This is an automatically translated article.
Antihistamine H1 is a group of drugs used relatively widely, especially in patients with allergic rhinitis or chronic urticaria. One of the products in this group of drugs is Ebastin 20mg. So what is Ebastine 20mg and how to use it?1. What is Ebastine?
Ebastine 20mg contains the main active ingredient Ebastine, which belongs to the group of antihistamines.
2. Indications of Ebastine 20mg
Ebastine is indicated for use in the following cases:
Allergic rhinitis (including seasonal or year round), with or without allergic conjunctivitis; Chronic idiopathic urticaria; Treatment of symptoms of atopic dermatitis. Ebastine 20mg is contraindicated for use in the following cases:
People who are allergic or hypersensitivity to Ebastine 20mg or any other ingredients of the drug; Severe liver failure.
Ebastine 20mg cần được sử dụng theo chỉ định của bác sĩ
3. Dosage and how to use Ebastine 20mg
Dosage in adults:
Allergic conditions related to histamine: 10mg/day; Allergic rhinitis or chronic urticaria: 10mg/day; Seasonal allergic rhinitis: Ebastin 20mg/day. Dosage in children;
Children over 12 years old: The same dose as adults; Children under 12 years of age should not use Ebastine.
4. Ebastine side effects
Common side effects include:
Headache ; Drowsiness; Dry mouth . Some less common side effects:
Insomnia ; Dizzy; Sore throat; Nosebleeds, rhinitis; Nausea, abdominal pain, indigestion; Attenuate . In addition, some rare effects when using ebastine, including:
Anxiety, dysesthesia; Tachycardia, palpitations, palpitations; Vomiting; Abnormalities in liver function tests; Rash, hives or eczema; Dysmenorrhea ; Edema.
5. Some notes when using Ebastine
General notes:
Use Ebastine with caution in patients with conditions such as prolonged QT syndrome, hypokalemia, taking drugs that can prolong the QT interval or inhibit isoenzyme CYP3A4; Ebastine should be used with caution in patients with mild to moderate hepatic impairment and renal impairment of all degrees; The safety and effectiveness of Ebastine in children under 12 years of age have not been established. Note for special subjects:
Ebastin 20mg products should not be used by pregnant women, only when the benefits to the mother's health outweigh the possible risks to the fetus; The use of Ebastine is not indicated for women who are breastfeeding; Ebastin 20mg may cause drowsiness side effects, so it is not suitable for drivers to drive and operate machinery.
Người bệnh nên thận trọng với một số lưu ý khi dùng thuốc Ebastin 20mg
6. Pharmacodynamics and pharmacokinetics of Ebastine
6.1. Pharmacodynamics Ebastine belongs to the second generation antihistamine group, after entering the body, it will be metabolized to form the active substance Carebastine.
Both in vitro and in vivo studies have shown the antihistamine and antiallergic effects of Ebastine. The advantage of this active ingredient is its long-lasting effect and low sedation, and in vivo studies show that Ebastine preferentially binds to peripheral H1 receptors.
According to studies, Ebastine is an effective anti-allergic and anti-histamine drug in healthy volunteers and allergic patients, in addition to its ability to inhibit histamine-induced bronchoconstriction. out in asthmatic patients. Ebastine 20mg also significantly improves symptoms of seasonal/year-round allergic rhinitis or chronic idiopathic urticaria.
Most of the new generation H1-receptor antagonists do not cause tissue accumulation when administered consecutively and remain effective for 3 days for short courses of treatment. In addition, observations in patients receiving Ebastine 20 mg daily on a regular basis did not show tolerance or loss of peripheral H1-antagonism.
6.2. Pharmacokinetics Absorption: After oral administration, Ebastin 20mg is rapidly and almost completely absorbed from the gastrointestinal tract. In subjects taking a single dose of 10 mg, the time to peak plasma concentrations of the metabolite Carebastine (80-100 ng/ml) was approximately 2.6 to 4 hours. Note that when using Ebastine with food, it may increase the bioavailability of the drug; Distribution: Ebastine can cross the placenta and is excreted in human milk. Both Ebastine and Carebastine are strongly bound to plasma proteins with binding rates above 95%; Metabolism: This active substance is almost completely metabolised in the liver via the CYP3A4 enzyme system to the active metabolite Carebastine Acid; Elimination: 2⁄3 of the drug is excreted in the urine mainly as conjugated metabolites. The half-life of Carebastine ranges from 15–19 hours, which can be increased to 23–26 hours in patients with renal impairment and up to 27 hours in patients with hepatic impairment.
7. Some drug interactions of Ebastine
Concomitant use of Ebastine with azole antifungals (eg Ketoconazole) or macrolide antibiotics (eg Erythromycin, Clarithromycin) may lead to increased plasma concentrations of Ebastine and prolongation of the QT interval; Concomitant use of Ebastin 20mg with antiarrhythmic drugs may increase the risk of developing tachycardia; The sedative effects of alcohol and Diazepam may be increased when used in combination with Ebastine; Co-administration of Ebastine with food may increase its bioavailability. In summary, Ebastine is often used to treat dermatitis, seasonal allergic rhinitis or chronic urticaria. The information provided is not a substitute for medical professional advice. Always consult your doctor or pharmacist before you use the medicine.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
