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Azaroin gel containing the main ingredient is Clindamycin phosphate, indicated in the treatment of mild to moderate acne, especially in case of inflammatory lesions. Let's learn about the uses and notes when using Azaroin through the article below.
1. Uses of Azaroin
1.1. Indications Azorroin gel containing the active ingredient Clindamycin phosphate is indicated in the treatment of mild to moderate acne, especially in cases of inflammatory lesions.
1.2. Pharmacokinetics The active ingredient Clindamycin phosphate has no effect in vitro, however, it rapidly hydrolyzes in vitro to clindamycin, which has anti-infective activity. The drug inhibits bacterial protein synthesis at the ribosomal level through binding to the 50S ribosomal subunit, thereby affecting the initiation of the peptide chain. In vitro studies have shown that clindamycin is effective against all numbers of Propionibacterium acnes bacteria at a minimum inhibitory concentration (MIC) of about 0.4 g/ml.
1.3. Pharmacokinetics A study performed on 24 acne patients treated with clindamycin 1%, applied about 3-12 g/day as clindamycin gel at a frequency of 1 time/day for 5 consecutive days showed a The peak plasma concentration of the drug is less than 5.5 ng/ml. After repeated application of Clindamycin gel, the amount of drug excreted in the urine was 0.04% less than the dose.
2. Dosage
Acne medication Azaroin gel belongs to the group of drugs for external use, applied to the acne skin as prescribed by the treating doctor. Patients should not arbitrarily use the drug without a doctor's prescription, all information about dosage below is only a recommendation. The recommended dosage of Azaroin is as follows:
Adults and adolescents: Apply 1-2 times daily in the morning or evening. Wash and dry the acne-affected skin before applying the medicine, massage gently to help the medicine penetrate and absorb better; Children: There are no studies demonstrating the safety and effectiveness of clindamycin gel in children under 12 years of age, because acne rarely occurs at this age; Elderly: There are no special recommendations for treatment with Azaroin gel in the elderly. However, it should be noted that the drug should not be used continuously for more than 12 weeks of treatment.
3. Azaroin side effects
Acne medicine Azaroin can cause some side effects as follows:
Common: Dry skin, diarrhea with bloody stools, diarrhea, colitis. Other side effects: Irritation (exfoliation, erythema, burning sensation), contact dermatitis, gram-negative folliculitis, oily skin. Systemic effects: Gastrointestinal disorders, abdominal pain. In case of experiencing side effects, the patient should stop using the drug and immediately notify the treating doctor for timely treatment.
4. Note when using the drug Azaroin
4.1. Contraindications Azaroin gel is contraindicated in patients who are allergic to licomycin, clindamycin or any component of Azoroin.
4.2. Precautions for use Do not let the medicine come into contact with the mouth, eyes and mucous membranes that are scratched or have eczema. Use caution when applying the drug to sensitive areas. In case of accidental contact with the eyes, the patient should immediately rinse with plenty of water.
Clindamycin gel should be used with caution in patients with a history of regional enteritis, ulcerative colitis or antibiotic-associated colitis. It should also be used with caution in patients with atopic dermatitis, as it can make the skin drier.
In case skin irritation or dryness occurs, the frequency of application should be gradually reduced. Clindamycin, like other antibiotics, can cause severe diarrhea and pseudomembranous colitis. Although the incidence of these effects in the external form of the drug is rare, if a patient develops colitis or diarrhea occurs during the treatment period, the drug should be discontinued and the treating physician informed.
Minimize the possibility of exposure to the sun, artificial light during drug treatment.
Pregnant women, lactating women: Azaroin is not recommended for these subjects.
5. Drug interactions
Avoid concurrent use of clindamycin gel with topical acne preparations containing vitamin A derivatives.
Use caution when concurrent use of topical antibiotics with corrosive soaps or detergents, preparations containing high alcohol content, cosmetics with strong drying properties, or astringents as this may occur. synergistic stimulant effects.
Above are all important notes when using Azaroin gel. Knowing the information about the drug and dosage will bring better treatment effect.
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