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Berodual 10ml is a combination drug used to relax tracheobronchial smooth muscle. The drug is prepared in the form of a metered dose spray, used in diseases with bronchial smooth muscle spasm such as bronchial asthma, COPD.
1. Uses of Berodual 10ml
In the spray Berodual contains two main ingredients including Fenoterol and Ipratropium. In addition to the 10ml Berodual spray bottle, there is also the 20ml Berodual type. Both substances have the effect of relaxing bronchial smooth muscle by different mechanisms, so when combined, they will have a synergistic effect.
Substance Ipratropium bromide: Is an anticholinergic agent, antagonizing the action of acetylcholine, a chemical mediator secreted from the vagus nerve. This has the effect of preventing increased intracellular calcium levels, thereby preventing smooth muscle contraction. The bronchodilator effect after inhalation of ipratropium bromide is locally specific and has no systemic effect. For Fenoterol hydrobromide: This is a sympathomimetic agent that acts directly and selectively on beta receptors of the adrenergic system, thereby helping to relax smooth muscle. Fenoterol hydrobromide relaxes bronchial smooth muscle and blood vessels and counteracts bronchoconstrictor agents such as histamine, methacholine, and allergens. In addition, it also has an effect on the beta receptors of the heart causing increased heart rate, increased myocardial contractility. Concomitant use of these two active substances causes bronchodilator because it acts on different sites of bronchial smooth muscle. These two active ingredients complement each other to help relax bronchial muscles and thereby allow a wide therapeutic use in bronchopulmonary diseases associated with airway spasm. Research shows that patients with asthma and COPD, have better results than when taking ipratropium or fenoterol alone at similar doses.
2. Indications and contraindications of the drug Berodual 10ml
2.1. Indications Berodual drug is indicated in the following cases:
In acute bronchospasm such as acute asthma due to Berodual with rapid action. Maintenance and prevention of episodes of dyspnea in diseases such as chronic obstructive pulmonary disease (COPD), emphysema, and bronchopulmonary disorders that cause bronchospasm. Used in the long-term treatment of asthma attacks, helping to reduce the development of acute asthma attacks. 2.2. Contraindications Berodual 10ml is contraindicated in the following cases:
Hypersensitivity to the active ingredients, atropine-like substances or allergy to any of the ingredients. In patients with hypertrophic obstructive cardiomyopathy, tachyarrhythmias. Some cases should be cautious when using Berodual:
People with narrow-angle glaucoma, hyperthyroidism, narrowing of blood vessels, prostatic hyperplasia. Bladder neck obstruction. Hypokalemia.
3. Usage and dosage of Berodual 10ml
3.1. How to use This is a 10ml metered dose of Berodual, so you need to use it exactly as directed, avoid overdosing or underdosing as indicated. The steps to spray are as follows:
If using for the first time, remove the protective cap and press the valve of the spray bottle twice. Or if you don't use it for 3 days, you need to press the spray twice to start the spray valve. Then you exhale as hard as you can. Hold the lip spray around the mouthpiece. The arrow and the bottom of the spray bottle are pointing upwards. Inhale as much as possible, while pressing firmly on the bottom of the inhaler with your hands to release a standard dose. Hold your breath for a few seconds, then remove the mouthpiece from your mouth and exhale. Do the same with a second spray if needed. When finished, close the protective cap after each use. When using, you need to clean the spray bottle once a week by first removing the protective cap and taking the bottle out of the mouthpiece. Rinse the mouthpiece with warm water until no residue is left, and dust is removed. Shake the mouthpiece vigorously after cleaning and allow it to dry naturally without drying. When the mouthpiece is dry, install the spray bottle and dust cap. 3.2. Dosage Dosage will depend on many factors, such as the patient's ability to respond, age... Below is a reference dose for each case included.
Acute asthma: Using 2 sprays is suitable for quick relief of symptoms. In more severe cases, if shortness of breath does not improve after 5 minutes, 2 more sprays can be used. If bronchial asthma does not improve after 4 puffs, one more dose can be given and the patient should seek medical attention at the nearest hospital immediately. Intermittent treatment and prolonged treatment: Use 1-2 sprays for each use, maximum use 8 sprays per day (average is about 1-2 sprays 3 times per day). For children, it is necessary to use the prescribed dose and under the supervision of an adult.
4. Berodual 10ml side effects
When using Berodual 10ml, some unwanted effects may occur including:
The most common side effects include cough, dry mouth, headache, sore throat, nausea, dizziness, trouble breathing , tachycardia, palpitations, increased systolic blood pressure and restlessness, tremor. Hypokalemia, restlessness, anxiety, mental confusion. Glaucoma, accommodation disorder, dilated pupils, eye pain, blurred vision, conjunctival congestion, halo vision. Rarely may cause arrhythmia, atrial fibrillation, myocardial ischemia, supraventricular tachycardia, paradoxical bronchospasm, muscle weakness, myalgia, urinary retention. Hypersensitivity reactions: Causes urticaria, difficulty breathing, facial swelling, tachycardia, possibly coma. When experiencing side effects of the drug, you need to stop using it and notify the treating doctor or go to the nearest medical facility for timely treatment.
5. But be careful when using Berodual 10ml
You need to take the medicine under the doctor's prescription, follow the correct dosing regimen and avoid overdose. Before use, inform your doctor about your medical history, history of drug or food allergies. When using the drug can cause an overdose if used incorrectly, sprayed too many times. Overdose effects are mainly related to fenoterol. Symptoms encountered in overdose due to excessive beta adrenergic stimulation, mainly tachycardia, palpitations, muscle tremors, increased blood pressure, increased pulse pressure, angina pectoris. Overdose of ipratropium bromide is usually mild (eg, dry mouth, accommodation-related visual disturbances) because the systemic exposure of ipratropium administered by inhalation is very low. In case of overdose or symptoms of overdose, seek medical attention immediately. When taking Berodual drugs, there may be interactions with other drugs, some drugs that affect the respiratory tract interact with this drug, including Salbutamol, Salmeterol, Formoterol, Bambuterol, Oxitropium, Tiotropium...Xanthine derivatives... such as theophyllin and corticosteroids (such as presnisolone, methylprednisolone...). These substances can enhance or limit the effect of the drug, so be sure to consult your doctor when combining. During the use of the drug, it is necessary to absolutely avoid getting the medicine into the eye area. It is necessary to read carefully how to use the medicine, avoid spraying too many times without knowing whether the medicine has entered or not. Especially with young children, it is necessary to observe the children performing, not to let them do it themselves. Clean the mouthpiece regularly to make sure medicine doesn't get stuck in the cap or make it difficult to spray and avoid infection. Use the correct type of mouthpiece provided by the manufacturer, do not substitute the mouthpiece for another medication, and also do not use the Berodual mouthpiece for other medications. Certain foods can also create drug interactions. Please consult your doctor so that you have the most reasonable diet and it is best that you do not use tobacco, stimulants, and alcohol while using the drug. Berodual medicine 10ml is used for bronchodilators to help control acute and chronic asthma attacks, some other cases of bronchospasm. But prescription drugs need a doctor's prescription, you should not self-medicate.
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