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Mibeproxil 300mg is a drug used in HIV treatment or prevention of HIV infection thanks to its main active ingredient, Tenofovir disoprosil Fumarate.1. What is Mibeproxil 300mg?
What is Mibeproxil 300mg? What is the drug Mibeproxil 300mg with the main active ingredient is Tenofovir disoprosil Fumarate used in the treatment of HIV. This is a chemical substance with a nucleotide diester helix structure similar to adenosine monophosphate. Before being converted to Tenofovir Disoproxil Fumarate must undergo initial diester hydrolysis and convert to tenofovir and then phosphorylate by cellular enzymes. Tenofovir diphosphate is able to inhibit HIV-1 reverse transcriptase activity through competition with the natural substrate deoxyadenosin-5' triphosphate for DNA chain termination.
After entering the body, Tenofovir Disoproxil Fumarate is rapidly absorbed and converted to Tenofovir. The drug is capable of reaching peak plasma concentrations after 1 to 2 hours. Bioavailability of the drug is about 25% and may be increased when taken with a high-fat meal.
2. Indications of the drug Mibeproxil 300mg
Mibeproxil 300mg is indicated for use in the following cases:
Combination therapy with other antiretroviral drugs in the treatment of HIV type 1 (HIV-1) infection in adults without use alone. Combined use with other antiretroviral drugs in the prevention of HIV infection after exposure to occupational disease or without a risk factor for viral infection. Treatment of chronic hepatitis B in adults.
3. How to use Mibeproxil 300mg
For HIV-infected people, use 1 tablet x 1 time/day in combination with other antiretroviral drugs. Prevention of HIV infection after occupational exposure. Best used within a few hours of exposure and continued for the next 4 weeks if tolerated: Take 1 tablet once daily in combination with another antiretroviral agent such as lamivudine or emtricitabine. Prevention of HIV infection without occupational causes is best within 72 hours of exposure and continuously for 28 days: Take 1 tablet x 1 time / day and need to be combined with at least 2 antiretroviral drugs- other viruses. Treatment of chronic hepatitis B: Take 1 tablet x 1 time/day for more than 48 weeks. For patients with renal impairment, the dose should be adjusted based on creatinine clearance. If this index is ≥ 50 ml/min, the usual dose can be used once a day. In the range of 30 - 49 ml/min can be administered every 48 hours and if creatinine clearance is 10 - 29 ml/min then every 72 - 96 hours. For patients undergoing hemodialysis, the dose should be given 7 days apart or 12 hours after dialysis. Patients with impaired liver function do not need to adjust the dose when using Mibeproxil 300mg.
4. Some side effects occur when using Mibeproxil 300mg
In the process of using Mibeproxil, some unwanted side effects may occur such as:
The most common side effects when using Tenofovir Disoproxil Fumarate are mild reactions on the gastrointestinal tract such as diarrhea, nausea, vomiting, abdominal pain, indigestion, flatulence, loss of appetite. Elevated serum amylase levels. Decrease in blood phosphate levels. In rare cases, a skin rash may also occur. There are some reactions on the nervous system such as peripheral neuropathy, headache, insomnia, dizziness, weakness, depression, sweating and myalgia. Increased blood triglyceride levels, increased liver enzymes, increased blood sugar and decreased neutrophils. Mibeproxil may induce adipose tissue proliferation by altering the redistribution or accumulation of body fat. Expressed by the enlargement of the front and back of the neck causing the phenomenon of "buffalo hump", enlargement of the mammary glands. Cushing's syndrome can occur with antiretroviral drugs. When using Tenofovir with Lamivudin and Efavirenz in HIV-infected patients, a decrease in the mineral density of the lumbar spine with an increase in the concentration of 4 biochemical factors in bone metabolism can be observed. Therefore, bone growth should be closely monitored in HIV-infected patients who have a history of fracture or are at risk for osteoporosis.
5. Interactions between Mibeproxil and other drugs:
Tenofovir interacts with drugs that reduce renal function or compete for renal tubular secretion when used at the same time such as acyclovir, cidofovir, ganciclovir, valganciclovir, valacyclovir. These drugs may increase plasma concentrations of tenofovir. Mibeproxil may induce synergism between tenofovir and HIV protease inhibitors such as amprenavir, indinavir, atazanavir, saquinavir, ritonavir. Mibeproxil may induce synergism with nucleoside reverse transcriptase inhibitors such as abacavir, emtricitabine, didanosine, lamivudine, stavudine, zidovudine, zalcitabine. Mibeproxil 300mg is a drug used in HIV treatment or prevention of HIV infection thanks to the active ingredient Tenofovir disoprosil Fumarate. To ensure the effectiveness of treatment and avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
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