This is an automatically translated article.
Forclina 10mg is manufactured by Laboratorio Eczane Pharma S.A Company and registered by Bach Viet Pharmaceutical Co., Ltd. Drugs on the list of prescription drugs. So let's find out what Forclina 10mg is used for and how it is used through the article below.
1. What is Forclina 10mg?
Forclina 10mg medicine has the main ingredient containing the active ingredient Fludarabin phosphate with a concentration of 10mg, made in the form of film-coated tablets, packaged in a box of 3 blisters, each blister contains 5 tablets.
2. Indications of Forclina 10
Forclina 10mg is indicated for use in the following cases:
Treatment of chronic B-cell lymphoma (CLL) in patients with sufficient bone marrow reserve. Oral administration of Forclina 10 as first-line therapy should only be initiated in patients with advanced disease, Rai stages III and IV (Binet Stage C) or Rai stages I and II (Stage C). stages A and B according to Binet) when the patient has symptoms related to the disease or there is evidence that the disease is getting worse.
3. Usage and dosage of Forclina 10mg
3.1. Usage of the drug Forclina 10mg Forclina 10mg is produced in the form of film-coated tablets, used orally, the patient can take it on an empty stomach or with a full stomach. Patients should take the tablet with a glass of water, do not chew or crush the tablet. Forclina 10mg when used needs to be prescribed by a doctor who has experience in the use of drugs to treat cancer. 3.2. Dosage of Forclina 10mg Forclina 10mg is used at the recommended dose of 40 mg/m2 body surface area per day, for 5 consecutive days, every 28 days. In patients with renal impairment: reduce dose by up to 50% and monitor hematologic parameters closely to assess toxicity, if the patient has a clearance between 30 and 70 mL/min. Forclina 10 is contraindicated in patients with creatinine clearance < 30 ml/min. The duration of use of Forclina 10mg depends on the level of drug tolerance and the patient's treatment results. Usually about 6 consecutive cycles of treatment, patients can achieve maximum response, may be completely or partially cured, then the drug should be discontinued. The dose used for each patient is different and should be carefully adjusted according to the degree of hematological toxicity observed. If there is a very low decrease in platelet and neutrophil counts, the pre-set cycle of therapy should be delayed, delay should be extended to a maximum of 2 weeks, if there is still no improvement. Restoring the number of cell types requires dose reduction.
4. Undesirable effects of Forclina 10mg
During the use of Forclina 10mg, besides the therapeutic effects of the drug, patients also encountered the following undesirable effects:
Very common side effects: opportunistic infections, infections, anemia, neutropenia, thrombocytopenia, cough, nausea, vomiting, diarrhea, fatigue, fever, asthenia. Common side effects: Acute myelogenous leukemia, myelodysplastic syndromes, myelosuppression, anorexia, peripheral neuropathy, visual disturbances, stomatitis, skin rash, chills, malaise , mucosal edema. Uncommon side effects: Evan syndrome, autoimmune disorders, purpura, acquired hemophilia, Pemphigot's disease, tumor lysis syndrome, confusion, pulmonary toxicity, abnormalities in pancreatic enzymes , abnormal liver enzymes. Rare side effects: Lymphocyte proliferation disorder (EBV related), convulsions, fainting, agitation, optic neuropathy, blindness, optic neuritis, tachycardia, heart failure, Stevens Johnson syndrome, Lyell syndrome, skin cancer. It is recommended that patients immediately report to their doctor when experiencing any adverse effects during treatment with Forclina 10mg for quick and effective supportive treatment.
5. Forclina 10mg . drug interactions
The use of Ptostatin with Forclina 10mg is not recommended. The therapeutic efficacy of Forclina 10 may be reduced when co-administered with Dipyridamole and other Adenosine inhibitors. When the short-term treatment of Gentamycin in patients who have recently finished treatment with Forclina 10 has experienced severe neurotoxicity, treatment with Aminoglyeoside immediately following treatment with Forclina 10 is not recommended. The risk of infection is increased when corticosteroids are combined with Forclina 10 .
6. Notes when using Forclina 10mg
6.1. Contraindications of Forclina 10mg Do not use Forclina 10mg in the following subjects:
Patients with a history of hypersensitivity to Fludarabin and to any of the excipients of Forclina 10. Treatment is not indicated in patients with severe renal impairment (clearance less than 30 ml/min). Do not use in patients with anemia due to decompensated hemolysis. Do not use on pregnant women and nursing mothers. 6.2. Precautions when taking Forclina 10mg With caution when using Forclina 10mg in the following cases:
During the treatment with Forclina 10, the patient should have periodic blood cell tests in the peripheral area and be monitored. Monitor for hematologic toxicity, as well as the development of thrombocytopenia, neutropenia, and anemia. When treating patients with Forclina 10, it is necessary to monitor for signs of hemolysis. Forclina 10 must be discontinued when hemolysis occurs, because of life-threatening autoimmune events, even can cause death during treatment with Forclina 10 . Although there are no specific reports, however, it is necessary to monitor for signs of neurotoxicity in patients receiving Forclina 10mg. Possible neurotoxicity such as loss of concentration, blindness, convulsions, fainting, agitation. In patients with a large tumor burden who may experience tumor lysis syndrome when receiving Forclina 10, caution should be exercised in these patients during the first weeks of therapy. Forclina 10 should be used with extreme caution in debilitated patients once the risks and benefits of treatment have been assessed. Forclina 10 should be used with caution in patients with renal impairment or impaired renal function. There are no specific studies and reports on the elderly, caution should be exercised when any indications for the use of Forclina 10mg in this population.
7. Preservation of Forclina 10mg
Store Forclina 10mg in a cool, dry place, avoid direct sunlight and high temperature, because these agents can change the active ingredients and excipients in the product. medicine, appropriate storage temperature below 30 degrees C.
Patients need to read the instructions for use carefully before using, Forclina 10 is a prescription drug, it is recommended that patients absolutely follow the dose prescribed by the doctor. treat. Keep out of reach of children to avoid misuse.
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