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Boceprevir belongs to the group of antiviral drugs, used in the treatment of chronic hepatitis C - an inflammation of the liver caused by the hepatitis C virus (HCV). Let's learn about the use of Boceprevir through the article below.1. What is Boceprevir?
Boceprevir is a drug for the treatment of chronic hepatitis C virus, prepared in the form of a capsule, with the main ingredient being Boceprevir with a strength of 200mg and other excipients sufficient.2. Uses of Boceprevir
Boceprevir is used in the following cases:
In combination with Peginterferon alfa and Ribavirin in the treatment of chronic hepatitis C genotype 1 infection in adults. People with compensated liver disease, including cirrhosis, who have not or have been treated with interferon and ribavirin but have not responded to treatment, have partial response, or have relapsed.
3. Dosage - how to use Boceprevir
Dosage:
In adults: Take 800mg x 3 times/day with food
After starting treatment with Peginterferon and Ribavirin for 4 weeks, will add Boceprevir, duration of treatment depends on response viral suppression and the patient's condition.
For people with liver and kidney failure, no dose adjustment is required.
How to use:
Do not use Boceprevir alone to treat hepatitis C but must be combined with Peginterferon alfa and Ribavirin. Should be taken with food (in the main or side meal) to promote the therapeutic effect of the drug. If you forget to take a dose, if it is less than 2 hours after the next dose, skip the missed dose, if it is more than 2 hours after the next dose, you can take the next dose with food and continue taking the medicine as usual. . Should be used according to the recommended dose, do not increase or decrease the dose on your own.
4. Contraindications of Boceprevir
Boceprevir should not be used in the following cases:
People with a history of hypersensitivity to any of the ingredients contained in the drug People with autoimmune hepatitis When taking Boceprevir with Ribavirin concurrently, it can cause teratogenicity or death for the patient. fetus, so the drug is not used for pregnant women and men whose partners are pregnant women.
5. Interactions with Boceprevir
When co-administered with strong inducers of CYP3A4/5 can significantly reduce blood concentrations of Boceprevir, resulting in decreased therapeutic efficacy. In addition, the drug also interacts with some drugs such as Atorvastatin, Mometasone. Ciclosporin, Axitinib...
6. Boceprevir side effects
When using Boceprevir can cause some of the following side effects:
Fatigue, insomnia, headache Anemia, dizziness, dizziness, difficulty breathing, hair loss Changes in appetite, loss of appetite, nausea, vomiting, diarrhea, weight loss Fever, rash, chills Joint pain Agranulocytosis, thrombocytopenia During the use of the drug, if the patient shows any serious abnormal symptoms, contact immediately with the treating doctor or medical staff for timely guidance and treatment.
7. Notes and cautions during the use of Boceprevir
Women should be tested before starting treatment with Boceprevir to make sure they are not pregnant.
Do not become pregnant within 6 months after finishing the course of treatment.
There are no data on whether Boceprevir is excreted in human milk, so its use in lactating women is not recommended.
Safety and effectiveness of treatment in children under 18 years of age have not been established.
Safety and efficacy have not been established in patients with decompensated cirrhosis, organ transplant, or HBV or HIV co-infection.
Compared with treatment regimens with Peginterferon alfa and Ribavirin alone, the addition of Boceprevir to the treatment regimen can reduce blood hemoglobin levels, causing anemia, along with an increased risk of causing decreased blood counts. neutrophils in patients.
There were no significant differences in the pharmacokinetics of the drug when administered to healthy subjects and to subjects with impaired hepatic and renal function, so no dose adjustment was required in these subjects.
The drug can cause fatigue, dizziness, headache, blurred vision, so caution should be exercised when driving, operating machinery or working in potentially hazardous conditions.
Above is some information about Boceprevir, if you need advice or have any questions, please contact a qualified doctor or pharmacist for answers.
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