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Bio Panto pills are manufactured by Biodeal Laboratories Pvt. Ltd, the drug is circulated in Vietnam with registration number VN-12192-11 and is prepared in the form of enteric coated tablets. So what is Bio Panto?
1. What is Bio Panto?
Bio Panto is a medicine with the ingredient Pantoprazole Sodium Sesquihydrate, content 40mg. Pantoprazole is a proton pump inhibitor drug. This active ingredient has the effect of inhibiting the last stage in the process of acid formation in the stomach. This mechanism leads to inhibition of both normal gastric acid secretion and gastric acid secretion in the presence of stimulants. Pantoprazole showed an anti-acid effect lasting more than 24 hours at all doses tested.
2. What are the uses of Bio Panto?
Bio Panto drug has a specific and irreversible inhibitory effect on the proton pump, due to its selective effect on the stomach cell wall, the drug works faster and more effectively than drugs acting on the gastrointestinal tract. other. When using Bio Panto, the healing rate, also known as the ability to heal ulcers, can reach 95% after 8 weeks of treatment. The drug has little effect on gastric juice volume, pepsin secretion, gastric endogenous factor and normal gastric contraction of the body, so Bio Panto is indicated for use in the following cases:
Peptic ulcer ; Gastroesophageal reflux disease (GERD); Combined with 2 suitable antibiotics to kill Helicobacter pylori in peptic ulcer patients, Bio Panto helps heal ulcers and prevent recurrence; Prevention of gastric ulcers caused by side effects of non-steroidal anti-inflammatory drugs; Zollinger-Ellison syndrome.
3. Contraindications of Bio Panto
The following patients should not take Bio Panto: patients with a history of hypersensitivity to pantoprazole or to any component of the drug or other benzimidazole derivatives (esomeprazole, lansoprazole, omeprazole, rabeprazole).Clinical experience with pantoprazole in pregnancy is very limited, and there is currently no information on whether pantoprazole passes into breast milk, so Pantoprazole should only be used when the benefit to the mother outweighs the risk to the mother. with fetus and baby.
4. Dosage and how to use Bio Panto
Dosage:
Dosage of Bio Panto in gastroesophageal reflux syndrome (GERD): Bio Panto usual dose: 20-40 mg x 1 time / day, used for 4 weeks or maybe lasts up to 8 weeks; Bio Panto maintenance dose: 20-40 mg per day; In case of recurrent gastroesophageal reflux disease: 20mg/day. Dosage of Bio Panto in peptic ulcer disease: Bio Panto usual dose: 40 mg x 1 time/day. Duration of treatment can be extended from 2-4 weeks for duodenal ulcers or up to 4-8 weeks for benign gastric ulcers. Bio Panto drug dose used in Helicobacter pylori eradication regimen: Use a triple combination therapy regimen: Pantoprazol 40mg x 2 times/day in combination with antibiotic clarithromycin 500mg x 2 times/day and antibiotic Amoxicillin 1g x 2 times/day or antibiotic Metronidazol 400mg x 2 times/day, treatment for 7 days. Prevention of ulcers caused by non-steroidal anti-inflammatory drugs using pantoprazol 20mg/day. Zollinger - Ellison syndrome: Bio Panto starting dose: 80mg/day, Bio Panto can be used up to 240mg/day. If taking more than 80 mg/day, the patient should be divided into 2 oral doses. Patients with hepatic impairment: The maximum dose used is 20mg/day or 4mg/day for patients taking the dose every other day. Patients with renal failure: Maximum dose of Bio Panto: 40 mg/day. How to use:
Bio Panto is usually taken once a day in the morning, swallow whole, do not crush or chew Bio Panto. In combination therapy against Helicobacter pylori, the 2nd Bio Panto tablet should be taken before dinner. If you forget to take Bio Panto on time, do not take the make-up dose later in the day, but just continue taking your normal dose the next morning in the course. Combination therapy requires only 7 days of treatment to eradicate Helicobacter pylori and heal ulcers.
5. Drug Interactions of Bio Panto
When taking Bio Panto with drugs with pH dependent absorption of the stomach such as Ampicillin, iron salts, Ketoconazole ... may increase or decrease the absorption of these drugs because Bio Panto increases gastric pH. There is a potential for increased INR and prothrombin time when Warfarin is co-administered with proton pump inhibitors, including Bio Panto, thereby increasing the risk of abnormal bleeding and death. Therefore, it is necessary to monitor the evolution of the INR and prothrombin time when Pantoprazol is co-administered with Warfarin. Sucralfate can slow absorption and reduce bioavailability of Bio Panto and proton pump inhibitors (eg lansoprazole, omeprazole) so proton pump inhibitors should be taken at least 30 minutes before taking Sucralfate.
6. Side effects of Bio Panto
In general, pantoprazole is well tolerated even with short-term and long-term treatment. Proton pump inhibitors such as Bio Panto decrease the acidity of the stomach (increasing the pH), thus increasing the risk of gastrointestinal infections. Other common side effects when using Bio Panto:
Fatigue, headache; Skin rash, urticaria; Muscle pain, joint pain. Rare side effects of Bio Panto:
Body weakness, dizziness, dizziness. Itchy; Increase liver enzymes. Rare side effects of the drug Bio Panto
Sweating, peripheral edema, anaphylactic reactions; Skin maculopapular rash, acne, alopecia, exfoliative dermatitis, erythema multiforme; Stomatitis, belching, digestive system disorders; Blurred vision, fear of light; Insomnia, somnolence, agitation or inhibition, tinnitus, tremor, hallucinations, paresthesias; Eosinophilia, granulocytopenia, decreased platelet count; Impotence ; Hematuria, interstitial nephritis; Hepatitis, jaundice, hepatic encephalopathy, increased triglyceride index; Hyponatremia.
7. Precautions when using Bio Panto
Long-term treatment: Use of proton pump inhibitors such as Bio Panto, especially at high doses and for longer than 1 year, may slightly increase the risk of hip, wrist and bone fractures. living. This condition mainly occurs in the elderly or those with other risk factors. Observational studies have also shown that proton pump inhibitors have the potential to increase the risk of fractures by 10 to 40%. Severe hypomagnesaemia has been reported in patients treated with proton pump inhibitors for at least 3 months, in most cases for about 1 year. Symptoms of severe hypomagnesaemia include: fatigue, muscle spasticity, delirium, dizziness, and ventricular arrhythmias. This condition may improve after magnesium supplementation and discontinuation of Bio Panto. Symptomatic response to treatment with Bio Panto did not prevent the progression of tumors inside the stomach. Therefore, it is necessary to exclude the possibility of malignant peptic ulcer before taking Bio Panto because Pantoprazol can mask symptoms, leading to late detection; Mild and transient increases in serum ALT have been reported during treatment with the active ingredient oral pantoprazole; Bio Panto may lead to malabsorption of Cyanocobalamin; The safety and effectiveness of Bio Panto in children under 18 years of age have not been established; Bio Panto can cause dizziness and visual disturbances, so patients should not drive or use machines if these side effects occur while taking this medicine.
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