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Galaxda drug is made in the form of hard capsules, with the main ingredient being Diacerein. The drug is used in the treatment of degenerative joint diseases.
1. What does Galaxda 25 do?
In each Galaxda 25 tablet contains the main ingredient Diacerein 25mg and other excipients. Diacerein is a new anti-osteoarthritis drug used to treat degenerative joint diseases such as osteoarthritis and other related diseases. The drug is well tolerated in the stomach, because it does not inhibit prostaglandin synthesis. Diacerein is the only drug among anti-arthritic drugs available today that has the ability to affect the anabolism, catabolism of chondrocytes and mitigate proinflammatory factors. The results of several studies suggest that Diacerein and Rhein (an active metabolite of it) inhibit the production and activity of the proinflammatory and pro-catabolic cytokine IL-1b, both in superficial and deep layers of cartilage, in the synovial membrane and synovial fluid, and stimulates the production of transforming growth factor (TGF-b) and components of extracellular substances such as aggrecan, hyaluronic acid , proteoglycans and type II colloids. Besides, these substances also inhibit the phagocytosis and migration of macrophages. Studies in several animal models of osteoarthritis have also shown that Diacerein reduces cartilage degeneration compared with untreated groups.
Indications : For specific long-term oral treatment of degenerative joint diseases (osteoarthritis, some related diseases). Contraindications: Diacerein should not be used in patients with known hypersensitivity to any of the components of the drug or who have a history of hypersensitivity to anthraquinone derivatives. Careful consideration should be given to weighing the benefits versus risks of using Diacerein in patients with pre-existing intestinal disorders, particularly those with irritable colon.
2. How to use and dose Galaxda 25
Usage: Orally.
Dosage: Since Diacerein can rapidly increase the time it takes for food to pass through the intestines during the first 2 weeks of treatment, treatment should be started with 2 tablets per day, taken with the evening meal for 2 weeks. When the patient is used to this drug, the dose can be increased to 4 capsules per day. The doctor should pay attention to deciding the duration of treatment to be effective.
In addition, because Diacerein has a slow onset of effect, usually observed after about 2-4 weeks of treatment, it is advisable that patients should not discontinue treatment before the effect of the drug is evident. The drug is well tolerated by the gastrointestinal tract and does not inhibit prostaglandin synthesis, so it is not harmful to the stomach, but because of its slow onset of action, it can be used in combination with a non-steroidal anti-inflammatory drug (NSAID). NSAID) or pain reliever for the first 2-4 weeks of treatment.
Overdose: Using high doses of Diacerein by mistake or intentional can cause diarrhea. Treatment is symptomatic treatment. If diarrhea persists, the patient should contact the doctor for specific instructions. In addition, in case of necessity, the patient is also given emergency treatment including restoring water-electrolyte balance.
3. Side effects of the drug Galaxda 25
When using the drug Galaxda 25, patients may experience some unwanted effects such as:
The time for food to pass through the intestines increases, abdominal pain, diarrhea are the most common. These undesirable symptoms may appear within the first few days of treatment and most of them resolve on their own with continued treatment; Taking Galaxda 25 can sometimes make the urine darker yellow. However, this finding is of no clinical significance. If you experience any adverse side effects while taking Galaxda 25, you should immediately inform your doctor and get advice on the appropriate management.
4. Be careful when using Galaxda 25
Some notes for patients to remember before and during Galaxda 25:
Renal failure may alter the pharmacokinetics of Diacerein. Therefore, the dose should be reduced in patients with renal impairment (creatinine clearance < 30 ml/min); The drug should not be used concurrently with laxatives with Galaxda 25 ; Galaxda 25 should not be prescribed to children under the age of 15 because there are no clinical studies in this age group. Galaxda 25 should not be used during pregnancy; Galaxda 25 should not be prescribed to women who are breastfeeding because it has been reported that small amounts of Diacerein derivatives pass into breast milk; Galaxda 25 does not affect the ability to drive and use machines, so users can rest assured to do these jobs.
5. Galaxda drug interactions 25
Some drug interactions of Galaxda 25 include: Concomitant use of Galaxda 25 with drugs containing salts, oxides or hydroxides of aluminum, magnesium and calcium should be avoided, as they reduce the absorption of Diacerein. These substances can be used at another time (2 hours apart) after taking Galaxda 25 .
During the use of Galaxda 25, patients should pay attention to follow the instructions from the doctor and read the instructions carefully to achieve good results. In addition, patients are not allowed to arbitrarily change the way, dose or time of taking the drug without the permission of the doctor.
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