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Newcilotal belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), with the main ingredients being Tramadol and Acetaminophen. The drug has the effect of reducing pain, reducing fever, treating bone and joint diseases, Gout, ...What is Newcilotal?
Newcilotal with Tramadol HCl 37.5mg; Acetaminophen 325mg and excipients are just enough to relieve moderate to severe pain.
Tramadol is a central analgesic. At least two mechanisms occur, binding of parent and active metabolite (M1) to the Mu-opioid receptor and mild inhibition of norepinephrine and serotonin reuptake.
Acetaminophen is another central pain reliever. The exact mechanism and site of its analgesic action are not clearly defined. When evaluated in laboratory animals, the combination of tramadol and paracetamol showed synergistic effects.
Newcilotal is absorbed immediately after oral administration, almost completely and in the small intestine. Peak plasma concentrations of Newcilotal are reached within 1 hour.
About 30% of the drug is excreted in the urine as unchanged drug, while about 60% of the drug is eliminated as metabolites. The major metabolites are demethylation at the N- and O- positions or conjugation with glucuronide or sulfate in the liver.
Indications for the drug Newcilotal
Newcilotal is indicated in the following cases:
Newcilotal is indicated for the treatment of moderate to severe pain. Tramadol ingredients work to help relieve central pain, reduce eye pain, irritation, redness after cataract surgery,... People with flu. Weep. Fever. Pain due to injury or accident. Pain after surgery. Overwork, causing headaches. Musculoskeletal pain
Contraindications of the drug
Newcilotal is contraindicated in the following cases:
Should not be used by nursing women, because there are no studies to ensure the safety of the drug for children and infants. The patient is allergic to any of the ingredients of the drug.
Dosage and how to use Newcilotal
How to use
Take orally.
Dosage
Adults and children over 12 years old: Maximum dose: 1 - 2 tablets / 4-6 hours and not more than 8 tablets in 1 day. Children (under 12 years): Safety and effectiveness have not been studied in children. Elderly (over 65 years): There were no differences in safety or pharmacokinetic properties between users over 65 years of age and younger users.
Newcilotal side effects
The most frequent side effects when taking Newcilotal are:
Central nervous system: nausea, dizziness, drowsiness. Digestive system: nausea. Less common:
Asthenia, fatigue, strong emotions. Peripheral nervous system: headache, tremor. Digestive system: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, dry mouth, vomiting. Psychiatric disorders: anorexia, anxiety, confusion, agitation, insomnia, restlessness. Skin and skin dependent parts: itching, rash, increased sweating. Rare:
Whole body: chest pain, chills, syncope, withdrawal syndrome. Cardiovascular disorders: hypertension, severe hypertension, hypotension. Central nervous system and peripheral nervous system: loss of balance, convulsions, muscle tension, migraine, severe migraine, involuntary muscle contractions, paresthesia, stupor, dizziness. Digestive system: difficulty swallowing, black stools due to gastrointestinal bleeding, tongue edema. Ear and vestibular disorders: tinnitus. Cardiac arrhythmias: arrhythmia, palpitations, tachycardia. Liver and biliary organs: abnormal liver tests. Metabolic and nutritional disorders: weight loss. Psychiatric disorders: forgetfulness, loss of consciousness, depression, substance abuse, mood instability, hallucinations, impotence, nightmares, abnormal ideas. Red blood cell disorders: anemia. Respiratory system: difficulty breathing. Urinary system: albuminuria, urinary disorders, little urine, urinary retention. Visual disturbances: abnormal vision.
Precautions while using Newcilotal
Use caution when using the drug because of the risk of convulsions when tramadol is used concurrently with SSRIs (serotonin reuptake inhibitors), TCAs (tricyclic compounds), Opioids, MAOIs, sedatives or drugs that lower the seizure threshold; or in patients with epilepsy, in patients with a history of seizures, or in patients at risk for seizures. Use with caution, as there is a risk of respiratory depression in patients at risk of respiratory failure; use high doses of Newcilotal with local anesthetics, anesthetics, and alcohol. Caution should be exercised when using Newcilotal concomitantly with drugs that depress the central nervous system such as alcohol, opioids, local anesthetics, anesthetics, hypnotics and sedatives. Newcilotal should be used with caution in patients with increased intracranial pressure or head trauma. Use with caution in patients addicted to opiates, as it can cause relapse. Use with caution in patients with chronic alcoholism because of the risk of hepatotoxicity. For patients with creatinine clearance less than 30 ml/min, a dose of no more than 2 tablets is recommended every 12 hours. Use with caution in patients with severe hepatic impairment. No overdose specified. Do not take with other medicines containing paracetamol or tramadol. Newcilotal belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), with the main ingredients being Tramadol and Acetaminophen. The drug has the effect of reducing pain, reducing fever, treating bone and joint diseases, Gout, ... To ensure effective treatment and avoid unwanted side effects, patients need to take the drug according to the doctor's instructions. specialist doctor and pharmacist.
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