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The active ingredient Abelcet is amphotericin B lipid complex. The drug belongs to the group of antifungal antibiotics, used to treat invasive fungal infections. To ensure the effectiveness of treatment and avoid side effects, patients need to strictly follow the instructions of the doctor or pharmacist.
1. Uses of the drug Abelcet
Abelcet contains the active ingredient amphotericin B. It is used to treat invasive fungal infections in patients who cannot take other forms of medicine. Abelcet is an antifungal antibiotic with the mechanism of killing fungi, preventing the growth of fungi.
Some other effects of Abelcet are not listed on the drug label, but doctors can prescribe them for some patients' health conditions. Users only use drugs to treat diseases when prescribed by a doctor.
2. Usage and dosage of Abelcet
How to use: Abelcet is used intravenously at the hospital.
Dosage for adults:
Intravenous injection at a dose of 5mg/kg daily, infusion at a dose of 2.5mg/hour; If the patient has renal failure with CrCl < 10 ml/min, a dose of 5 mg/kg should be given every 24 to 36 hours. Dosage for children with systemic fungal infections:
Intravenous injection at a dose of 5mg/kg daily, infusion at a dose of 2.5mg/hour; If the patient has renal failure with CrCl < 10 ml/min, a dose of 5 mg/kg should be given every 24 to 36 hours. Overdose + missed dose: Because the doctor will prescribe and monitor the patient's use of the drug, the case of overdose or missed dose is very rare.
3. Side effects of the drug Abelcet
When using Abelcet, patients may experience some side effects such as: Fever, chills, shaking, flushed skin, loss of appetite, nausea, dizziness, headache, rapid breathing or shortness of breath. These reactions can occur within 1 - 2 hours after starting the drug.
You should tell your doctor if you experience serious side effects such as:
Swelling, pain at the injection site, muscle or joint pain, weakness, muscle cramps, unusual tiredness; warning signs of kidney problems such as change in the amount of urine, pain when urinating; Numbness or itching in the arms/legs, vision or hearing changes (tinnitus); Dark urine, severe stomach or abdominal pain, jaundice, yellow eyes; swollen ankles, fast/slow/irregular heartbeat, blue lips, easy bruising or bleeding, cold sweats; other signs of infection (fever, persistent pain), mood swings, black stools, seizures, coffee-colored vomit; Allergies: Rash, difficulty breathing, severe dizziness,...
4. Precautions when using Abelcet
Before taking Abelcet, the patient should tell the doctor if:
You are pregnant or breast-feeding: Consult a doctor, it is necessary to use the drug exactly as prescribed by the doctor; You are allergic to the ingredients of Abelcet; You are taking other medicines.
5. Drug interactions Abelcet
Some drug interactions of Abelcet include:
Antifungal agents: Anticancer drugs and amphotericin B (a component of the drug Abelcet) may increase the potential for nephrotoxicity, lowering blood pressure and bronchospasm; Corticosteroids and corticotropin (ACTH): Concomitant use of corticosteroids and corticotropin (ACTH) with amphotericin B may increase blood potassium and lead to cardiac dysfunction; Digitalis glycosides: Abelcet may cause hypokalemia and lead to increased digitalis toxicity; Flucytosine: Flucytosine co-administration with Abelcet may increase flucytosine toxicity by promoting cellular absorption and/or decreasing renal excretion; Drugs containing imidazole: Abelcet and imidazole derivatives) such as miconazole and ketoconazole) which are inhibitors of ergosterol synthesis (in the study); Other nephrotoxic drugs: Concomitant use of Abelcet with drugs such as aminoglycosides and pentamidine may increase the potential for nephrotoxicity; Skeletal muscle relaxants: Hypokalemia caused by Abelcet may enhance the effects of curariform in skeletal muscle relaxants; Other drugs: Zidovudine, Cyclosporin A. Before using Abelcet, patients should inform their doctor about the drugs they are taking for advice and appropriate adjustment. During the course of taking the drug, if you experience any adverse side effects, the patient should also notify the doctor immediately.
In summary, the drug Abelcet has the active ingredient amphotericin B lipid complex. The drug belongs to the group of antifungal antibiotics, used to treat invasive fungal infections. To ensure effective treatment and avoid side effects, patients need to strictly follow the instructions of the doctor or pharmacist.
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