Precautions while using Amoksiklav

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1. What is Amoksiklav?

Amoksiklav is a product of Lek Pharmaceuticals Company d.d. Amoksiklav 1000mg drug has the main ingredients: 875mg Amoxicillin in the form of Amoxicillin trihydrate and 125mg active ingredient clavulanic acid in the form of potassium Clavulanate (ratio 7:1).

2. What is the use of Amoksiklav medicine?

Amoksiklav 1000mg is indicated for use in the treatment of the following bacterial infections in adults and children:
Treatment of acute bacterial sinusitis (when the condition has been confirmed); Acute otitis media ; Amoksiklav drug for the treatment of acute exacerbations of chronic bronchitis (used when the condition has been confirmed); Treatment of community-acquired pneumonia; Cystitis pathology ; Treatment of nephritis, pyelonephritis; Skin and soft tissue infections, especially cellulitis, animal bites, severe tooth abscesses with diffuse cellulitis; Treatment of bone and joint infections, especially osteomyelitis. It is best that before using Amoksiklav the patient should review the official Amoksiklav instructions on the indications for treatment of the drug.

3. Dosage and how to use Amoksiklav

3.1. Always use Amoksiklav 1000mg exactly as prescribed by the treating doctor Amoksiklav dosage for adults and children weighing 40kg or more:
Usual Amoksiklav dose: 1 tablet, 2 times a day; Amoksiklav dose higher: 1 tablet, 3 times/day; Amoksiklav dose for children weighing <40 kg:
For children 6 years of age and younger, it is best to treat bacterial infections with Amoxicillin / Clavulanic Acid in the form of oral suspension or powder sachets; Use caution and follow the advice of your doctor or pharmacist when administering Amoksiklav 1000mg tablets to children weighing less than 40 kg. Amoksiklav dose for patients with kidney and liver problems:
For patients with kidney problems, the dose of Amoksiklav can be changed: Then the doctor can choose a different dosage or a different drug to treat diseases; Patients with liver problems should have more frequent blood tests to check how well the liver is working during Amoksiklav treatment. 3.2. How to take Amoksiklav pills Take Amoksiklav tablets at the beginning of a meal or near before a meal; Use doses of Amoksiklav equally spaced throughout the day, at least 4 hours apart and do not take 2 doses in 1 hour. Do not take Amoksiklav for more than 2 weeks but still feel unwell, the patient should see a doctor for a re-examination.

4. Contraindications of Amoksiklav

Do not use Amoksiklav in the following cases:
Patients who are allergic (hypersensitive) to Amoxicillin, clavulanic acid, Penicillin or any other ingredient of Amoksiklav 1000mg; The patient has a history of severe allergic reaction (hypersensitivity) to any other antibiotic, symptoms include skin rash or swelling of the face or neck; The patient has had liver problems or jaundice while taking any antibiotic;

5. Side effects of the drug Amoksiklav

The most commonly reported adverse effects of Amoksiklav are diarrhea, nausea and vomiting. Other side effects of Amoksiklav:
Infections/parasites:
Common side effects: Candida infection in mucous membranes; Side effects of unknown frequency: Overgrowth of non-susceptible organisms when taking Amoksiklav. Blood and Lymphatic System Disorders:
Rare side effects include reversible leukopenia (including neutropenia), thrombocytopenia due to Amoksiklav ; Side effects of unknown frequency: Reversible agranulocytosis in patients receiving Amoksiklav, hemolytic anemia, prolongation of bleeding time and prothrombin time. Immune system disorders
Side effects of unknown frequency: Angioedema, anaphylaxis to Amoksiklav, serum sickness-like syndrome, hypersensitivity vasculitis. Nervous system disorders
Uncommon side effects: Dizziness, headache; Side effects of unknown frequency: Reversible hyperactivity, convulsions, aseptic meningitis. Digestive system disorders
Very common side effects: Diarrhea caused by Amoksiklav drug; Common side effects of Amoksiklav: Nausea, vomiting; Uncommon side effects: Indigestion; Unknown side effects frequency: Colitis caused by the use of antibiotics Amoksiklav, black tongue. Hepatobiliary disorders
Uncommon side effects: Increased AST or ALT; Side effects of unknown frequency: Hepatitis, cholestatic jaundice. Skin and subcutaneous tissue disorders
Uncommon side effects: Rash, pruritus, urticaria. Rare side effects: Erythema multiforme. Side effects of unknown frequency: Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative bullous dermatitis, acute generalized pustular syndrome (AGEP). Renal and urinary disorders
Side effects of unknown frequency: Interstitial nephritis ,; Inform the doctor about the unwanted effects patients experience when using Amoksiklav.

6. Caution when using Amoksiklav

During the use of Amoksiklav, the patient should pay attention to the following issues:
Before treatment with Amoksiklav, the patient should carefully check for hypersensitivity reactions to the antibiotics Penicillin, Cephalosporin and other antibiotics. other beta-lactam antibiotics; Convulsions may occur in patients with renal impairment or in patients receiving high doses of Amoksiklav; Avoid taking Amoksiklav if mononucleosis infection is suspected due to the appearance of a measles-like rash after using Amoxicillin; Concomitant use of Allopurinol during treatment with Amoxicillin may increase the risk of allergic skin reactions; Long-term use of Amoksiklav may cause overgrowth of non-susceptible organisms; The appearance of systemic scarlet fever associated with pustules at the start of treatment with Amoksiklav may be a symptom of generalized pustular syndrome (AGEP). At that time, it is necessary to immediately stop the treatment with Amoksiklav and contraindicated the reuse of Amoxicillin; Amoksiklav should be used with caution in patients with evidence of impaired liver function; Antibiotic-associated colitis has been reported with almost all antibiotic classes. Therefore, the diagnosis should be considered in patients presenting with diarrhea during or after antibiotic therapy. If antibiotic-associated colitis, the drug Amoksiklav must be stopped immediately, the use of anti-motility drugs is contraindicated in this case; Periodic assessment of renal, hepatic and hematopoietic function is recommended during prolonged Amoksiklav therapy; In patients with renal impairment, the dose of Amoksiklav should be appropriately adjusted based on the degree of renal impairment; During high-dose Amoxicillin, patients should maintain adequate fluid intake and urine output to minimize the risk of crystalluria; The presence of clavulanic acid in Amoksiklav can cause a false-positive result in the Coombs test; Prophylactic treatment with Amoxicillin/Clavulanic acid may be associated with an increased risk of necrotizing enterocolitis in the neonate, so Amoksiklav should be avoided during pregnancy, unless the benefit is clearly considered by the physician. ; Both active ingredients in Amoksiklav are excreted in breast milk, causing diarrhea and fungal infections in the nursing infant's mucous membranes, which may require stopping breastfeeding. However, Amoxicillin/Clavulanic can still be used during lactation after the risk/benefit has been weighed by the physician.

7. Amoksiklav drug interactions

Possible drug interactions of Amoksiklav are as follows:
Interactions of Amoksiklav with oral anticoagulants: increased international normalized rates of INR in patients maintained on Acenocoumarol or Warfarin with Amoxicillin. If used concomitantly, carefully monitor bleeding time or INR; Methotrexate: Penicillin-class antibiotics may reduce the excretion of methotrexate, increasing the risk of toxicity. Probenecid: Concomitant use of Amoksiklav with Probenecid is not recommended because Probenecid reduces the renal tubular secretion of Amoxicillin which increases and prolongs Amoxicillin blood levels, but has no effect on clavulanic acid concentrations. Amoksiklav 1000mg medicine has the main ingredient Amoxicillin in the form of Amoxicillin trihydrate and 125mg of the active ingredient clavulanic acid in the form of potassium Clavulanate. Amoksiklav 1000mg is indicated for the treatment of bacterial infections.
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