This is an automatically translated article.
Prednisolone 5mg is a drug indicated in anti-inflammatory, allergic and immunosuppressive. The drug is mainly used in the treatment of atopic dermatitis, asthma, lupus erythematosus, osteoarthritis, leukemia...
1. What is Prednisolone 5mg?
Prednisolone 5mg is a medicine made in the form of round tablets, indicated in anti-inflammatory, allergic and immunosuppressive for the following diseases:
Atopic dermatitis, asthma, hypersensitivity reactions to drugs . Systemic lupus erythematosus, polymyositis, polymyalgia rheumatica and temporal arteritis, mixed connective tissue disease, acute rheumatoid arthritis. Short-term treatment in the acute, severe phase of rheumatoid arthritis, psoriatic arthritis. Bullous dermatitis, exfoliative dermatitis. Leukemia and lymphoma in adults, acute leukemia in children. Used in the acute phase of ulcerative colitis and Crohn's disease. Granulomatous disease (especially with hypercalcemia), fulminant or diffuse pulmonary tuberculosis when used concomitantly with appropriate chemotherapy. Autoimmune hemolytic anemia, thrombocytopenic purpura. The drug is taken for a short time so there is little risk of sodium retention and edema. The anti-inflammatory effect of Prednisolone 5mg is equivalent to Methyprednisolone 4mg and Hydrocortisone 20mg.
Prednisolone has an approximate half-life of 1.7-2.7 hours, the drug is metabolised in the liver, the substances are metabolized in the form of sulfate esters and glucuronide is excreted in the urine. After 1-2 hours of oral administration, plasma concentrations peak, bioavailability is approximately 82%.
2. Contraindications Prednisolone 5mg
Prednisolone is contraindicated in people with hypersensitivity to any ingredient of the drug, severe infections (except septic shock and tuberculous meningitis), skin infections caused by viruses, fungi or tuberculosis, receiving live viral vaccines.
3. Use Prednisolone 5mg with caution
Some information to note before and during the use of the drug include:
Caution when used for osteoporosis, new anastomosis (intestines, blood vessels), mental disorders, stomach ulcers, duodenal ulcers , diabetes, hypertension, heart failure and growing children, the elderly. Abrupt discontinuation after long-term treatment or in the presence of stress may cause acute adrenal insufficiency. Vaccination efficacy may be affected by high doses of prednisolone. Topical treatment may increase the risk of adrenal suppression in children. Extreme care should be taken when administering Prednisolone to pregnant women. The drug should be used in pregnant women with asthma because of the risk of hypoxia to the fetus and used before premature birth because it can promote lung maturation in the baby. Prednisolone should be used with caution during lactation, as it is still excreted in breast milk, although a very small percentage, in < 1% of the dose. Be careful when driving and operating machinery because it can cause dizziness after taking the drug.
4. Drug interactions
Some possible interactions when taking Prednisolone 5mg with other drugs include:
Do not use with Cyclosporin, Erythromycin, Carbamazepine, Ketoconazole, Rifampicin, Phenytoin, Phenobarbital, hypokalemic diuretics because they reduce blood potassium. potency of Prednisolone. Diabetics taking prednisolone may need a higher dose of insulin because prednisolone can increase blood glucose. Taking with non-steroidal anti-inflammatory drugs can cause stomach ulcers.
5. Side effects of Prednisolone 5mg
Side effects are most likely to occur in people taking high doses and long-term prednisolone. Frequency of side effects are as follows:
Common: Nervousness, insomnia, increased appetite, indigestion, hirsutism, diabetes, joint pain, cataracts, glaucoma, nosebleeds. Uncommon: Dizziness, psychosis, convulsions, headache, delirium, hallucinations, edema, hypertension.
6. Overdose and treatment
An overdose of prednisolone can cause symptoms including Cushing's syndrome, muscle weakness, and osteoporosis. When an overdose occurs, the drug should be temporarily or completely discontinued, continuing to monitor for complications.
7. Usage and dosage of Prednisolone 5mg
Drugs used orally, the dose prescribed varies depending on the age, type and condition of the disease. Dosage according to the manufacturer's recommendations is as follows:
Adults take a dose of 20 - 40 mg/day, acute conditions may require up to 80 mg/day, gradually reduce dose to maintenance dose when symptoms have subsided. The maintenance dose of 5-20mg/day is achieved in 2 weeks after reducing the dose to 5mg/day, 2-3 times/week. Corticosteroids cause growth retardation in infants, children and adolescents, which may be irreversible, so the lowest possible dose should be given for the shortest possible time or as a single dose every other day. Elderly people need to take the lowest effective dose for the shortest amount of time, and long-term use and high doses can increase the risk of serious side effects. The article has provided information about the uses, doses and precautions when using Prednisolone 5mg. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Prednisolone 5mg exactly as directed by your doctor.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
