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Amlibon 10mg drug is an antihypertensive drug, used to treat hypertension, angina pectoris and is used to support the treatment of heart failure. Let's find out information about Amlibon 10mg drug through the article below.
1. What are the effects of Amlibon 10mg?
What does Amlibon 10mg do? Amlibon 10mg tablet contains Amlodipine as the main ingredient. The drug is in the form of tablets. Amlodipine is a calcium channel blocker, a dihydropyridine derivative with calcium antagonist activity in smooth muscle cells. When administered, it binds to the N site on the calcium ion transporter channel, reducing the amount of calcium ions entering the cell. Thereby, reducing the spasm of smooth muscle, reducing the resistance of the vessel wall, so it has an effective antispasmodic effect and lowers blood pressure. The effect of the drug helps to relax the smooth muscle around the peripheral arteries and has a weaker effect on the intracellular calcium concentration channel of the myocardium. Accordingly, the drug does not affect atrioventricular conduction in the heart. In addition, Amlodipine reduces vascular resistance in the kidneys, thus increasing renal blood flow and helping to improve renal function.
Thanks to the effect on vascular smooth muscle, the drug helps to dilate blood vessels and is indicated in the following cases:
Treatment of hypertension: Usually indicated in patients with metabolic complications such as diabetes mellitus. Prophylactic treatment of chest pain in patients with stable angina.
2. Usage and dosage of Amlibon 10mg
How to use: Take the drug orally. The patient should take the tablet whole with a glass of water. Be careful not to break, crush or chew. You can take the medicine at any time, but you need to take it at the same time every day.
Dosage: Depending on the response and tolerability of the patient, different doses are used. You can refer to the dose as follows:
The initial dose when using the drug is usually 5mg / time / day. The dose may be increased up to 10 mg (equivalent to 1 Amlibon tablet) once daily. If the effect of the drug is not effective after 4 weeks of treatment, the dose can be increased or combined with other drugs. How to handle when the patient misses dose, overdose
Missed dose: Take that dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose as scheduled. Do not take a double dose. Overdose: Very rarely, overdose causing toxicity Amlodipine. Common signs include a rapid heartbeat, severe dizziness, and fainting. Treatment is as follows: Monitor cardiovascular function by electrocardiogram and treat cardiovascular symptoms, gastric lavage, take activated charcoal. If necessary, treat with correction of electrolytes. In case of severe hypotension, intravenous infusion of 0.9% sodium chloride solution, using the antihypertensive drug adrenaline. If there is no effect, use Isoprenalin in combination with Amrinon in combination with symptomatic treatment.
3. Contraindications of Amlibon 10mg
Amlibon 10mg should not be used in the following cases:
Patients with heart failure who have not been stabilized. Patients with hypersensitivity to any ingredient of the drug. Pregnant women.
4. Undesirable effects of the drug Amlibon 10mg
Amlibon 10mg medicine when used can cause some unwanted effects, including:
Common effects:
The most common side effects of Amlodipine are mild to moderate ankle edema, This is dose related, about 3% with 5mg/day and about 11% with 10mg/day. headache, dizziness, flushing and hot flashes, fatigue, weakness; Palpitations ; Cramp; dyspnea Digestion: Nausea, vomiting, abdominal pain, dyspepsia. Uncommon side effects:
Circulation: Excessive hypotension, tachycardia, chest pain. Allergies: Rash, pruritus. Muscles, bones: Muscle pain, joint pain. Sleep disorders. Rare side effects:
Extrasystoles, urticaria. Laboratory tests: Increased liver enzymes (Transaminase, Lactate). If during the use of Amlibon 10mg, the patient has any adverse effects, immediately notify a qualified doctor or pharmacist so that appropriate assistance can be received.
5. Note when taking Amlibon 10mg
You need to carefully read the instructions on the drug before taking it, talk to your doctor about any history of drug allergies or other medical history before taking the medicine.
Caution when using:
Some people have diseases such as: Aortic stenosis; Congestive heart failure ; Patients with hepatic impairment should be used with extreme caution when taking Amlibon, as this may aggravate this underlying condition. Pregnancy: Calcium channel blockers may cause suppression of premature uterine contractions, but they have no adverse effect on delivery. Because in experimental animals, calcium channel blockers can cause teratogenicity in the form of bone malformations. Therefore, it is best to avoid taking Amlibon 10mg for pregnant women, especially in the first 3 months of pregnancy. If you are planning to become pregnant, talk to your doctor so that you can switch to a more suitable antihypertensive drug. Nursing Mothers: There are currently no studies to show that Amlodipine accumulates in breast milk. In this case, it is necessary to consult a doctor to be carefully considered before using. Drinking alcohol can lower the blood pressure of the drug and may increase certain side effects of Amlibon.
To maintain a stable blood pressure, you should combine it with changing your diet, eating light meals, reducing eating high-fat foods, and increasing your intake of green vegetables and fruits. Increase exercise and lose weight if overweight or obese.
Drug interactions: When combining other drugs with Amlibon 10mg, drug interactions may occur. Some drugs that cause drug interactions include:
Anesthetics: Increases the antihypertensive effect of Amlodipine, causing the patient to have a more severe drop in blood pressure. Lithium: May cause neurotoxicity, nausea, vomiting and diarrhea. Non-steroidal anti-inflammatory drugs, especially Indomethacin, can reduce the antihypertensive effect of Amlodipine by inhibiting Prostaglandin synthesis, keeping sodium in the blood and body fluids. Drugs with high protein binding such as Coumarin derivatives, Hydantoin,...: Because Amlodipine can also be highly protein bound, a competitive reaction with the drug may cause the concentration of the drugs to bind. with free (unbound) proteins, may increase serum concentrations of these drugs. In addition, to ensure safe and effective medication use, tell your doctor about all prescription and over-the-counter medicines, health foods that you are taking.
Storage: Store Amlibon 10mg in a cool, dry place, away from light, at a temperature of 25 - 30 degrees Celsius. Keep out of reach of children.
Amlibon 10mg drug is an antihypertensive drug, used to treat hypertension, angina pectoris and is used to support the treatment of heart failure. The use of the drug can cause some unwanted side effects. Therefore, patients need to strictly follow the instructions of the doctor, professional pharmacist to improve the effectiveness of treatment, and at the same time avoid unwanted side effects.
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