations is mainly due to increased lipoprotein lipase activity, especially in muscle, leading to increased hydrolysis of VLDL triglycerides and increased VLDL catabolism.
Gemfibrozil also reduces triglyceride synthesis in VLDL in the liver. In addition to the effect on blood lipids, gemfibrozil also works to reduce platelet aggregation, reducing the risk of cardiovascular disease. Clinical application has shown that gemfibrozil in people with homozygous hyperlipidemia apoE2/apoE2 have the best response to gemfibrozil therapy. Triglyceride and cholesterol levels can be drastically reduced, the effect on vitiligo can be completely reduced.
2. Uses of the drug Gemfibstad 300
Indications:Gemfibstad 300mg is indicated for use in the following cases:
The drug of choice for the treatment of homozygous apoE2/apoE2 hyperlipidemia (hyperlipoproteinemia - type III). Moderate to severe hypertriglyceridemia increases the risk of pancreatitis. Familial combined hyperlipidemia, increased VLDL concentration. If LDL levels are high, additional low-dose HMG CoA reductase inhibitors are often indicated. The drug is also indicated for the treatment of hyperlipidemia and to help reduce the risk of coronary heart disease in patients with type llb hyperlipidemia but without a history or current symptoms of coronary artery disease.. Indications for treatment of hyperlipidemia Severe primary bleeding with coronary artery disease risk, abdominal pain typical of pancreatitis, unresponsive to diet or other measures alone. Contraindications:
Do not use Gemfibstad 300 in the following cases:
Patients with hypersensitivity to gemfibrozil or any of its ingredients (Excipients include Microcrystallin cellulose, sodium starch glycolate, hydroxypropyl cellulose, polysorbate). 80, colloidal anhydrous silica, magnesium stearate Tacl). Renal dysfunction, gallbladder disease, primary biliary cirrhosis. Gemfibrozil should not be used by pregnant women and children.
3. Dosage of the drug Gemfibstad 300
How to use:The drug is taken orally, about 30 minutes before breakfast and dinner.
Dosage:
The usual dose for adults is 600 mg (2 tablets) / time and used 2 times a day. Note: The drug must be discontinued after 3 months if there is no significant change in serum lipoprotein levels. Missed dose and overdose:
Overdose: An overdose of the drug can cause overdose symptoms including abdominal pain, diarrhea, nausea, vomiting. The management of gemfibrozil overdose consists of symptomatic and supportive treatment. In case of symptoms of acute gemfibrozil overdose, gastric emptying should be done immediately by induction of vomiting or gastric lavage. Missed dose: If you forget to take a dose, take it again as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
4. Side effects when using Gemfibstad 300
When using Gemfibstad 300, you can sometimes experience unwanted effects, although Gemfibrozil side effects are usually quite uncommon and mild. However, in some cases, the side effects of the drug in the gastrointestinal tract can be quite severe to the point of stopping the drug. Side effects include:Common side effects:
Gastrointestinal: Indigestion, abdominal pain , diarrhea or constipation, nausea and vomiting, acute appendicitis. Gallstones. Central nervous system: Fatigue, dizziness, headache. Skin: Rash, dermatitis. When using the drug, if you notice any side effects, you should notify your doctor for advice and timely handling.
5. Many things to note when using Gemfibstad 300
Before using the drug, it is necessary to inform the doctor about the medical history and allergy history.Do biochemical tests to accurately diagnose hyperlipidemia. Before starting treatment with the drug, you should control your blood fat with an appropriate diet, exercise, lose weight if you are overweight or obese, and need to control other diseases such as diabetes and hypothyroidism that are contributing. responsible for lipid abnormalities. If it's not okay, it needs to be treated with medicine.
During treatment with Gemfibstad 300 you need:
Periodically test serum lipids to evaluate the effect of the drug, stop the drug if the effect is poor after 3 months of treatment. Have an appropriate serum lipid-lowering diet and exercise. Machine operators: Because the drug can cause dizziness and drowsiness, it is necessary to pay attention to this operation, especially during the first time taking the drug. Pregnancy: Because the drug crosses the placenta, it has not been adequately studied. Therefore, gemfibrozil should not be used during pregnancy. Lactation: It is not known whether gemfibrozil is distributed into breast milk. Because of the potential for serious side effects in a nursing infant, breast-feeding should be avoided or administered to a nursing woman. Drug Interactions:
Coumarin or indandion-derivative anticoagulants: Concomitant use of anticoagulants with Gemfibrozil may significantly increase the anticoagulant effect of these drugs; Therefore, it is necessary to adjust the anticoagulant dose based on the prothrombin time test. Lovastatin: The statin class of lipid-lowering drugs, if used concurrently with gemfibrozil, may increase the risk of rhabdomyolysis; increased levels of creatine kinase, myoglobinuria can lead to acute renal failure; This condition can be detected 3 weeks and as late as 1 month after starting combination therapy. Gemfibstad 300 is a prescription drug for the treatment of hyperlipidemia, which can be used as monotherapy or in combination to help reduce blood lipids thereby reducing the risk of complications. You need to consult your doctor before use to ensure safety.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
