Lynparza drug: Uses, indications and precautions when using

This is an automatically translated article.

Lynparza is commonly used to treat ovarian cancer and some other cancers. Lynparza slows the growth of cancer cells.

1. Indications and contraindications of the drug Lynparza

Lynparza is indicated in the following cases:
Ovarian cancer in patients with BRCA gene mutations. Primary peritoneal cancer. Fallopian tube cancer Carcinoma of the ovary Metastatic breast cancer germline BRCA , HER2 negative. Pathogen of metastatic pancreatic carcinoma BRCA mutation. HRR-gene mutations in metastatic castration-resistant prostate cancer. Contraindications of Lynparza drug include:
Acute myeloid leukemia . Interstitial pneumonia Myelodysplastic syndrome, a bone marrow disorder. Pregnancy Women who are breastfeeding. Chronic kidney disease stage 3A, 3B (moderate).

2. How to use Lynparza

Read the medication guide provided by your doctor before you start taking Lynparza and each time you get a refill. If you have any questions about how to use Lynparza, ask your doctor.
Lynparza is also available in tablet form. Do not take the tablet form in place of the capsule unless your doctor tells you to, because they do not work the same way.
Take Lynparza by mouth with or without food as directed by your doctor, usually twice daily. Swallow the tablet whole, do not chew, dissolve or open the capsule. Do not take capsules that are damaged or look like they are leaking.
Avoid eating grapefruit or drinking grapefruit juice while using Lynparza unless your doctor says you can safely do so. Also avoid eating Seville oranges (usually found in marmalade). Grapefruit and Seville oranges may increase the risk of Lynparza side effects.
The dose of Lynparza is calculated based on your medical condition and response to treatment.
Do not increase your dose or use Lynparza more often or for longer than prescribed by your doctor. Doing so will not help your condition improve faster, but will also increase your risk of serious side effects.
Because Lynparza can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or may become pregnant should not use or breathe dust from the capsules of this medicine.
Tests such as a complete blood count should be performed periodically to monitor your progress or check for Lynparza side effects.

3. Side effects of Lynparza

During treatment with Lynparza, you may experience nausea, vomiting, loss of appetite, diarrhea, constipation, an unpleasant taste in your mouth, dizziness, or joint/back/muscle pain. Rarely, Lynparza can cause severe nausea and vomiting.
In some cases, your doctor may prescribe a combination medicine to prevent or reduce nausea and vomiting. Eating small meals or limiting activity after eating can help reduce nausea and vomiting. If any of these side effects persist or get worse, tell your doctor right away.
Remember that your doctor has prescribed Lynparza for you because they have judged that the benefit to you outweighs the risk of side effects. Many people use Lynparza and no serious side effects occur.
Tell your doctor right away if you have any serious side effects of Lynparza, including: Signs of kidney problems (such as change in the amount of urine), swelling of the hands/ ankle/foot.
Lynparza reduces bone marrow function, an effect that can lead to low numbers of blood cells such as red blood cells, white blood cells, and platelets. This side effect can cause anemia, decreased ability to fight infection, or easy bruising/bleeding. However, rarely these problems can be symptoms of bone marrow or blood cell cancer that is very serious and potentially fatal, especially if you have had radiation or chemotherapy for cancer. ovarian letter.
Your doctor will monitor your blood cell count. Tell your doctor right away if you have any of the following symptoms: Signs of anemia (such as unusual tiredness, pale skin, rapid breathing, fast heartbeat), signs of infection ( such as fever, chills, persistent sore throat), easy bruising or bleeding (such as pink/bloody urine, black/bloody stools), weakness, weight loss.
Get medical help right away if you have any very serious side effects of Lynparza medicine, including: New/worsening trouble breathing, coughing, wheezing.
A very serious allergic reaction to Lynparza is very rare. However, if you notice any symptoms of a serious allergic reaction to Lynparza, including: Rash, itching/swelling (especially of the face/tongue/throat), trouble breathing, dizziness, Get medical help right away.
Below are Lynparza side effects by likelihood.
Common side effects of Lynparza include:
Thrombocytopenia in the blood Low white blood cell count Low neutrophil count Decrease in the number of lymphocytes in the blood Anemia Sore throat Common cold Indigestion Constipation Inflammation skin Joint pain Back pain Muscle pain Low energy Taste loss Decreased appetite Headache Cough Nausea Vomiting Diarrhea Severe abdominal pain Less common side effects of Lynparza include:
Low blood magnesium Figure blood clots in the veins Hypersensitivity reactions to drugs Depression Peripheral neuropathy High blood pressure Stomatitis Eczema Itching Dry skin Dizziness Difficulty sleeping Fever Fever Fluid retention in hands and feet. Temporary facial and neck redness Difficult or painful urination Unintentional leakage of urine High blood sugar Vulvar inflammation Anxiety rare side effects of Lynparza include:
Acute myeloid leukemia One blood blood clots in the lungs Interstitial pneumonia Erythema Myelodysplastic syndrome, a type of bone marrow disorder. Angioedema This is not a complete list of possible side effects of Lynparza. If you notice other side effects of Lynparza medicine not listed above, contact your doctor immediately for prompt treatment.

4. Measures to prevent side effects of Lynparza

Before taking Lynparza, tell your doctor if you are allergic to this medicine and any other allergies, if any. Lynparza products may contain inactive ingredients that may cause allergic reactions or other problems.
Before using Lynparza, tell your doctor your medical history, especially of: Kidney disease.
Lynparza may make you more susceptible to infections or worsen any existing infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that can spread to others (such as chickenpox, measles, flu).
Do not have any vaccinations/vaccinations during treatment with Lynparza, without your doctor's consent. Avoid contact with people who have recently received a live attenuated vaccine such as the nasal flu vaccine.
Lynparza can make you dizzy and alcohol and marijuana can make you more dizzy. Do not drive, use machines, or do anything that requires alertness during treatment with Lynparza, until you can do so safely.
Before surgery, tell your doctor or dentist that you are being treated with Lynparza.
Tell your doctor if you are pregnant or plan to become pregnant before using Lynparza. You should not become pregnant while using Lynparza, because it can harm an unborn baby. Men with female partners of childbearing age should use reliable forms of birth control while using Lynparza and for at least 3 months after stopping treatment. In addition, men should not donate sperm while using this medicine and for 3 months after stopping treatment.
Women of childbearing age should ask about reliable forms of birth control while using Lynparza and for at least 6 months after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of Lynparza for your unborn baby.
Because the drug can be absorbed through the skin and lungs and can harm an unborn baby, women who are pregnant or may become pregnant should not use Lynparza or breathe dust from the capsules.
Currently, it is not known whether Lynparza passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using Lynparza and for at least one month after stopping treatment.

5. Interactions of Lynparza . drugs

Drug interactions can change the way Lynparza works or increase your risk of serious side effects. Tell your doctor about all the medicines you use (including prescription/nonprescription drugs and herbal products). Do not start, stop, or change the dose of any medicine while you are being treated with Lynparza, without your doctor's approval.
Other drugs may affect the removal of Lynparza from your body, which may affect how it works. Such drugs include carbamazepine, phenytoin, rifamycins (such as rifampin), St. John's wort.

6. What to do if you overdose or forget to take Lynparza?

If you or someone else has overdosed on Lynparza and has severe symptoms such as fainting or difficulty breathing, call 911 immediately.
If you miss a dose of Lynparza, take it as soon as you remember. If you find out when it is almost time for your next dose, skip the missed dose. Take your next dose of Lynparza at the usual time, do not double your usual dose.

7. How to store the medicine Lynparza

Store Lynparza in the refrigerator, do not freeze the medicine. If needed, Lynparza can be stored at room temperature away from light and moisture for up to 3 months, not in the bathroom, away from children and pets.
Do not use Lynparza if it has been exposed to temperatures above 104 degrees F (40 degrees C) or if it has been frozen. Dispose of the medication appropriately when it expires or it is no longer needed by you.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.

Reference source: webmd.com,