Uses of 5-Fluorouracil "Ebewe"

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5 Fluorouracil Ebewe is a drug used for palliative treatment in many types of cancer. To use this drug safely and achieve the best effect, users need to know the information about its use, indications and dosage.

1. 5 What is Fluorouracil Ebewe?


Drug 5 Fluorouracil Ebewe is a pharmaceutical product manufactured by Ebewe Pharma G.m.b.H Nfg. Kg of Austria and imported into Vietnam.
5 Fluorouracil Ebewe belongs to the group of anticancer drugs and acts on the immune system. The drug has the main ingredient Fluorouracil 50mg/ml, which is used for the palliative treatment of some cancers such as: Colon, rectal, stomach and breast cancer ....
Drug 5 Fluorouracil Ebewe is prepared in the form of a strong solution, packed in a box of 1 vial of 5ml, box of 1 vial of 10ml and box of 1 vial of 20ml.

2. Uses of 5 Fluorouracil Ebewe


2.1 Effect of drug components Fluorouracil is a pyrimidine-resistant cytostatic anti-cancer drug. Fluorouracil when entering the body will convert to 5-fluoro-2-deoxyuridine 5'monophosphate (5-FdUMP). This substance competes with deroxyuridinmonophosphate (dUMP), so it inhibits the methylation reaction of desoxyuridilic acid, causing a lack of thymidine for DNA synthesis to kill cancer cells.
2.2 Indications Drugs 5 Fluorouracil Ebewe are often indicated for the treatment of a number of cancers such as:
Colon cancer; Rectal cancer; Breast cancer ; Stomach cancer ; Ovarian Cancer ; Cervical cancer; Bladder cancer; Liver Cancer ; Pancreatic cancer; Head and neck cancer treatment; Stomach cancer . Bile cancer; Kidney cancer . 2.3 Contraindications Drug 5 Fluorouracil Ebewe is not used in the following cases:
Hypersensitivity to Fluorouracil component or drug excipients. The patient has a severe change in the number of blood cells. Liver failure, severe renal failure. People who are suffering from shingles, chickenpox, mouth ulcers, stomatitis or peptic ulcers, pseudomembranous enteritis. Women who are pregnant or breastfeeding. Malnourished patients. Patients with myelosuppression, severe infections. People with DPD (dihydroxypyrimidine dehydrogenase) enzyme deficiency.

3. Usage and dosage


3.1 Administration 5 Fluorouracil Ebewe is prepared as an infusion solution that should be administered by intravenous or intravenous injection. The drug solution will cause irritation when in contact with the skin and mucous membranes. Therefore, only specially trained personnel should open ampoules. When preparing solutions, it should be carried out in a separate place and handled on disposable blotting paper or on a tray with a washable, plastic bottom. Eye protection, masks and disposable gloves should be worn, and disposable gowns should be worn when dispensing medications. Syringe and infusion set must be assembled carefully to prevent leakage. When completing the work, must clean the surfaces in contact with the drug (table top, floor) and wash the face and hands. When the drug is splashed into the eyes, the eyes must be washed with plenty of water and treated with measures. If the drug comes into contact with the skin, wash thoroughly with soap and remove contaminated clothing. If the drug is inhaled or swallowed, immediate treatment measures must be taken. 3.2 Dosage For injection or intravenous infusion:
The drug can be injected or infused intravenously. Dosage is based on the condition of each patient. Dosage can be reduced by 1/3 or 1/2 if the patient's condition is poor, or after major surgery (within 30 days), bone marrow failure (leukopenia, thrombocytopenia, anemia), liver failure and kidney failure.
Initial treatment:
Intravenous infusion: 15mg/kg/day and not more than 1g for 1 infusion. The drug is dissolved in ml of 5% dextrose or 500ml of 0.9% sodium chloride. Infusion rate 40 drops/min for 4 hours or infusion over 30-60 minutes or continuously for 24 hours. The daily dose is administered by successive infusions until toxicity occurs or until 12-15 g is given for a course of treatment. The daily dose should not exceed 1g and between 2 courses should be a break of 4-6 weeks. Intravenous injection: 12mg/kg/day for 3 days. If toxicity does not appear, 6mg/kg/day can be used on day 5, day 7 and day 9. If toxicity occurs, it should be stopped until signs of toxicity subside before taking the next dose. . Maintenance dose: Use 5 - 15 mg/kg. Intravenous injection once a week.
For regional arterial infusion:
Continuous intra-arterial infusion has better results than systemic intravenous administration and also reduces toxicity. The usual dose is from 5-7.5mg/kg/day. Combined with radiation:
Has good efficacy in some types of metastatic lung cancer and has analgesic effect for inoperable recurrences with the usual dose.

4. Side effects


Using the drug 5 Fluorouracil Ebewe may cause some unwanted side effects such as:
Blood: Myelosuppression with leukopenia and neutrophils, immunosuppression and anemia. Gastrointestinal tract: Mucositis, stomatitis, anorexia, pharyngitis, esophagitis, enteritis, gastrointestinal ulceration, gastrointestinal bleeding, malabsorption of food, nausea, vomiting and diarrhea.. Skin: Dry skin, dermatitis, temporary exanthema, photosensitive pruritus, urticaria, baldness, skin pigmentation, acne, skin capillary dilation and skin bleeding. Cardiovascular: Precardiac pain, transient ECG changes, ischemia and myocardial infarction. Nervous system: Drowsiness, euphoria, photophobia, nystagmus, retrobulbar neuritis and CNS dysfunction. Other disorders: Hemolytic anemia, liver damage, kidney failure, hyperuricemia/blood, bronchospasm, anaphylaxis and cough... When experiencing the above-mentioned side effects, please inform the patient. Notify your doctor immediately for prompt treatment.

5. Drug interactions


When 5 Fluorouracil Ebewe is combined with folinic acid, the potency and toxicity of 5-Fluorouracil will increase. If combined with radiotherapy or myelosuppressive agents, the dose of 5-Fluorouracil should be reduced. Combining 5-Fluorouracil with folic acid can cause severe diarrhea. Do not use phenylbutazone, aminophenazone, sulphonamides before and during the use of 5-Fluorouracil. Allopurinol will reduce the potency and toxicity of 5-Fluorouracil. Chlordiazepoxide, griseofulvin, disulfiram, isoniazid will increase the activity of 5-Fluorouracil. Long-term use of 5-Fluorouracil with mitomycin may cause hemolytic uremic syndrome. In order to avoid drug interactions that affect the use of 5-Fluorouracil Ebewe and other drugs being used, patients need to list a list of products they are using and notify the treating doctor for advice and indications. best fit.

6. Caution


5-Fluorouracil Ebewe should only be used under the close supervision of the oncologist and the patient needs to be hospitalized for at least the first course of treatment. During treatment, it is necessary to monitor hematology every 2-3 days. In maintenance treatment, it is necessary to check the blood count, liver function, kidney function, oral cavity regularly before taking the drug. Special care is needed in patients after high-dose pelvic irradiation, or with severe bone metastases. In combination with methotrexate, methotrexate must be administered 24 hours before 5-Fluorouracil is administered. Anti-shock drugs should be prepared because 5-Fluorouracil can cause anaphylactic reactions. Contraceptive measures should be taken before, during, and after the 5-Fluorouracil period. The drug is not used for pregnant women can affect the fetus, do not breast-feed while taking the drug.

7. Treatment of overdose


Using the drug 5 Fluorouracil Ebewe may occur overdose with manifestations such as:
Acute: There are psychotic reactions, increased effects of sedatives, somnolence and increased toxicity of alcohol. Chronic: Bone marrow failure to agranulocytosis, thrombocytopenia, easy bleeding, peptic ulcer, loose stools, and baldness. Anti-toxic measures: Currently, there is still no specific antagonist, so it is necessary to infuse solutions containing leukocytes, platelets and to prevent infection for patients. Concomitant use of appropriate diuretics to balance volume and electrolytes. No dialysis required. If 5-Fluorouracil therapy must be pursued, additional vasodilators should be used to avoid coronary artery spasm. It is necessary to immediately contact a qualified doctor when there are any abnormal signs that suspect Fluorouracil overdose so that the doctor can check and take timely measures.

8. How to store


It is necessary to store the medicine at a temperature below 25 degrees Celsius and avoid direct sunlight. Medicines can be stored in the refrigerator but should not be frozen.
It is necessary to keep the medicine out of the reach and sight of children to prevent children from playing, causing the solution to fall, which will be very dangerous, affecting children.
When the drug is administered, it is necessary to know how to properly dispose of waste. Sharp objects such as needles and syringes must be placed in an appropriate container. Waste syringe solutions should be blotted with cotton and then placed in two sealed polyethylene bags. All disposable vehicles must be placed in plastic bags and all must be incinerated with hospital waste.
Through the information about 5 Fluorouracil Ebewe provided above, hopefully, it has helped everyone to fully understand the drug information. From there, use the drug exactly as prescribed and in the right way to ensure safety and achieve the best effect in treating the disease.

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