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Posted by Specialist Doctor II Pham Tien Ngoc - Emergency Doctor - Emergency Department - Vinmec Central Park International General Hospital
Fresh frozen plasma is one of the blood products that are separated from whole blood within 8 hours from the time the blood is removed from the human body and stored frozen. So who are indicated for infusion of fresh frozen plasma?
1. Some indications of fresh frozen plasma
Fresh frozen plasma is separated from donor blood and frozen at -18°C, within 8 hours of blood collection. This fresh frozen plasma (FFP) has a volume of approximately 230ml and can be stored for one year. When thawed, FFP can be stored at 1-6°C for up to 5 days.
Fresh frozen plasma (FFP) is used to replace coagulation factors (should not be used for volume resuscitation). Major indications for FFP include:
Mass blood loss: resuscitation for massive blood loss is optimal when 1 unit of FFP is transfused for every 1-2 units of red blood cells transfused, with a target INR < 1 ,5. Warfarin reversal: FFP (10-15ml/kg) has been used as a substitute for vitamin K-dependent coagulation factors (II,VII,IX,X) in cases of major bleeding associated with antiretroviral therapy. Warfarin coagulation. However, FFP is no longer favored in this setting, possibly because the time required to correct prothrombin time is 12 hours or longer, the volume of fluid required may make bleeding worse, or it may be possible pulmonary edema. Hepatic impairment: FFP can be used to correct prothrombin time in patients with hepatic impairment and uncontrolled bleeding. This therapy is guided by prothrombin time and response is unpredictable.
Huyết tương tươi đông lạnh được bảo quan ở nhiệt độ phù hợp
2. Risks associated with fresh frozen plasma
Some of the risks associated with fresh frozen plasma are as follows:
Urticaria is the most common side effect of FFP infusion (incidence 1:30-100), anaphylaxis (1/20,000) Acute lung injury (1/5000) HIV infection, HBV infection, HCV infection. Freezing eliminates the risk of infection, but does not eliminate the risk of transmitting hepatitis and human immunodeficiency virus, but this rate is very low.
During transfusion of fresh frozen plasma, it is necessary to strictly follow the indications, collect blood, dispense blood and transfuse blood according to the clinical blood transfusion procedure: Transfuse with equipment specifically for blood transfusion, transfuse blood in the correct ABO and Rh groups Closely monitor the patient during and after blood transfusion.
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