This is an automatically translated article.
Article translated by Dr. Nguyen Hong Thanh - Researcher, Vinmec High-Tech Center
Guardant Health has launched the Guardant Reveal liquid biopsy test to help detect residual cancer cells and the possibility of recurrence in patients with early colorectal cancer
Guardant Health Inc. A leader in precision oncology research, has announced the release of a liquid biopsy test called the Guardant Reveal TM. In particular, the test uses a blood sample to detect residual cancer cells and the possibility of cancer recurrence through the collection of blood samples. The first commercial trial improved treatment and management for patients with early colorectal cancer (CRC) by detecting residual tumor DNA in the blood. It also improves early detection of tumor cell recurrence compared with current standard of care such as carcinoembryonic antigen (CEA)1-6 testing or imaging.
The Guardant Reveal test is highly sensitive, reaching 91%7 in the detection of freely circulating tumor DNA (ctDNA) by simultaneously identifying changes in gene sequence (variations) and changes in genomic methylation levels. The test accurately identifies the occurrence of variants with allele frequencies of 0.01% and effectively eliminates confounding information such as mutations due to unknown clonal hematopoiesis. The incorporation of epigenomic signatures is essential to increase the sensitivity of the test to detect early-stage cancers, including colorectal cancer. The test gives results within 7 days and requires only a routine blood sample collection without tissue biopsy.
“Colorectal cancer is the second leading cause of cancer death in the United States, and it is estimated that between 10 and 30 percent of cured patients will relapse. Therefore, it is important for physicians to have better tools to manage these patients by rapidly identifying high-risk patients who are likely to have a relapse.” – Helmy Eltoukhy, Director Guardant Health executive said.
Aparna Parikh, Digestive Oncologist at Massachusetts General Hospital and said: “The use of liquid biopsies in clinical practice is a breakthrough approach in improving treatment, management and management. and cancer care for cancer patients at all stages of the disease”. “It is exciting to see that Guardant Health's liquid biopsy tests can not only provide targeted therapies for patients with advanced cancer, but can also detect cancer cells that remain after treatments. surgery and control the risk of recurrence. With this test, clinicians will have a new tool to assess the risk of recurrence in patients with early-stage colorectal cancer, helping to provide adjuvant therapy after surgery. in certain facilities and detect cancer recurrence several months earlier than now."
The Guardant Reveal test is the first commercially available liquid biopsy test for clinical use in the management and treatment of patients with early stage cancer. The test will focus on early-stage colorectal cancer, due to high clinical demand, and will then continue to develop tests for other types of cancer.
Xét nghiệm sinh thiết lỏng Guardant Reveal giúp phát hiện các tế bào ung thư
About Guardant Health
Guardant Health is a leader in precision oncology research, focused on global research programs that aim to find solutions to help conquer cancer through the use of proprietary blood tests, big data sets and advanced analytics. Guardant Health's cancer research platform drives commercial applicability, improves treatment effectiveness, and reduces healthcare costs across all stages of the cancer care continuum. Guardant Health has commercially launched the Guardant360 ®, Guardant360 CDx and GuardantOMNI ® tests based on liquid biopsy for patients with end-stage cancer and Guardant Reveal TM for patients with early-stage cancer. These tests have been the driving force behind the development of the LUNAR screening program, to meet the need for screening and early detection in asymptomatic individuals and those at high risk of developing cancer.
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Reference source: citizentribune
