Glasdegib: Uses, indications and precautions when using

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Glasdegib is indicated for the treatment of acute myeloid leukemia (AML). Glasdegib works by slowing or stopping the growth of malignant cancer cells.

1. What does Glasdegib do? Dosage like?

The prescription drug Glasdegib is indicated for use in the treatment of acute myeloid leukemia (AML). Take Glasdegib by mouth once a day, with or without food and as directed by your doctor.

2. How to use Glasdegib

How to use Glasdegib as follows:
Do not bite or chew the tablet when taking it. Dosage is prescribed based on your medical condition and response to treatment. If you vomit after taking a dose of Glasdegib, do not take another dose at that time, skip it and carry on with your work as usual. Do not increase the dose or arbitrarily use Glasdegib more often and for longer than prescribed, because the disease will not get better, but also increases the risk of side effects. You should take Glasdegib at the same time every day to increase the effectiveness of the treatment. Because Glasdegib can be absorbed through the skin and lungs, women who are pregnant or suspected of being pregnant should not use, or come into contact with, or breathe dust from the tablets.

3. Undesirable effects of Glasdegib

Like many other cancer drugs, Glasdegib can cause some side effects such as:
Nausea, vomiting, diarrhea, constipation, abdominal pain, dizziness, headache, change in appetite , loss of taste, loss of appetite, weight loss, joint pain or weakness, fatigue. You may also have pain or sores in your mouth and throat. Therefore, it is necessary to be careful when brushing your teeth, avoid using alcohol-containing mouthwash, and eat soft and liquid foods. Some people during treatment with Glasdegib may experience temporary hair loss. Hair will gradually grow back normally once the treatment is over. People taking Glasdegib may have some serious side effects. However, when your doctor prescribes this drug, it means that the benefits will outweigh the risk of side effects. Therefore, you need to follow your doctor's instructions. Tell your doctor if you have serious side effects such as: Easy bruising and bleeding; chest pain; change in the amount of urine; swelling of the hands, ankles, feet; pain and muscle spasms. Get emergency medical help if the patient has signs of a fast, irregular heartbeat, severe dizziness, or unconsciousness while using Glasdegib. Glasdegib may decrease the body's ability to fight infections. So tell your doctor right away if you have a fever, chills, sore throat.... Also, Glasdegib can cause a skin rash, but it's usually not too serious. However, it can be difficult to tell if it's a common rash or a sign of a serious allergic reaction, so tell your doctor right away if you notice a rash after taking Glasdegib.

4. Be careful when using Glasdegib

Before taking Glasdegib, tell your doctor if you are allergic to its ingredients or have any other allergic conditions. In addition, you should also:
List medical history to your doctor, especially if there are problems with infection, kidney, liver, heart, family history of heart disease such as QT prolongation on electrocardiogram , sudden death from heart disease. Glasdegib makes the user more susceptible to infections or can worsen an existing infection. Therefore, drug users should avoid contact with people who are suffering from infectious diseases such as influenza, measles, chickenpox... During the time of taking Glasdegib, do not vaccinate and avoid contact with people who have just received the vaccine. - Please live to reduce toxicity. Also, to reduce the risk of cuts, bruises or injuries, use caution when using sharp objects such as razors and nail clippers and avoid vigorous physical activity. Glasdegib medicine can cause prolonged QT syndrome causing rapid heart rate, serious confusion, dizziness, fainting ... To prevent the risk of QT syndrome when using Glasdegib medicine, inform your doctor. if you have frequent sweating, diarrhea, vomiting and a list of any medications you are taking (especially diuretics). You should not donate blood while taking Glasdegib. This is to prevent your blood from passing to the pregnant woman, affecting the health of the unborn baby. The elderly may be more sensitive to the side effects of Glasdegib, especially QT prolongation. It is not known whether Glasdegib passes into breast milk, but because of the possible risk to infants, breast-feeding should not be done during treatment and for 1 month after the last dose. Some medicines such as: Apalutamide; Azole antifungals (Itraconazole, Ketoconazole); Enzalutamide; Nefazodone; seizure medicine (Carbamazepine, Phenytoin); protease inhibitors (Ritonavir, Saquinavir); Rifamycins (Rifabutin, Rifampin); Telithromycin... can affect the elimination of Glasdegib from the body, affecting the treatment. Therefore, the patient needs to inform the doctor about the list of drugs he is taking.

5. Some notes when using Glasdegib

When using Glasdegib, patients should note:
If Glasdegib overdose and symptoms such as unconsciousness or difficulty breathing, the patient should be taken to the emergency room immediately. Perform periodic physical examination, including medical tests such as complete blood count analysis, electrocardiogram, assessment of liver and kidney function... to monitor disease progression and check for side effects. of drugs. A pregnancy test may also be ordered 1 week before you start using Glasdegib. If you miss a dose of Glasdegib, take it right away if it is more than 12 hours before your next dose. If less than 12 hours skip the missed dose and take it at your usual schedule. Store Glasdegib at room temperature, away from light and moisture. Keep Glasdegib out of the reach of children and the reach of pets. In summary, Glasdegib is indicated for the treatment of acute myeloid leukemia (AML). The correct use of Glasdegib will help increase the effectiveness of the treatment and reduce the side effects of the drug. Therefore, you need to follow the instructions of your doctor.

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Reference source: Webmd