Uses of Dobusafe

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1. What is Dobusafe?

What is Dobusafe? Dobusafe medicine has the main active ingredient, Dobutamine, 125mg and other excipients in sufficient quantity. This is a cardiovascular drug that is used in the treatment of progressive myocardial insufficiency: myocardial infarction, after open-heart surgery,...
Dobusafe is prepared in the form of an infusion solution. Packing is a medicine box with 1 vial containing 20ml.
1.1. Pharmacodynamics of the active ingredient Dobutamine Pharmacokinetics Dobutamine is a beta 1-adrenergic agonist, a heart stimulant.
1.2. Pharmacokinetics of the active ingredient Dobutamine Absorption: Dobusafe is prepared as a solution for intravenous infusion, the effect appears quickly, after about 1 to 10 minutes. The concentration of the active ingredient peaks in about 10-20 minutes. Metabolism: Active substance Dobutamine is metabolised in the liver and tissues to inactive metabolites, mainly conjugates of Dobutamine and 3-O-methyl dobutamine. Elimination: The metabolites are excreted in the urine. 1.3. Active ingredient Dobutamine Active ingredient Dobutamine is a synthetic catecholamine, an inotropic agent of choice for short-term circulatory support in end-stage heart failure. Dobutamine is less likely to cause tachycardia and arrhythmias than endogenous catecholamines or isoproterenol. Drugs reduce preload, drugs reduce afterload even more.
At comparable inotropic doses, dobutamine increases the autonomic function of the sinus node to a weaker extent than isoproterenol. However, the effect of increasing atrioventricular and intraventricular conduction is similar for the two drugs.

2. What are the effects of Dobusafe?

What does Dobusafe drug do? Dobusafe is used to treat the following conditions:
Progressive myocardial insufficiency, specifically as treatment for myocardial infarction, after open-heart surgery, severe pulmonary embolism or shock caused by poisoning poison. Used alone or in combination in reducing cardiac output. Circulatory failure is not a cardiac cause. Used as a test in diagnostic procedures for ischemic heart disease.

3. Usage and dosage of Dobusafe

Usage and dosage of the drug Dobusafe as follows:
3.1. How to use Dobusafe drug Dobusafe drug is prepared as a solution for infusion, suitable for intravenous use.
3.2. Dosage of the drug Dobusafe Dilute 1 vial with 20ml of 5% Glucose solution, further mix in 250 - 500mL of 5% Glucose solution or 0.9% NaCl solution, slow intravenous infusion Dosage for adults 2.5 to 10 mcg/kg/min. Dosage for children: 2.5 - 5 mcg/kg/min. Dosage and rate depend on the doctor's prescription, blood pressure, pulse, central venous pressure and hourly diuresis.

4. Undesirable effects of the drug Dobusafe

During the use of Dobusafe, you may experience some unwanted effects, specifically as follows:
Mild increase in blood pressure, increased heart rate, arrhythmia. Nausea, headache, chest pain, shortness of breath. In rare cases, users may experience hypotension, itchy rash, fever, leukocytosis, bronchospasm. Acute asthma, loss of consciousness, and shock can occur in people with asthma. These adverse reactions usually subside upon discontinuation of the drug. Patients need to actively inform the doctor about the unwanted effects encountered when using Dobusafe.

5. Dobusafe drug interactions

During treatment with Dobusafe, users need to be careful when using it in combination with the following drugs:
Do not use with Albuterol, Cimetidine, Furazolidone or Insulin. Do not mix the drug in alkaline solutions, solutions containing Na pyrosulphite. Dobusafe drug interactions may alter its ability to work or increase the effects of unwanted effects. You need to proactively list to your doctor or pharmacist all the prescription and nonprescription drugs, vitamins and minerals, herbal products and wellness foods you are taking to minimize possible drug interactions.

6. Some notes when using Dobusafe

During the use of Dobusafe, patients need to pay attention to the following issues:
6.1. Contraindications of the drug Dobusafe Contraindications of the drug Dobusafe in the following cases:
People with a history of sensitivity or a history of allergy to the main active ingredient Dobutamine or other ingredients contained in the drug. Patients with diseases related to pericardial effusion, coarctation of the aorta, narrowing of the outflow tract of the aorta caused by obstruction of ventricular filling and/or peripheral ejection. People with arrhythmias. People with bronchial asthma. People who are allergic to sulfate. Pregnant women and those who are breastfeeding. Contraindications here should be understood as absolute contraindications, that is, not for any reason that contraindications can be flexible in the use of the drug.
6.2. Precautions while using Dobusafe Breast-feeding women should not take Dobusafe because there are not many specific studies to ensure safety for mothers and nursing infants.
6.3. How to store Dobusafe medicine Store Dobusafe medicine at a temperature below 25°C, avoiding direct sunlight. Keep medication out of reach of children to prevent accidental ingestion. Above is all information about Dobusafe, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Dobusafe medicine to treat diseases at home, because there may be unwanted side effects to health.
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