This is an automatically translated article.
HIV is a disease of the century with a very high mortality rate. However, the development of many therapeutic drugs has extended the life of patients, one of which is the product Abamune. So what is Abamune L and how is it used?
1. What is Abamune L?
What is Abamune L? Abamune L has active ingredients including Abacavir (as Abacavir Sulfate) 600mg and Lamivudine 300mg. Abamune L is manufactured by Cipla., Ltd of India, circulated in Vietnam with serial number VN3-90-18. Abamune L is in the form of tablets for oral use, packed in a box of 1 vial x 30 pills.
2. What does Abamune L do?
The active ingredients Abacavir and Lamivudine in Abamune L both inhibit the Nucleoside Reverse Transcriptase (NRTI) enzyme. In which Abacavir is the first class of antiretroviral drugs to be deployed.Both active ingredients in Abamune L work by the same mechanism by blocking the action of reverse transcriptase, an enzyme produced by the HIV virus that allows the virus to infect other cells and produce more viruses.
Abamune L should be prescribed in combination with at least one other HIV drug, which reduces the HIV blood load and keeps the HIV load as low as possible.
Note that the drug Abamune L does not completely cure patients of HIV or AIDS, but it can help minimize the damage of the virus to the immune system and limit the risk of developing the disease. development of opportunistic infections and other AIDS-related diseases. The active ingredient Lamivudine in Abamune L is metabolized by both infected and uninfected cells to a triphosphate derivative (TP), which is the active form of Lamivudine when entering the body. However, Lamivudin-TP does not affect deoxynucleotide metabolism in normal cells, it is only a weak inhibitor of mammalian alpha and beta DNA polymerases, so it has little effect on the cellular DNA of mammals. breast.
In the assay for potential effects on mitochondrial structure, DNA composition and function, Lamivudine had no significant toxic effects. Lamivudine has only a very low ability to reduce DNA composition, is not permanently incorporated into mitochondrial DNA, and does not act as an inhibitor of mitochondrial DNA gamma polymerase.
3. Indications and contraindications of Abamune L
Abamune L is indicated in the treatment of HIV infection in adults and children 12 years of age and older for the purpose of strengthening the body's immunity.
However, Abamune L needs to be used in combination with at least one other antiviral drug to treat HIV.
Abamune L is contraindicated in the following cases:
People who have a history of allergies to Abacavir, Lamivudine or any other ingredients in Abamune L; Children under 12 years of age are contraindicated to treatment with Abamune L ; Abamune L should not be used in HIV-infected patients with low neutrophil counts.
4. Dosage and how to use Abamune L
Dosage, how to use Abamune L is recommended as follows:
Adults and children over 12 years old: The recommended dose is 1 tablet of Abamune L each time, 2 times a day; Adjust dose in patients with impaired renal function or severe hepatic impairment.
5. Abamune L . side effects
The most common side effects of Abamune L (occurring with an incidence of 1-10%) include:
Allergic or hypersensitivity reactions; Skin rash; Gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal pain (usually stomach pain); Headache, joint pain; Muscle dysfunction; Cough, nasal symptoms (nose problems, such as irritation and runny nose); Fever; lethargy, lack of energy, fatigue; Insomnia or trouble sleeping; Feelings of discomfort (feeling unwell); Anorexia ; Hair loss;
6. Some issues to pay attention to when using Abamune L
Use Abamune L with caution in the following cases:
Obese women; Patients with liver disease, cirrhosis caused by chronic hepatitis B; Patients with renal failure; The patient is pregnant in the first 3 months of pregnancy and is breastfeeding. In terms of drug interactions, it is necessary to avoid using Abamune L in combination with Ribavirin or Stavudin. Therefore, patients need to inform their doctor about all the products they are taking before starting HIV treatment with Abamune L.
According to the manufacturer's recommendations, Abamune L should be stored in a tightly closed container, stored in a cool, dry place and out of direct sunlight.
In summary, Abamune L has active ingredients including Abacavir (as Abacavir Sulfate) 600mg and Lamivudine 300mg. Abamune L is indicated in the treatment of HIV infection in adults and children 12 years of age and older for the purpose of strengthening the body's immunity. To ensure effective use and avoid unwanted side effects, patients need to take the drug exactly as directed by the doctor or pharmacist.
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