Bevacizumab vascular antibiotic therapy in cancer treatment

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Bevacizumab is a vascular antibiotic used to treat certain cancers. Thanks to the development of science and technology, vascular antibiotic therapy with Bevacizumab helps increase the survival time of patients up to 18 - 20 months.

1. What is Bevacizumab?

Bevacizumab is a vascular antibiotic, a man-made antibody (IgG1). With the mechanism of action is to block a certain protein (VEGF), to reduce blood flow to nourish the tumor, thereby slowing the growth of melanoma.
Bevacizumab is prepared in the form of an intravenous solution, with the trade name Avastin, with the concentrations of: 4 ml (100 mg/4 ml) and 16 ml (400 mg/16 ml), respectively.

2. The effect of the drug Bevacizumab

Bevacizumab is used in the treatment of certain cancers such as:
Kidney cancer Cervical cancer Ovarian cancer Colon cancer Rectal cancer Lung cancer (large cell) Certain types of brain tumors One Some types of tumors in the fallopian tubes or peritoneum Thanks to the development of science and technology, vascular antibiotic therapy with Bevacizumab helps to increase the patient's post-treatment survival time up to 18 - 20 months.

3. How is Bevacizumab used?

Depending on the type of cancer, the dose of Bevacizumab will be different. Below are the recommended doses of the drug in the treatment of each specific cancer. However, it should be noted that the first dose of Bevacizumab should be more than 90 minutes. If the patient is well tolerated after the first dose, the second dose of Bevacizumab may take longer than 60 minutes. If the patient tolerates the second dose well 60 minutes after the second dose, subsequent doses may be extended beyond 30 minutes if the patient is able to tolerate it.
3.1 Dosage of Bevacizumab for colon cancer patients
IFL regimen, combined with fluorouracil, irinotecan, leucovorin drugs: Intravenous 5 mg/kg/2 weeks/time. FOLFOX4 regimen, combined with fluorouracil, folinic acid, oxaliplatin: Intravenous 10 mg/kg/2 weeks/time. Chemotherapy regimen if the patient has a good response to the first dose of Bevacizumab, in combination with fluoropyrimidine-irinotecan: Intravenous 5 mg/kg/2 weeks/time; If combined with fluoropyrimidine-oxaliplatin: Intravenous 7.5 mg/kg every 3 weeks. Duration of treatment: Patients are treated until progression or toxicity appears.

3.2 Dosage of Bevacizumab for breast cancer patients
Intravenous 10 mg/kg/2 weeks/time, combined with paclitaxel. 3.3 Bevacizumab dose for ovarian cancer patients
Intravenous 15 mg/kg/3 weeks/time. 3.4 Dosage of Bevacizumab for patients with renal cell carcinoma
Intravenously 10 mg/kg/2 weeks/time, in combination with interferon alfa. 3.5 Bevacizumab drug dosage for patients with large cell cancer
Intravenous infusion 15 mg/kg/3 weeks/time, if treating large cell and non-squamous lung cancer, in combination with carboplatin and paclitaxel. 3.6 Bevacizumab dose for brain cancer patients
Intravenously 10 mg/kg/2 weeks/time. 3.7 Bevacizumab dose for children
Currently, the effect of Bevacizumab in children is not clear. If you have to take medicine, you need a doctor's prescription. However, for pediatric solid tumor patients, the recommended dose is as follows:
Single therapy: Intravenous 15 mg/kg/2 weeks/time. Duration of treatment: 28 days Combination therapy: Intravenous 5 - 10 mg/kg/2 weeks/time.

4. Bevacizumab side effects

Application of vascular antibiotic therapy with Bevacizumab can cause a number of side effects, which are specific in severity and frequency as follows:
Side effects are mild and less serious: Headache , back pain, loss of appetite, diarrhea, sore throat, sneezing, stuffy nose, watery eyes, dry eyes or skin, hair loss, peeling skin, toothache or swelling, gum infection. Side effects occurring during infusion - intravenous injection: headache, dizziness, lightheadedness, nausea, sweating, chest pain, wheezing. Serious but rare side effects that may appear within a few hours of the first dose of Bevacizumab: fatigue, headache, blurred vision, fainting, convulsions, seizures. However, these symptoms may not appear after about 1 year of treatment. In addition, the drug Bevacizumab also causes many serious side effects below:
Hemophilia, non-healing wounds Stomach pain accompanied by symptoms such as high fever, constipation, vomiting Blood in urine and stools Bleeding blood, unusual bruising, body aches, chills, fever Mouth and throat sores Severe headache, vision or language disturbances, numbness or loss of balance Swelling of eyes, abdomen, hands or feet Weight gain Difficulty urinating, Less urine, burning urine, foamy urine Vaginal itching, menstrual disorders

5. Who should be careful when using Bevacizumab?

The following people need to be cautious or not use Bevacizumab :
Have had radiation therapy to the left chest Ever had cancer that has spread to the brain and spine Ever had high blood pressure and heart disease Are pregnant or give Breastfeeding Bevacizumab is a breakthrough vascular antibiotic therapy in cancer treatment that helps slow tumor growth.
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