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Fada Carboplatino is a drug with the main active ingredient Carboplatin, an alkylated substance. The drug has cytotoxic and antitumor effects, most used for ovarian cancer.
1. What does Fada Carboplatino do?
Fada Carboplatino is a lyophilized powder for injection and is used for intravenous infusion. With the main ingredient is Carboplatin, the drug is produced in 2 forms:
Carboplatin 150mg bottle contains 150mg Carboplatin and 150mg Manitol. Carboplatin 450mg vial contains 450mg Carboplatin and 450mg Manitol. Fada Carboplatino is a white lyophilized powder that comes in an amber glass vial that is sealed with a rubber stopper, aluminum cap and flip cap.
Fada Carboplatino drug has cytotoxic and anti-cancer effects, widely used in the treatment of ovarian cancer.
Carboplatin components and metabolites are excreted mainly by the kidneys by glomerular filtration and excreted in the urine.
Fada Carboplatino is indicated for use in the following cases:
From stage IV, after surgery, recurrence or metastasis after ovarian cancer treatment. Treatment of diseases related to lung cancer such as small cell lung cancer, non-small cell lung cancer. Used in head and neck cancer, brain tumor, neuroblastoma, testicular cancer, advanced and recurrent retinoblastoma in children. In addition, some of the following cases have contraindications to the use of Fada Carboplatino:
Patients with severe myelosuppression, severe renal failure. Subjects using the drug are pregnant and lactating women. Patients with hypersensitivity reactions to drugs containing platinum and other components of the drug formulation.
2. How to use and dose Fada Carboplatino
How to use: Fada Carboplatino is administered intravenously. The drug can be infused over 15 minutes or longer and can be continued for 24 hours. In addition, Fada Carboplatino is also used by the peritoneal route.
Dosage: Depends on clinical response, tolerability and toxicity, ensuring optimal therapeutic results with minimal adverse effects.
The starting dose depends on body surface area and is calculated based on the patient's renal function. Each patient will have their own dose of medication.
In case of overdose of Fada Carboplatino, the patient will appear many toxic manifestations, the most severe is marrow failure and hepatotoxicity. The latter is toxic to the kidneys, nerves, digestive system and hearing.
Currently, there is no drug that can specifically detoxify the overdose of Fada Carboplatino. Treatment is to stop the drug and treat the symptoms of hypersensitivity reactions with intravenous drugs such as corticosteroids, antihistamines, and Epinephrine. To combat bone marrow failure requires blood transfusion or separate transfusion of platelets and red blood cells and use of drugs that stimulate white blood cells.
3. Side effects of the drug Fada Carboplatino
Fada Carboplatino drug often causes very serious complications for users. The most dangerous adverse event affecting drug use is bone marrow failure, which is common in patients who have received previous anticancer drugs or radiation therapy or have kidney failure. Besides, in the process of taking the drug, patients may experience gastrointestinal, neurological, ear, eye and kidney complications which are also quite common. The degree of influence depends on the dose, the way of using the drug alone or in combination, the liver and kidney function and the location of each patient.
Common side effects:
Effects on blood: Manifestations of bone marrow failure. The first is thrombocytopenia, followed by leukopenia and anemia. Effects on digestion: Patients may have nausea and vomiting, abdominal pain, diarrhea, stomach ulcers, constipation,... Nerve effects: The drug can cause paresthesias of extremities, muscle tremors, loss of taste, convulsions, cramps, central nervous system toxicity, peripheral neurotoxicity, human pain, weakness, pain in tumors,... Fada Carboplatino drugs also cause side effects in the ears, kidneys, and liver. , cardiovascular disease with the following manifestations: tinnitus, hearing loss, increased blood creatinine, increased liver enzymes, increased alkaline phosphatase, heart failure, thrombosis, cerebrovascular disease,... In addition, Fada Carboplatino drug also causes damage renal tubular necrosis or degeneration, interstitial edema, allergic reactions such as skin rash, urticaria, rash and hair loss, necrosis at the injection site if the drug is injected extravascularly. Few and rare side effects:
Systemic effects: Causes hypotension, anaphylactoid reactions. Effects on the heart: Fada Carboplatino has severe cardiac toxicity leading to death, but it is not clear if it is caused by the carboplatin component of the drug or not. Effects on breathing: Causes bronchospasm. Effects on eyes: Causes vision loss in patients with varying degrees. When using Fada Carboplatino in combination with other drugs, it may cause complications with a higher rate and severity.
4. Notes when using Fada Carboplatino
Fada Carboplatino is a very toxic drug with a low therapeutic index. If toxicity does not occur, it indicates no response to treatment. Therefore, the drug is only used under the close supervision of a specialist and has the means to handle complications during the use of Fada Carboplatino. Regularly check the blood count test once a week to check the blood cell lines because the drug can cause bone marrow depression. Closely monitor the patient's renal function by determining creatinine clearance. In case of severe renal failure, the drug should not be used to treat. In elderly patients, Fada Carboplatino is more likely to be neurotoxic and cause peripheral neuropathy, renal failure, and bone marrow failure. Fada Carboplatino drug is toxic to the fetus, so do not use the drug for this object. However, in the case of a life-threatening patient for which other treatments are ineffective, the use of Fada Carboplatino may be considered. Current studies do not indicate whether Fada Carboplatino is excreted in human milk. However, this is a drug that is very toxic to children. Therefore, if the mother uses the drug, she should stop breastfeeding. In summary, Fada Carboplatino is a cytotoxic drug, used to treat cancer, especially ovarian cancer. This is a prescription drug, patients can only use it under the close supervision of a specialist and need to regularly check the paraclinical indicators to monitor the progress of the disease.
