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Esseil 5 is prepared in the form of film-coated tablets with the main ingredient Cilnidipine. Esseil 5 is indicated for use with a doctor's prescription in cases of hypertension.
1. What is Esseil 5?
Esseil 5 is a product of Dat Vi Phu Pharmaceutical Joint Stock Company. Esseil 5 is prepared in the form of film-coated tablets with the main ingredient Cilnidipine, 5mg content. Several studies regarding the efficacy of the active ingredient Cilnidipine:
Antihypertensive effect of Cilnidipine in patients with essential hypertension: A single daily oral dose of cilnidipine has shown a hypotensive effect. maintained for 24 h and this antihypertensive effect was still evident early the next morning. Cilnidipine does not increase sympathetic activity or increase heart rate as a reflex response to a decrease in blood pressure; In healthy adult male volunteers whose blood pressure increased by 20% or more in the cold stress trial, it was found that: Cilnidipine inhibited the increase in blood pressure induced by cold stress; In spontaneously hypertensive rats undergoing lumbar puncture, Cilnidipine inhibited the process of hypertension induced by electrical sympathetic stimulation; In patients whose hypertension tends to be further complicated by cerebrovascular disease, the patient's cerebral blood flow is maintained while blood pressure is reduced with Cilnidipine; In patients with essential hypertension, Cilnidipine has no effect on heart rate while still providing a blood pressure lowering effect; In patients with an abnormal heart-to-chest ratio (CTR), Cilnidipine improves the heart-to-chest ratio; In patients with essential hypertension, Cilnidipine did not affect renal function while blood pressure was still effectively reduced; In patients with essential hypertension, the active ingredient cilnidipine reduces the atherosclerotic index and serum lipid peroxide. Cilnidipine works by binding to dihydropyridine binding sites of L-type voltage-dependent calcium channels. This inhibits Ca2+ influx across the cell membrane of vascular smooth muscle, causing vascular smooth muscle to relax, causing vasodilation and hypotensive effect. Cilnidipine also inhibits Ca2+ influx through N-type voltage-dependent calcium channels in the membranes of sympathetic neurons, this inhibition occurring over a range of drug concentrations similar to those that inhibit Ca2+ channels. belonging to the type L potential mentioned above. Thus, norepinephrine release from sympathetic nerve endings is inhibited, leading to inhibition of the reflex increase in heart rate following hypotension and suppression of stress-related hypertension through this same mechanism.
2. Indications and contraindications of Esseil 5
2.1. Indications Esseil 5 is indicated for use in the treatment of hypertension.
2.2. Contraindications Esseil is contraindicated in the following cases:
Patients with hypersensitivity to this active ingredient or any of the ingredients of Esseil 5. Pregnant women or women who may be pregnant.
3. Dosage of the drug Esseil and how to use it
Dosage of Esseil is as follows:
Adults: use Esseil at a dose of 5-10mg/time/day. The dose of Esseil can be adjusted according to the age and symptoms of the patient, in some cases the dose can be increased to 20 mg/time/day. People with severe high blood pressure: use Esseil at a dose of 10-20mg/time/day. Medicine Esseil 5 is taken orally, taken once a day, taken after breakfast.
An overdose of Esseil 5 may cause an excessive decrease in blood pressure. If there is a marked decrease in blood pressure after taking Esseil, appropriate measures should be taken such as: elevating the lower extremities, administering intravenous fluids and using drugs that increase blood pressure. Elimination of Esseil by hemodialysis is ineffective due to its high protein binding rate.
4. Drug interactions of the drug Esseil
Using Esseil 5 with other antihypertensive drugs will have additive or synergistic effects on lowering blood pressure excessively; Digoxin: calcium channel blocker increases the concentration of digoxin in the blood plasma; Cimetidine : increases the absorption of calcium antagonists such as Esseil 5 . Caused by cimetidine reducing blood flow through the liver, preventing the metabolism of calcium channel blockers by enzymes in the liver microsomes; Rifampicin: reduced effect of Esseil 5 drug by liver drug metabolizing enzyme (cytochrome P450) induced by rifampicin, promoting drug metabolism Esseil 5. Antifungal azole group such as itraconazole, miconazole... increased drug concentration of Esseil 5 in plasma because azole group inhibits CYP3A4 drug-metabolizing enzyme.
5. Side effects of Esseil
Clinically significant side effects of Esseil 5:
Liver dysfunction, jaundice with increased AST (GOT), ALT (GPT) and γ-GTP may occur; Thrombocytopenia may occur, so close monitoring is required. If there is any abnormality, Esseil 5 should be discontinued. Other common Esseil 5 side effects:
Liver: increased liver enzymes ; Kidney: increased creatinine, increased urea nitrogen, protein in the urine; Nervous: headache, dizziness, stiff shoulder; Heart: flushing, palpitations, feeling of heat, abnormal electrocardiogram, decreased blood pressure; Gastrointestinal: nausea/vomiting, abdominal pain; Hypersensitivity: rash; Hematology: Increase or decrease in white blood cells and hemoglobin; Other reactions: Edema, general malaise, urinary incontinence, increased cholesterol, increased or decreased CK (CPK), uric acid, potassium and serum phosphorus.
6. Be careful when using Esseil 5
Use Esseil 5 with caution in the following cases:
Patients with severe liver dysfunction: plasma concentrations of Esseil may be increased; People with a history of serious adverse reactions to calcium channel blockers; When reducing the dose of Esseil 5, it is necessary to closely monitor, replace it with other antihypertensive drugs, do not stop Esseil 5 without the guidance of a doctor; Elderly: Esseil 5 should be used carefully under close supervision, should be used at a low starting dose to avoid excessive hypotensive effects in the elderly; There is no experience with the safety of Esseil 5 in children; Care should be taken when driving or operating machinery because Esseil 5 can cause dizziness and lightheadedness due to low blood pressure. Esseil 5 is a film-coated tablet with the main ingredient Cilnidipine. Esseil 5 is indicated for use with a doctor's prescription in cases of hypertension. During use, patients should strictly follow the instructions of the doctor and pharmacist.
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