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Dozidine MR 35mg contains the active ingredient Trimetazidine, used to support the treatment of stable angina. Complying with the indications and dosage of Dozidine MR 35mg will help patients improve treatment effectiveness and avoid unwanted side effects.
1. What is Dozidine MR 35mg?
Dozidine MR 35mg is a drug used to support the treatment of stable angina with the main active ingredient being Trimetazidine. The drug is manufactured in the form of slow-release film-coated tablets, each tablet includes 2 ingredients:
Trimetazidine dihydrochloride: 35mg. Excipients: just enough.
2. The effect of the drug Dozidine MR 35 mg
Mechanism of action of the drug Dozidine:
Dozidine 35 (Trimetazidin 35mg) has the effect of inhibiting the long-chain 3-ketoacyl-CoA thiolase enzyme in ischemic cells, thereby inhibiting the beta-oxidation of cells. fatty acids. Thereby promoting the oxidation of glucose to generate energy, helping to optimize cellular energy processes, thus maintaining optimal energy metabolism during anemia. Since the energy obtained in glucose oxidation requires less oxygen consumption than in beta oxidation. Pharmacodynamic effects of Dozidine:
In patients with ischemic heart disease, Dozidine (Trimetazidine) acts as a metabolite, helping to preserve high intracellular phosphate energy levels in cardiomyocytes. Trimetazidine has both anti-ischemic effects but does not affect the hemodynamics of organs.
3. Uses of Dozidine MR 35 mg
With the main effect of anti-ischemic for cardiomyocytes, the use of Dozidine MR 35mg is often used in the following cases:
Patients with stable angina that is not adequately controlled or intolerant with other angina therapies.
4. Dosage and how to use Dozidine MR 35 mg
Dosage: Dozidine MR 35mg is used with the following dosage:
Usual dosage: Take 1 tablet/time x 2 times/day. Patients with moderate renal impairment (creatinine clearance: 30 - 60 ml/min): The recommended dose is 1 tablet x 1 time/day in the morning, taken with meals. Elderly Patients: Due to age-related decline in renal function, elderly patients may have a higher than normal level of trimetazidine sensitivity. Children: The safety and effectiveness of trimetazidine have not been evaluated in patients under 18 years of age, so for this population, it is necessary to consult a specialist before using it to find the right dose. fit. The dose of Dozidine MR 35mg may vary from patient to patient, disease level, physical condition, age, .... Therefore, patients need to strictly follow the doctor's instructions. Do not arbitrarily change the dose, that may affect the health and effectiveness of the drug.
How to use: Dozidine Mr 35mg is taken orally, with meals. The patient should swallow the tablet whole, do not break, chew or crush the tablet because that will affect the effect of the drug.
5. Undesirable effects when using Dozidine
Common undesirable effects when using Dozidine include: Dizziness, headache, abdominal pain, diarrhea, dyspepsia, nausea and vomiting, rash, urticaria, body weakness. Rare adverse effects when using Dozidine include: Palpitations, palpitations, arrhythmias (extrasystole, tachycardia, ..), hypotension, orthostatic hypotension... Some Other undesirable effects of the drug Dozidine Mr 35mg: Patients may show symptoms of Parkinson's disease with the following manifestations: Tremor, slow and difficult movement, increased muscle tone; unsteady gait, other related movement disorders, or sleep disturbances (insomnia, poor sleep, etc.). In addition, the following conditions may appear: Constipation, acute generalized exanthematous pustulosis (AGEP), angioedema, thrombocytopenic purpura or hepatitis... During the course of taking the drug, if you have Manifestations of one of the undesirable effects of Dozidine MR 35 mentioned above, or other undesirable symptoms not mentioned, should immediately notify the treating doctor/pharmacist for advice and guidance. and prompt treatment.
6. Notes when using Dozidine MR 35mg
When using Dozidine MR, you should note the following information:
Dozidine MR 35mg is contraindicated in the following cases:
People with hypersensitivity to any of the ingredients in Dozidine. Patients with Parkinson's disease, or Parkinson's symptoms such as: Tremor, restless legs syndrome, or other related movement disorders,... End stage renal failure. Use with caution: Dozidine MR may cause or worsen symptoms of Parkinson's disease. Therefore, for these patients, especially elderly patients, they need to be checked, evaluated and monitored regularly. Dozidine MR (Trimetazidin) can cause symptoms such as dizziness, drowsiness, not alertness, ... Therefore, the drug may affect the ability to drive and use machines. Subjects: Pregnant women, women in the lactation period: Through the results of animal studies, it is not certain whether or not it affects the pregnancy process, or the health of the fetus. Mother and baby. Therefore, Trimetazidine should not be used in these subjects.
7. Drug interactions Dozidine Mr 35mg
Up to now, through studies, there have been no drug interactions with Dozidine.
Above is some information about the use of Dozidine MR 35mg. If you need advice or have any questions, please consult a qualified doctor/pharmacist for answers.
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