This is an automatically translated article.
Article by Pharmacist Nguyen Le Trang - Clinical Pharmacist - Pharmacy Department - Vinmec Times City International Hospital
Lenalidomide drug is applied in the treatment of cancer through many mechanisms. This medicine is only used when prescribed by a specialist. Learn the notes when using Lenalidomide through the article below!
1. What is Lenalidomide?
Lenalidomide is an immunomodulatory, vascular antibiotic, anticancer drug through multiple mechanisms. The drug selectively inhibits the secretion of inflammatory cytokines, enhances cell-mediated immunity by stimulating the growth of anti-CD3-stimulating T cells, inhibits nutritional signals with growth factor cell angiogenesis. Inhibits the growth of myeloma and lymphoma cells.
Thuốc Lenalidomide có thể ức chế sự phát triển của tế bào u tủy, lympho
2. Indications and dosage of Lenalidomide
When using Lenalidomide, you need to follow the instructions from your doctor. According to experts, this drug will work best when taken at the same time of day and is not affected by food. Besides, each disease will be assigned a different dose. Specifically:
Recurrent diffuse large B-cell lymphoma: Oral 25 mg/day for 21 days in a 28-day cycle (in combination with tafasitamab) up to 12 cycles. Thereafter, use tafasitamab alone until disease progression or intolerable toxicity is detected. Previously treated follicular lymphoma: 20 mg/day for 21 days of a 28-day cycle (in combination with rituximab) up to 12 cycles Recurrent mantle lymphoma: 25 mg/day for 21 days of a 28-day cycle until disease progression or intolerable toxicity is detected. Previously treated marginal zone lymphoma: 20 mg/day for 21 days in a 28-day cycle (in combination with rituximab) up to 12 cycles Multiple myeloma: 25 mg/day for 21 days in a cycle 28 days (in combination with dexamethasone). In patients without autologous stem cell transplantation, continue treatment until disease progression or intolerable toxicity is detected. In transplant patients, stem cell mobilization should be initiated within 4 cycles of lenalidomide multiple myeloma maintenance after autologous stem cell transplantation: 10 mg/day (started after complete recovery of ANC in bone marrow) 1,000/mm3, , platelets 75,000/mm3, continue until disease progression, dose may be increased to 15mg/day after 3 cycles Newly diagnosed Multiple myeloma: 25mg/day for 21 days cycle 28 day (in combination with darutumumab and dexamethasone) or for a 14-day cycle of 21 days (in combination with bortezomid and dexamethasone) for 8 cycles, followed by maintenance lenalidomide 10 mg/day for 21 days, 28-day cycles for 2 years. Recurrent multiple myeloma: 25 mg/day for 21 days in a 28-day cycle (in combination with carfilzomide/daratumumab and dexamethasone) until disease progression or toxic intolerance is detected.
Thuốc Lenalidomide có thể giúp điều trị bệnh đa u tủy xương
3. Attention when using Lenalidomide
Although Lenalidomide is a cancer treatment, it also has some unwanted side effects. Some risks you may face while taking this medicine such as:
Myelosuppression : The drug causes neutropenia and thrombocytopenia which occurs with a relatively high frequency, monitor total blood cell analysis weekly for 8 first week of treatment and at least monthly thereafter. Thrombotic: Drugs that increase the risk of arterial/venous thromboembolism in patients with multiple myeloma receiving lenalidomide in combination with dexamethasone, consider thromboprophylaxis with aspirin for patients at low thromboembolic risk and enoxaparin for patients at risk. tall muscle. Above is information about Lenalidomide and its risks. Hopefully, the above article has helped you gain more useful knowledge about Lenalidomide to use the drug safely, minimizing possible risks.
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