This is an automatically translated article.
Abmuza drug has ingredients including Rivaroxaban 15mg, which is made in the form of film-coated tablets. The drug belongs to the group of cardiovascular drugs that are effective in the prevention of venous thromboembolism in patients who have undergone major orthopedic surgery of the lower extremities.
1. Mechanism of action of the drug Abmuza
Abmuza drug contains rivaroxaban compound - highly selective inhibitor and factor Xa with gastrointestinal bioavailability. The weak activation of factor X to Xa is through both endogenous and exogenous pathways and plays a central role in the coagulation cascade. The length of time prothrombin is affected will depend on the dose of the drug containing rivaroxaban .
Rivaroxaban when entering the body has the ability to quickly absorb with the maximum concentration after about 2 to 4 hours of taking the drug. Abmuza oral absorption is almost complete and oral bioavailability is relatively high for a dose of 10 mg per tablet accounting for about 80 to 100%. Abmuza 10mg tablets can be taken with or without food.
Drugs with high binding to plasma proteins account for a ratio of about 92 to 95 and are mainly albumin components. Abmuza drug volume when entering the body is distributed at a moderate level.
Approximately 2⁄3 oral doses of Abmuza will be degraded by metabolism and then half of the metabolite will be eliminated by the kidneys and the rest will be excreted in the feces. The rivaroxanban compound in Abmuza is metabolized by CYP3A4, CYP2J2, and by a CYP-independent mechanism. Oxidative and hydrolytic degradation of amide bonds at the major biotransformation site.
2. Indications and contraindications to the use of Abmuza
Abmuza is indicated for the treatment of diseases that have undergone major orthopedic surgery of the lower extremities, and at the same time to help prevent venous thrombosis.
However, the drug is also contraindicated in some specific patients:
Patients with a history of hypersensitivity to all components of the drug Patients with clinically serious bleeding conditions such as such as intracerebral bleeding, gastrointestinal bleeding Patients with liver-related medical conditions and coagulopathy may be at increased clinical risk of bleeding. Although there are no specific data on the safety and effectiveness of Abmuza in pregnant women. However, animal studies have shown that Abmuza can cross the placental barrier. Therefore, do not use Abmuza during pregnancy.
Similarly for nursing mothers, there are no specific data on safety and efficacy. But animal studies suggest that Abmuza can be excreted in human milk. Therefore, Abmuza should only be used when breastfeeding is stopped.
3. Dosage and how to use Abmuza
The recommended dose of Abmuza for the prevention of venous thromboembolism in major orthopedic surgery is one tablet with a strength of 10 mg per day. Duration of treatment with Abmuza: After major hip surgery, patients need to be treated with Abmuza for 5 weeks. And after performing major knee surgery, it is necessary to treat with Abmuza for 2 weeks. Abmuza can be taken with or without food. The initial dose of Abmuza should be administered within 6 to 10 hours after surgery provided that the patient's hemostasis is established and controlled. For patients with mild and moderate renal impairment when using Abmuza, no dose adjustment is required. However, clinical data on the use of Abmuza in this population are still limited. Therefore, it is necessary to be careful and monitor carefully when appointing this subject to use Abmuza. Abmuza is not recommended in patients with creatinine clearance <15ml/min. Note: The above recommended therapeutic dose for Ambelin is for reference only. Therefore, before using Abmuza, patients need to be prescribed by a doctor.If the patient has missed a dose of Abmuza, use the missed dose as soon as you remember it. However, if the interval between the missed dose of Abmuza and the next dose is close, the patient can skip the missed dose and take the next dose. Patients should also note that it is not recommended to double the dose of Abmuza, because it can cause drug overdose and unwanted side effects that affect the patient's current health.
In case the patient accidentally takes Abmuza drug in excess of the prescribed dose and shows some signs of unwanted side effects, it is necessary to take the patient to the nearest medical facility to receive emergency treatment. timely medical support, helping patients overcome dangerous situations.
4. Unwanted side effects and some notes when using Abmuza
Using Abmuza can cause unwanted side effects such as muscle pain, itching, pain in the arms and legs, rash, trouble breathing, swelling of the face, lips, comb and throat. In case the patient experiences the above symptoms or symptoms such as back pain, numbness or weakness, loss of bladder control, bleeding from the wound, pink/red urine, bloody stools, etc. Take the patient to the emergency room immediately. Although, the side effects mentioned above are not exhaustive, so when using Abmuza, if the patient experiences abnormal signs, immediately contact the doctor for timely medical assistance.
Some notes when using Abmuza:
Do not use Abmuza for patients who are using systemic azole antifungals or protease inhibitors against HIV. These drugs are potent inhibitors of both CYP3a4 and P-gp. Therefore, it is possible that increased plasma concentrations of Abmuza may increase the risk of clinical bleeding. Abmuza should be used with caution in patients with moderate renal impairment. May increase plasma drug concentrations. Similar to other antithrombotic drugs, Abmuza should be used with caution in patients at high risk of bleeding: congenital bleeding disorders, active peptic ulcer disease, retinopathy vascular conjunctivitis, ... Caution should be exercised when the drug is used concomitantly with non-steroidal anti-inflammatory drugs, antiplatelet agents or other antithrombotic drugs. Abmuza medicine can cause fainting, dizziness, so it may affect the process of driving and operating machines. Therefore, the drug should be used with caution in these cases. Abmuza drug can affect the tests to measure the amount of clotting parameters such as PT, APTT, ... due to the influence of the mechanism of action of Abmuza. The drug has not been clinically tested with patients undergoing surgery for hip fractures, so if it is necessary to use it for these subjects, the doctor must have a careful monitoring plan to avoid unwanted side effects. wish could happen. Abmuza should not be used in any case of unexplained hypotension or hypohemoglobinemia, and the site of bleeding must be investigated. Abmuza medicine has ingredients including Rivaroxaban 15mg, which is made in the form of film-coated tablets. The drug belongs to the group of cardiovascular drugs that are effective in the prevention of venous thromboembolism in patients who have undergone major orthopedic surgery of the lower extremities.
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