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Companity is used in some diseases of the gastrointestinal tract and liver encephalopathy. So what is Companity? How does it work and how to use it? Please refer to these questions through the following article.
1. What does Companity do?
Companity medicine 670mg/ml has the main ingredient is Lactulose 670mg/ml, 7.5ml oral solution form.
After taking Lactulose, the bacteria in the colon are broken down into low molecular organic acids. These acids reduce the pH in the colonic lumen and by osmosis, lead to an increase in the volume of the contents of the colon. These effects stimulate colonic motility and restore stool firmness. Constipation is excluded and the physiological rhythm of the colon is restored.
In hepatic encephalopathy: Because the absorption of ammonia in the intestine will increase with pH, the pH in the colon decreases under the effect of lactulose accompanied by a decrease in ammonia absorption, the pH in the colon decreases due to lactulose leading to amplification. dispersing ammonia from the blood into the intestines. On the other hand, in an acidic environment, ammonia in the colon (NH3), which can diffuse from the intestines into the blood, will be converted to ammonium salts (NH4), which is non-diffusing, which will interfere with the excretion of ammonia. dispersed into the blood.
The acidification of the environment in the intestines will stimulate increased intestinal motility, which allows faster elimination of ammonia from the body. In this case, however, it was recognized that elevated ammonia alone could not explain the neuropsychiatric manifestations of portal encephalopathy, but nevertheless ammonia could be considered as a known substance. known to be harmful to the body compared to other nitrogenous substances.
Lactulose is a synthetic disaccharide. After oral administration, this substance passes through the upper part of the gastrointestinal tract without being metabolized, not absorbed. In the colon, under the action of glycolytic bacteria, lactulose is converted to organic acids and then excreted in the feces.
2. Indications and contraindications of the drug Companity
Indications of the drug Companity in the following cases:
Treatment of constipation, helping to regulate physiological peristalsis of the colon; Used in cases where the creation of soft stools is beneficial for treatment such as hemorrhoids, after colon/anal surgery. Hepatic encephalopathy: Treatment and prevention of hepatic coma or pre-coma. Do not use in the following cases:
Physical diseases in the inflammatory colon such as ulcerative colitis, Crohn's disease ..., intestinal obstruction or semi-obstruction syndrome, abdominal pain of unknown cause. Allergy to any of the ingredients in the medicine. Diet with galactose component because in the composition of the drug there is a similar sugar.
3. Dosage and how to use Companity
How to use: This medicine is taken orally or rectally. Can be taken whole or diluted with beverages.
Dosage to treat constipation:
Infants from 0 to 12 months: Use 1 tube of Companity (7.5ml)/day. Children from 1 to 6 years old: Use 1 to 2 ampoules/day. Children from 7 to 14 years old: Attack treatment uses 2 ampoules / day, maintenance treatment uses 1 tube / day. Adults: Treat with a dose of 2 to 5 ampoules/day, or 10 to 25 g/day. Maintenance treatment is 1 to 2 ampoules/day. Note that if you have diarrhea, you need to reduce the dose.
Hepatic encephalopathy:
The starting dose is 30-45ml (4-6 ampoules)/one time using vga 3-4 times a day. Then adjust the dose to the maintenance dose to be able to have soft stools 2-3 times a day. May be administered via nasogastric tube if the patient is not awake or douche. The duration of treatment varies according to the symptoms of the disease. The elderly and people with impaired liver and kidney function: No dose adjustment is required in the elderly and patients with impaired liver and kidney function.
4. Side effects of the drug Companity
Some possible side effects such as:
Distention and loose stools: These disorders may occur at the beginning of treatment, these phenomena will disappear when the appropriate dose adjustment. Rarely, manifestations such as pruritus, anal pain, and moderate weight loss have been observed.
5. Pay attention when taking the drug Companity
You should not treat constipation with long-term medication. Taking medicine to treat constipation is only an adjunct to the treatment with hygiene and diet, so it should be combined with a suitable diet when taking the drug:
Eat foods rich in fiber and drink a lot country. Increase exercise if possible and should practice bowel habits. In infants and young children, laxatives should be prescribed only when absolutely necessary, because the use of Companity has the risk of disrupting the normal defecation reflex in the child.
The usual dose used in the treatment of patients with constipation has no effect on patients with diabetes. Therefore, it can be used as a solution for diabetics.
When the drug is not effective or relapses after stopping treatment, you must see a doctor for other treatment.
If administered to patients with lactose intolerance, the dosage of lactose should be considered.
Drug Interactions: Due to lactulose's pH-lowering effect in the colon, drugs that depend on colon pH for release may be inactivated.
Store the medicine in a sealed tube, when opened, it should be used immediately.
Hopefully, the above information can help you understand about the drug Companity. You need to carefully read the instructions for use, consult your doctor / pharmacist before using to ensure safety for health.
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