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Azithromycin 500mg contains the active ingredient Azithromycin, which is effective against sensitive bacteria. On the market today, there is a lot of information about Aziefti drug products, but it is still incomplete. To better understand what Aziefti 500mg is, how it works, let's learn more in the article below.
1. What is Aziefti 500mg?
Azithromycin 500mg is manufactured by 3/2 Pharmaceutical Joint Stock Company with the main ingredient Azithromycin, which is a drug used to treat infections caused by sensitive bacteria in infections such as upper respiratory tract, skin. , urinary, cervical and male genital tract infections.1.1. Drug form and strength
Aziefti is produced in many different forms and strengths such as:
Powder for oral suspension with content of 100mg and 200mg; 250mg capsules and 500mg film coated tablets.
1.2. Aziefti 500mg includes the following ingredients:
Main ingredients: Active ingredient Azithromycin also works against bacteria that cause inflammatory diseases in the body; Excipients include: Sucrose crystal, trisodium phosphate (dodecahydrate), sodium chloride, sodium CMC, Colloidal Silicon Dioxide (Aerosil 200), Aspartame, propylparaben, methyl paraben, Cream-de-Vanilla flavour, Artificial Cherry Flavor, Veltol and FD&C Red No.40. 1.3. Pharmacodynamics of Azithromycin 500mg Azithromycin is sensitive to typical bacteria, such as:
Gram-positive aerobic bacteria such as: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes; Gram-negative aerobic bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila, Moraxella catarrhalis and Pasteurella multocida; Anaerobic bacteria: Clostridium perfringens, Fusobacterium spp., Prevotella spp and Porphyromonas spp. Other bacteria: Chlamydia trachomatis.
Macrolid prevents bacterial growth by inhibiting protein synthesis and translation, treating bacterial infections. Azithromycin also has an additional immunomodulatory effect and has been used in chronic inflammatory diseases of the respiratory tract for this purpose.
1.4. Pharmacokinetics of Azithromycin 500mg Absorption: Azithromycin is rapidly absorbed and oral bioavailability is approximately 40%. In particular, the drug achieves higher concentrations in cells than in plasma, so it is good to treat intracellular bacteria. Food reduces drug absorption and oral bioavailability by about 40%; Distribution: Widely distributed throughout the body and mainly into tissues such as lungs, tonsils, prostate, granulocytes and macrophages..., many times higher than in blood and however systemic drug concentrations very low central nervous system; Metabolism: A small amount of azithromycin is demethylated in your liver, and is excreted in the bile in unchanged form and partly as unchanged drug; Elimination: Approximately 6% of an oral dose is excreted in the urine within 72 hours as unchanged.
2. What are the uses of Aziefti?
Aziefti 500mg is indicated for the treatment of infections caused by susceptible bacteria in the following cases:
Treatment of respiratory tract infections with: Exacerbation of infection in obstructive pneumonia caused by Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae; infectious pneumonia caused by Chlamydia pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Streptococcus pneumoniae; pharyngitis and tonsillitis caused by Streptococcus pyogenes in patients unable to receive group 1 antibiotics. Treatment of skin infections caused by Staphylococcus aureus, Streptococcus pyogenes or Streptococcus agalactiae. Treatment of urinary tract and cervical infections: Urinary tract infections and cervicitis caused by Chlamydia trachomatis or Neisseria gonorrhoeae. Treatment of male genital tract infections: Chlamydia by Haemophilus ducreyi. 3. Side effects of the drug Aziefti 500mg The drug is well tolerated. Most of the side effects of moderate to mild form were reversible upon discontinuation of treatment. The most common is gastrointestinal disorders (about 10%) with the following symptoms: dyspepsia, flatulence, diarrhea, nausea, abdominal pain, abdominal cramps, vomiting, but usually mild and less common than with erythromycin. Hearing loss is reversible with some patients receiving prolonged high doses of the drug. Rarely in cases of taste disorders, nephritis, vaginitis...; the side effects of Macrolid on nerves such as headache, drowsiness, dizziness, dizziness, fatigue...; skin, such as rash, edema, photosensitivity, peripheral angioedema.... Temporary and transient reductions in neutrophil count in clinical trials but no known relationship related to drug use. Reversible increase in liver transaminases. Some cases of liver abnormalities, such as hepatitis, cholestatic jaundice have been reported. 4. Drug interactions Food will reduce the bioavailability of the drug by up to 50%. Erectile Dysfunction: Azithromycin should not be used concurrently with ergot derivatives due to the risk of ergot poisoning. Antacids: Use only at least 1 hour before or at least 2 hours after taking antacids. Digoxin, Cyclosporin: Because Azithromycin affects the metabolism of Digoxin, Cyclosporin, it is necessary to monitor and adjust the dose (if necessary) when using these drugs simultaneously. Coumarin-type anticoagulants: Warfarin and Azithromycin can be used concurrently, but the patient's anticoagulant time must be monitored. Rifabutin: Decrease in neutrophils when used in combination with Azithromycin. Theophylline: The pharmacokinetics of Azithromycin and Theophyllin have not been observed in combination, but theophylline concentration must be monitored when these two drugs are used in patients. Carbamazepine, Cimetidine, Methylprednisolone: Azithromycin has little effect on the pharmacokinetics of Carbamazepine, cimetidine, and methylprednisolone.
5. How to use Aziefti 500mg effectively?
5.1. How to use Aziefti?
Aziefti is well tolerated. Oral medicine: Dissolve the powder with a little warm water and stir well and drink. Take on an empty stomach and 1 hour before meals or at least 2 hours after meals.
Read carefully the usage information: Indications, contraindications, effects, side effects, dosage, usage... details on the instruction sheet for Azifti drug.
5.2. Dosage of the drug Aziefti Adults:
Upper and lower respiratory tract infections, skin and soft tissue infections: The first day you take a single dose of 500 mg, the next 4 days take a single dose of 250 mg / day. Sexually transmitted disease caused by infection with Chlamydia trachomatis, Haemophilus ducreyi or Neisseria gonorrhoeae: 1 gram single dose. The elderly, patients with renal or mild hepatic impairment do not need to adjust the dose. Children under 12 years:
Single daily dose: 10 mg/kg/day for 3 days. Or the first day 10 mg/kg/time/day and the next 4 days 5 mg/kg/time/day. There is no information on the efficacy and safety of Azithromycin for use in infants younger than 6 months of age. Therefore, the drug should not be used in children in this age group.
5.3. Overdose and Management Side effects at doses higher than recommended are similar to those at usual doses. Typical symptoms of an overdose of Macrolide antibiotics will include reversible deafness, nausea, vomiting, and diarrhea. If overdose, appoint activated charcoal and treat symptomatically, apply supportive measures.
6. Be careful when using Azifti 500mg In the process of using the drug, it is necessary to observe signs of superinfection by bacteria that are not sensitive to the drug, including fungi.
For patients with liver failure is because the drug is eliminated mainly by the liver.
6.1. Effects of the drug on driving and operating machinery Caution should be exercised when using the drug in subjects driving and operating machines.
6.2. Use in pregnancy and lactation Pregnancy:
Animal reproduction studies have shown that azithromycin crosses the placenta, but no harmful effects are expected. with the fetus. There are no data on the use of the drug in pregnant women.
Because animal reproduction studies have not always been consistent in humans, azithromycin should not be used during pregnancy, unless an alternative drug is not available.
Lactation period:
Do not use for pregnant and lactating women unless absolutely necessary.
7. How to store the medicine You should store the medicine at room temperature, in a cool, dry place, avoiding direct sunlight. You should not store the medicine in the refrigerator. Keep the medicine out of the reach of children. Do not throw medicine down the toilet or plumbing.
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