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Doxapram is a respiratory stimulant, with the main active ingredient is Doxapram, content of 2ml/ml for infusion or 20mg/ml for solution for injection. Uses and how to use Doxapram specifically, you can refer to the article below.
1. Indications for use of Doxapram
Doxapram is indicated for use in the following cases:
Acute respiratory failure; After anesthesia. Uses:
Doxapram is a central nervous system stimulant, stimulating peripheral chemical receptors in the carotid sinus. The main pharmacological effect of Doxapram hydrochloride is an increase in minute ventilation due mainly to an increase in tidal volume and an increase in respiratory rate (less effective). Doxapram is used to stimulate ventilation in patients whose clinical condition indicates severe hypercapnia during controlled oxygen therapy. In addition, the drug is used to stimulate ventilation in patients presenting with progressive hyperPCO2 with altered mental status during or after controlled oxygen therapy. Doxapram stimulates ventilation in the postoperative period as an adjunct to reduce postoperative pulmonary complications. It also supports the use of narcotic analgesics (opioids) in effective doses without causing respiratory depression.
2. Contraindications to the use of Doxapram
Doxapram is contraindicated in the following cases:
Patients with a hypersensitivity reaction to the active ingredient doxapram or to any of the excipients contained in the drug. Severe hypertension. Acute asthma attack. Coronary artery disease. Epilepsy and other seizure disorders. Cerebral edema. Stroke . Thyroid disease: Hyperthyroidism / Thyroid toxicity. Physical obstruction of the airways, which limits movement of the chest wall, respiratory muscles, or the ability of the alveoli to expand. Patients with traumatic brain injury. Suspected pulmonary embolism.
3. Dosage and how to use Doxapram
Doxapram dosage in the treatment of acute respiratory failure for adults and children over 12 years: The recommended dose is 1.5 to 4 mg/min depending on the patient's condition and response. Use infusion. Assess by regular monitoring of blood gas status.
Dosage in the treatment of respiratory depression after surgery: Administer intravenously. The recommended dose of Doxapram is 1.0 to 1.5 mg/kg administered over a period of at least 30 seconds, possibly repeated 1 hour apart. If the patient does not respond. Note: Maximum total dose: 2mg/kg, do not exceed 3g in 24 hours.
4. Doxapram . side effects
When taking the drug Doxapram may have the following side effects:
Fever, sweating; Increased salivation ; Dizzy; Illusion; Headache ; Convulsions; Bronchospasm and difficulty breathing. The above may not have mentioned all the side effects of Doxapram, so during the course of taking the drug, if you experience any unpleasant or unusual symptoms, please notify your doctor immediately.
5. Notes when taking Doxapram
Doxapram hydrochloride should be administered concurrently with oxygen to patients with severe irreversible airway obstruction or severely impaired lung compliance because the drug increases respiratory function in these patients. For patients with bronchospasm, always use Doxapram hydrochloride in combination with bronchodilators β-adrenoceptor to reduce the work of breathing in the patient. Caution should be exercised in patients with hepatic dysfunction as Doxapram hydrochloride is extensively metabolised by the liver. In patients receiving sympathomimetic agents concomitantly with doxapram hydrochloride should be used with caution because of possible additive sympathomimetic effects. Patients receiving monoamine oxidase inhibitors with doxapram hydrochloride should be used with extreme caution as animal studies have shown that the effects of doxapram are enhanced following treatment with monoamine oxidase inhibitors. (MAOI). In patients receiving anesthesia when combined with Doxapram may cause increased myocardial sensitivity to catecholamines. Initiation of Doxapram hydrochloride treatment should be delayed for at least 10 minutes after discontinuation of the above anesthetics because an increase in adrenaline release has been observed with Doxapram. Doxapram hydrochloride should be used with caution in patients with severe metabolic disorders such as in pheochromocytoma. If a patient develops a sudden severe increase in blood pressure or shortness of breath develops, doxapram hydrochloride should be discontinued. Blood pressure and tendon reflexes should be monitored to avoid overdose of Doxapram. To avoid side effects when taking Doxapram should use the minimum effective dose. Doxapram should not be co-administered with patients on ventilators. Although there is no documented risk, Doxapram is not recommended for use during pregnancy unless there is a compelling clinical reason for its use. Physicians must weigh the benefits and risks. Use with caution in pregnant and lactating women because it is not known whether Doxapram is excreted in human milk or affects the fetus.
6. Doxapram drug overdose
When overdose of the drug Doxapram can lead to increased blood pressure, increased heart rate, other arrhythmias, increased tendon reflexes and dyspnea. Serious symptoms of overdose may include generalized seizures and convulsions.
Treatment of Doxapram Overdose:
Use Diazepam, Phenytoin and Short-acting Barbiturates, oxygen and resuscitation equipment to control overdose. In case of overdose when using Doxapram, it is necessary to notify the doctor immediately if the above serious and unpleasant symptoms appear for timely treatment.
7. Missed dose of Doxapram and handling
Doxapram is prescribed by specialists and used by medical personnel. Therefore, if the patient needs to consult the doctor if the dose is suspected.
In summary, Doxapram is a respiratory stimulant. Medicines are taken as prescribed by a doctor and by medical staff. To be sure to use Doxapram safely, correctly and in the correct dosage, you need to consult with your doctor / pharmacist. Note, Doxapram is a prescription drug, you absolutely should not buy and treat it at home because you may experience side effects and dangerous drug interactions.
