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Ampito is indicated for the treatment of severe or moderate local or systemic infections. So how is Ampito used?
1. What is Ampito?
Ampito medicine contains ingredients Piperacillin content of 4g, Tazobactam content of 0.5g and excipients just enough provided by the manufacturer. The drug is prepared in the form of powder for injection, packing specification is 1 vial of 4.5g.
2. What does Ampito do?
What does Ampito do? Ampito is indicated for the treatment of moderate or severe local and systemic infections caused by detected or suspected susceptible organisms. The drug is indicated to treat the following specific cases:
Adults, children over 12 years old:
Nosocomial pneumonia. Complicated urinary tract infections. Abdominal infection. Infections of the skin and skin tissues. Infection in children with leukopenia. Children 2-12 years of age:
Infection in pediatric patients with leukopenia. Besides the effects of Ampito, there are some contraindications to using this drug for patients as follows:
Allergy to active ingredients or other excipients in the composition of the drug. Allergy to any beta-lactam drug (including penicillins and cephalosporins) or beta-lactamase inhibitors. Children under 2 months old.
3. Dosage and how to use Ampito
3.1. Dosage The following is the recommended dose of Ampito:
In case of normal kidney function:
Adults, children over 12 years old:
The recommended dose is 1 vial of 4.5g every 8 hours. In case of serious, life-threatening infections, the daily dose is not less than 4 vials and the interval between doses is 4-6 hours. The maximum dose is 6 vials. For patients with fever and neutropenia, it is necessary to treat with empiric broad-spectrum antibiotics against Gram-negative bacilli and Pseudomonas aeruginosa (blue pus bacillus): 1 vial of 4.5 g. once every 6 hours, in combination with Gentamicin 4-5mg/kg/day, used once or divided into 2 times every 12 hours. Prevention of infection in surgery: use 1⁄2 vials immediately before surgery, then every 6 or 8 hours use 1⁄2 vials for 24 hours of surgery. Children from 2 to 12 years old: dose from 200-300 mg/kg/day, divided dose 4-6 hours apart.
Elderly people (over 65 years old): use the same dose as adults, reduce the dose if there is renal failure.
Patients with renal impairment: based on the degree of renal failure to adjust the dose. Specific dosages are as follows:
Adults and children over 50 kg:
Creatinine clearance is 41 - 80ml/min, use 1 vial 4.5g every 8 hours. Creatinine clearance is 21-40ml/min, administered at a dose of 1 vial of 4.5g every 12 hours. Creatinine clearance less than 20ml/min, dose 1 vial 4.5g every 24 hours. For hemodialysis patients: Maximum dose of 2 vials, each vial every 8 hours. In patients with renal and hepatic impairment, plasma concentrations should be measured, then the dose of Ampito should be adjusted. Children under 50kg:
Creatinine clearance is 40-80ml/min, dose 90mg/kg (80mg Piperacillin + 10mg Tazobactam) administered every 6 hours. Creatinine clearance is 20-40ml/min, 90mg/kg dose (80mg Piperacillin + 10mg Tazobactam) administered every 8 hours. Creatinine clearance is less than 20ml/min, 90mg/kg (80mg Piperacillin + 10mg Tazobactam) administered every 12 hours. For patients on dialysis: 45mg/kg (40mg Piperacillin + 5mg Tazobactam) administered every 8 hours. Duration of treatment: In case of acute infection, Ampito should be continued for at least 48 hours after the fever is gone or the clinical symptoms are resolved.
3.2. How to use Ampito drug is prepared as a powder for injection, administered intravenously or intravenously. How to use the drug as follows:
Intravenous injection: Each vial of 4.5g mixed with 20ml of sterile water for injection or mixed with 0.9% sodium chloride solution, injected slowly intravenously for 5 minutes. Intravenous infusion: Each vial 4.5g mixed with 20ml sterile water for injection or mixed with 0.9% sodium chloride solution, then further diluted to at least 50ml with compatible solvents such as: Sodium chloride 0.9%, 5% dextrose, 0.9% sodium chloride and 5% dextrose, intravenous infusion over 20-30 minutes. Some notes when using Ampito:
Do not mix Ampito with other drugs in the same syringe or the same bottle of infusion, because the compatibility has not been determined. Do not use Ampito drug concurrently with other drugs, must be injected at different sites or at different times. Due to chemical instability, do not mix Ampito with Sodium Bicarbonate solution. Ampito should not be added to blood products or albumin hydrolysis products. The solution after reconstitution can be stable for 12 hours at room temperature and 24 hours if stored in the refrigerator at a temperature of 2-8 degrees Celsius. The above dosage is only a recommended dose, the treating doctor will Dosage should be based on the specific condition of each patient.
4. Side effects of the drug Ampito
Before prescribing, doctors always weigh the benefits of Ampito's effectiveness against the possible risks to the patient while taking the drug. However, some cases when using Ampito may still occur undesirable effects such as allergic skin rash, fever, leukocytosis, thrombophlebitis, nausea, diarrhea, increased transaminases, etc. recuperate.
In the course of taking the drug, when the patient encounters the above undesirable effects or any symptoms, immediately notify the doctor for advice and appropriate intervention.
5. Ampito drug interactions
In order to avoid interactions that occur when combining different drugs, the patient should tell the doctor about the drugs you are using such as prescription drugs, over-the-counter drugs, functional foods, herbs. ..
The following are some drugs that have the potential to interact with Amikacina when used in combination as follows:
Caution should be taken when using Ampito and Vecuronium or neuromuscular blocking agents, because there is a risk of reduction. methotrexate excretion. Coagulation parameters should be monitored when co-administered with high-dose heparin, oral anticoagulants or drugs that affect the coagulation system and/or platelet function. Concomitant administration of Probenecid prolongs the half-life and reduces the renal clearance of Ampito. This drug should not be mixed with other antibiotics, especially with Aminoglycosides in intravenous solution or concurrent use, which can cause significant inactivation of Aminoglycosides.
6. Some notes when using Ampito
Here are some notes when taking Ampito to help achieve its effectiveness as well as reduce the risk of side effects:
Before starting treatment with the drug, carefully investigate the patient's allergy history illness with Cephalosporins, Penicillins or other drugs. Use with caution in patients with infectious mononucleosis and renal insufficiency. In case of severe persistent diarrhea, think of antibiotic-associated pseudomembranous enterocolitis, which can be treated with metronidazole. When taking high doses of Ampito, it is necessary to pay attention to the amount of sodium in patients with sodium and water accumulation. Blood function should be checked periodically when taking the drug, because there is a risk of leukopenia and neutropenia with prolonged use of Ampito. It is advisable to periodically evaluate the function of organs such as kidneys and liver during treatment. Some patients with renal failure have signs of bleeding, abnormalities in coagulation tests such as clot formation time, platelet aggregation, and prothrombin time. The drug should be discontinued and appropriate treatment instituted. When using Ampito, there is also a risk of developing drug-resistant bacteria and can cause superinfection, especially during long-term treatment. Do not use the drug in pregnant and lactating women, unless specifically directed by a doctor if the benefits of taking the drug outweigh the possible risks to the fetus and nursing infant. . Above is the important information of Ampito drug, patients need to strictly follow the doctor's instructions to help achieve effective and safe use of the drug.
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