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Akurit-4 drug has the main ingredients are rifampin, isoniazid, pyrazinamide and ethambutol. The drug is manufactured by Lupine Ltd and prescribed by a doctor, indicated for the treatment of tuberculosis caused by Mycobacterium tuberculosis in adults and children weighing more than 20 kg in the attack phase.
1. What is the effect of Akurit-4 and how is it treated?
Akurit-4 drug is a product of Lupine Ltd. Company. The drug has the main active ingredients: rifampin, isoniazid, pyrazinamide, ethambutol. With the above ingredients and active ingredients, Akurit-4 is prescribed by doctors to treat tuberculosis caused by Mycobacterium tuberculosis in adults and children weighing 20 kg or more in the attack phase.
Akurit-4 drug is prepared in the form of film-coated tablets and packed in a box of 15 blisters x 6 tablets.
2. Usage and dosage of Akurit-4
2.1. The route of administration of the drug Akurit-4 is orally, because the drug is prepared in the form of film-coated tablets. Patients should take the drug on an empty stomach (at least one hour before or two hours after a meal) because bioavailability may be reduced when taken with food. 2.2. Dosage Stage of treatment
Dosage: Dosage of Akurit-4 for children weighing from 21 to 30 kg: 2 tablets x 1 time/day. It should be noted, only for children who are able to swallow whole tablets. Accordingly, the dose of Akurit-4 is calculated according to the patient's body weight:
The dose of Akurit-4 is calculated according to the patient's weight as follows:
30 - 39 kg: The dose of 2 tablets x 1 time / day 40 - 54 kg: Dose of 3 tablets x 1 time / day 55 - 70 kg: Dose of 4 tablets x 1 time / day Over 70 kg: Dose of 5 tablets x 1 time / day Tuberculosis patients who are being treated with Akurit-4 absolutely must not Voluntary cessation of medication or intermittent treatment. If necessary, reduce the dose of active ingredients or discontinue use, the patient must switch to the appropriate drug according to the doctor's instructions.
For patients with renal failure: Patients with renal failure with creatinine clearance ≤ 50 ml/min need to adjust the drug dosage according to renal function. Therefore, manufacturers and physicians often recommend the use of single-active preparations containing ethambutol, isoniazid, pyrazinamide, and rifampin.
For patients with hepatic impairment: The pharmacokinetics of isoniazid and rifampin may be altered in patients with impaired liver function. Therefore, it is necessary to closely monitor for signs of toxicity in patients with hepatic impairment. Accordingly, it should be noted that Akurit-4 is not indicated for patients with acute liver disease.
Children, patients weighing less than 20 kg: Akurit-4 is not suitable for patients weighing less than 20 kg, because the dose cannot be adjusted appropriately.
Elderly people: In this subject, there is no need to adjust the dose of the drug. However, elderly people often have impaired liver and kidney function. Therefore, the addition of pyridoxine (vitamin B6) may be considered during administration.
Treatment interruption
If treatment with Akurit-4 is interrupted during the attack phase, the patient should not continue using this drug but must switch to using single-component preparations active ingredient, as it may be necessary to reduce the dose of the active ingredient rifampin.
Note: The above dosage is for reference only. The specific dose of Akurit-4 depends on the condition and the progression of the disease. To have the right dose of Akurit-4, patients need to consult a doctor, pharmacist for advice.
3. Contraindications to the drug Akurit-4
Contraindicated to use Akurit-4 drug in the following cases:
The patient is sensitive to the ingredients of the drug. The patient has severe liver failure. Pregnant women in the first 3 months. Acute Gout.
4. Side effects of the drug Akurit-4
During the use of Akurit-4, patients may experience some of the following side effects:
Nausea, vomiting. Fever, redness, skin rash Dark urine. Sweat. Yellow skin, yellow eyes. Increase liver enzymes. Increased uric acid levels in the blood. During the use of Akurit-4, patients may experience some other side effects, in addition to the above effects. Therefore, when there are any side effects, the patient should notify the doctor for advice and timely treatment.
5. Akurit – 4 . drug interactions
Akurit - 4 drugs can interact with some of the following drugs:
Atazanavir Cabazitaxel Darunavir Delavirdine Fosamprenavir Lurasidone Dronedarone Etravirine Nifedipine Praziquantel... Accordingly, to avoid drug interactions when using Akurit-4, people Patients should list all medications, including herbal products, herbal medicines, and dietary supplements. ....
6. Note when using the drug Akurit - 4
During the use of Akurit - 4, the patient needs to pay attention to the following and notify the doctor if:
You are allergic to any of the ingredients of the drug. Women who are pregnant or breastfeeding. People with a history of liver disease, kidney disease, hyperuricemia. People taking other medicines There are currently no reports of risks when using Akurit-4 for pregnant women and nursing women. However, to avoid the risks, you should immediately inform your doctor or pharmacist for advice.
7. Treatment of overdose, missed dose of Akurit – 4
Missed dose: If the patient forgets a dose of Akurit-4, it should be added as soon as he remembers. However, if it is almost time for your next dose of Akurit-4, you should skip the missed dose and take your next dose of Akurit-4 at the scheduled time. Absolutely do not use the double dose of Akurit - 4 to make up for it.
Overdose: The use of an overdose of Akurit-4 can cause patients to experience symptoms such as nausea, vomiting, digestive disorders, headache, dizziness, hallucinations, facial edema. It can even cause coma and convulsions. In this case, relatives need to take the patient to the nearest medical facility for examination and treatment. Treatment measures for overdose Akurit-4 include: induce vomiting, gastric lavage and use of activated charcoal. After that, pyridoxine and diazepam can be used to perform intravenous injection and hemodialysis. Currently, there is no specific antidote when using Akurit-4.
Store Akurit-4 in a dry place and avoid direct light. In addition, it should be kept out of reach of children and pets. Do not use the medicine when it has expired or shows signs of deterioration.
In summary, the drug Akurit-4 has the main ingredients are rifampin, isoniazid, pyrazinamide and ethambutol. The drug is manufactured by Lupine Ltd and prescribed by a doctor, indicated for the treatment of tuberculosis caused by Mycobacterium tuberculosis in adults and children weighing more than 20 kg in the attack phase.
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