This is an automatically translated article.
Miconazole is an active ingredient with an effective antifungal effect. This active ingredient is prepared in many different forms with many different trade names, one of which is Daktarin Oral Gel 10g. So what does Daktarin Oral Gel 10g do?
1. What is Daktarin Oral Gel 10g?
Daktarin Oral Gel 10g is a product of Janssen Company - Cilag Ltd., (Thailand), the main ingredient is Miconazole 20mg.
Daktarin Oral Gel 10g is in the form of oral gel, white in color and has an orange taste, packing specification for each box is 01 tube containing 10g gel.
3. What is the effect of Daktarin Oral Gel 10g?
Miconazole in Daktarin Oral Gel 10g has antifungal activity against both ringworm and yeast. The activity of Daktarin Oral Gel 10g is based on the fact that Miconazole inhibits ergosterol biosynthesis in fungi, thereby changing the lipid composition of cell membranes and eventually leading to necrosis of fungal cells.
4. Indications and contraindications of Daktarin Oral Gel 10g
Daktarin Oral Gel 10g is indicated in the treatment of Candida infections in the oral cavity, pharynx and gastrointestinal tract. Daktarin Oral Gel 10g product is for use only in adults and children 4 months of age and older.
Contraindications to using Daktarin Oral Gel 10g:
People with hypersensitivity to the active ingredient Miconazole, other imidazole derivatives or any excipients contained in the Daktarin Oral Gel 10g tube; Children under 4 months old; The child has not yet fully developed the swallowing reflex; Patients with liver dysfunction ; Daktarin Oral Gel 10g is contraindicated for use in combination with active substances metabolized by the CYP3A4 enzyme system, including: drugs known to prolong the QT interval (such as Astemizol, Cisaprid, Dofetilide, Mizolastine, Pimozide, Quinidine, Sertindole and Terfenadin), oral HMG-CoA reductase inhibitors (such as Simvastatin, Lovastatin...), oral Triazolam and Midazolam.
5. Instructions for using Daktarin Oral Gel 10g
How to use Daktarin Oral Gel 10g :
This product is produced for oral use after meals; One measuring spoon is equivalent to 124mg of Miconazole equivalent to 5ml of Daktarin Oral Gel 10g; When used for children, each dose of Daktarin Oral Gel 10g should be divided into small pieces, then use a clean finger to rub the fungal lesions. Daktarin Oral Gel 10g should not be inserted into the back of the throat of young children because of the potential for suffocation, and encourage children to keep the medicine in their mouth for as long as possible (the gel should not be swallowed immediately); Children 2 years of age and older and adults should take Daktarin Oral Gel 10g after meals, similarly should keep the gel in the mouth for as long as possible. Specific dosage of Daktarin Oral Gel 10g for oral and pharyngeal candidiasis:
Children 4 - 24 months old: 1.25ml Daktarin Oral Gel 10g (equivalent to 1⁄4 measuring spoon) each time, 4 times/day; Adults and children 2 years of age and older: 2.5ml of Daktarin Oral Gel 10g (equivalent to 1⁄2 measuring spoons) each time, 4 times a day; The duration of taking Daktarin Oral Gel 10g should be maintained for at least a week after the symptoms of fungal infection disappear; Oral candidiasis cases and dentures should be removed at night and scrubbed with gel.
6. Side effects of Daktarin Oral Gel 10g
Digestive disorders such as dry mouth, mouth discomfort, nausea, vomiting; Abnormal taste at the application site; Taste disorder; Anaphylactic reactions, hypersensitivity; Suffocate; Diarrhea, stomatitis, tongue discoloration; Angioedema, toxic epidermal necrolysis, Stevens-Johnson syndrome, urticaria, rash, acute generalized pustular rash, eosinophilia. When experiencing side effects of Daktarin Oral Gel 10g, patients should stop using and notify their doctor or go to the nearest hospital for timely diagnosis and treatment.
7. Precautions when using Daktarin Oral Gel 10g
If concurrent use of Daktarin Oral Gel 10g and an anticoagulant is planned, close monitoring and monitoring of anticoagulant effect should be performed to adjust the dose as soon as necessary.
Serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported in association with Daktarin Oral Gel 10g and other dosage forms of the active ingredient Miconazole. If this occurs, the patient should not continue treatment with Daktarin Oral Gel 10g.
Doctors need to closely monitor the concentration of Miconazole and Phenytoin when using 2 drugs at the same time.
Patients being treated for diabetes with certain oral agents (such as sulfonylureas) may experience excessive hypoglycaemia that occurs during concomitant treatment with Daktarin Oral Gel 10g, therefore consideration should be given to the following: appropriate remedial measures.
Choking in children, especially in infants and young children (over 4 years old due to the risk of Daktarin gel blocking the throat. Therefore, Daktarin Oral Gel 10g should not be used on the back wall of the throat and at the same time. each dose should be divided into several smaller parts to open the mouth with a clean finger. Family members need to monitor the patient because choking can happen at any time. Also because of this risk, absolutely do not apply Daktarin. Oral Gel 10g into the nipples of nursing mothers An important requirement when using Daktarin Oral Gel 10g is to ensure swallowing function in fully developed infants (4-6 months old) Improvement
Daktarin Oral Gel 10g contains a small amount of ethanol (alcohol) in its composition, but the content is less than 100mg per dose.
Serious skin reactions (eg toxic epidermal necrolysis and syndrome) Stevens-Johnson syndrome) has been reported in patients receiving Daktarin Oral Gel 10g, so patients should promptly notify their physician of signs of a skin reaction. serious and the doctor will decide whether the patient should continue taking the medicine.
Daktarin Oral Gel 10g does not affect the ability to drive and use machines.
Avoid using Daktarin Oral Gel 10g on pregnant women. Besides, until now it is not known whether Miconazole is excreted in human milk, so caution should be exercised when using Daktarin Oral Gel 10g in this subject.
8. Drug interactions of Daktarin Oral Gel 10g
Miconazole in Daktarin Oral Gel 10g inhibits the metabolism of drugs metabolised by the CYP3A4 and CYP2C9 enzyme systems, thereby increasing and/or prolonging the duration of action of those drugs.
Caution should be exercised when the following drugs are co-administered with Daktarin Oral Gel 10g because of the possible increase or prolongation of the therapeutic and/or adverse effects:
Drugs metabolized by CYP2C9; Oral anticoagulants: Warfarin; Oral hypoglycemic agents of the Sulfonylurea group; Phenytoin; Drugs metabolized by CYP3A4: HIV protease inhibitors such as Saquinavir, anticancer drugs such as Vinca alkaloids, Busulfan and Docetaxel; Immunosuppressants such as Cyclosporin, Tacrolimus, Sirolimus); Carbamazepine, Cilostazol, Disopyramide, Buspirone, Alfentanll, Sildenafil, Alprazolam, Brotizolam, Midazolam IV; Rifabutin, Methylprednisolone, Trimetrexate, Ebastine and Reboxetine.
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