What is Celebrex 200mg and how does it work?

This is an automatically translated article.

Celecoxib medicine 200mg has the main ingredient is Celecoxib and other excipients. This is a non-steroidal anti-inflammatory drug belonging to the group of antipyretic, analgesic, anti-inflammatory drugs. The drug is effective in the treatment of musculoskeletal disorders.

1. What is Celebrex 200mg?

Celebrex medicine 200mg belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs or NSAIDs. The drug is widely used in the treatment of bone and joint diseases such as rheumatoid arthritis, osteoarthritis.

2. What does Celebrex do?

Celebrex is a non-steroidal anti-inflammatory drug (NSAID). Unlike other active ingredients, Celecoxib has a selective inhibitory effect on the enzyme Cyclooxygenase 2 (COX-2). This is an enzyme that responds to an inflammatory agent. Since then, the drug works in preventing the synthesis of Prostaglandin E2, the main cause of inflammation, pain, swelling and edema. Because it does not affect the COX-1 enzyme, all physiological processes related to this enzyme in the gastric mucosa, intestines, and platelets are not affected. This means that Celecoxib does not cause as many unwanted effects as both COX-1 inhibitors. Clinical studies show that the drug is effective in the treatment of diseases such as rheumatoid arthritis, osteoarthritis, pain, ankylosing spondylitis...

3. Undesirable effects of drugs

Common undesirable signs when taking the drug:
Digestive disorders: abdominal pain, bloating, flatulence, indigestion, nausea, vomiting, diarrhea; Effects on the respiratory system: pharyngitis, nasopharyngitis, sinusitis or upper respiratory tract infection; Effects on the central nervous system such as sleep disturbance, dizziness, headache; Increased blood pressure, myocardial infarction; Rash, rash on the surface of the skin; Back pain; Appears signs and symptoms similar to the flu; Peripheral edema. Rare adverse effects when using the drug:
Cerebrovascular accident, congestive heart failure, ventricular fibrillation, pulmonary embolism, thrombophlebitis and vasculitis. Gastrointestinal bleeding, intestinal obstruction, gastric perforation, bleeding colitis, esophageal perforation, pancreatitis. Gallstone disease, jaundice, hepatitis and hepatocellular failure. Thrombocytopenia, agranulocytosis, pancytopenia, aplastic anemia, and leukopenia. Reduce blood sugar levels. Ataxia, psychological abnormalities such as paranoia, and possibly suicidal thoughts. Acute renal failure, interstitial nephritis. Appears erythema multiforme, dermatitis, exfoliative. Infection, angioedema. Instructions on how to manage adverse effects are as follows:
If signs of renal toxicity are observed, the patient should stop taking the drug immediately, usually renal function will return to pre-treatment levels after treatment. stop using the drug.
Liver cell function test: Liver enzyme levels can be up to 3 times higher than normal at the upper limit. This elevation of liver enzymes may be progressive or unchanged or only temporary for a while with continued treatment. However, if there is a serious manifestation of hepatitis such as jaundice, the drug should be stopped immediately.

4. Indications to use Celebrex 200mg

Indications to use Celebrex 200mg in the following cases:
Treatment of degenerative diseases and rheumatoid arthritis in adults. Juvenile idiopathic arthritis in children 2 years of age and older with a weight of at least 10 kg. Ankylosing spondylitis; Acute pain during and after trauma and surgery. Persistent pain in chronic conditions such as cancer; Primary dysmenorrhea in women.

5. Contraindications to taking Celebrex 200mg

Celebrex 200mg drug should not be used in the following cases:
People who are hypersensitive or sensitive to any of the ingredients in the drug. People with a history of allergy to Sulfamid. People with a history of asthma, urticaria, allergic reactions to Aspirin and active ingredients of the NSAID group. People with severe liver failure. Use with caution in the following subjects:
People with a history of cardiovascular diseases because Celecoxib has an increased risk of thrombosis, myocardial infarction, stroke, hypertension or cardiac edema. People with a history of peptic ulcer disease, especially in the elderly. People with kidney failure caused by NSAIDs are nephrotoxic. People with dehydration or electrolyte disorders. People who are taking oral anticoagulants.

6. Route and dose of Celebrex 200mg

How to use the drug as follows:
Take the whole Celebrex 200mg tablet with a full glass of water, especially for people who have difficulty swallowing can crush the tablet with smoothie to drink. It can be taken before, during or after a meal because food does not affect the absorption of the drug. Do not use drugs that are moldy and expired on the packaging. Dosage:
Do not arbitrarily use Celebrex 200mg without a doctor's prescription. At the same time, when treating, you need to follow all instructions in the prescription, you can refer to the following dosage:
Adults:
Osteoarthritis: 1 pill/time/day. Treatment of rheumatoid arthritis: 1 tablet / time, 2 times / day. Ankylosing spondylitis: 1 tablet / time / day, some people respond well to the drug, the dose is 2 tablets / day. Acute pain relief: The first day take 2 tablets / time, the next days take 1 tablet / time. Primary dysmenorrhea: The usual dose is 2 tablets / time, in the first day of the cycle can take 3 tablets / time. Children with idiopathic arthritis:
Children from 2-12 years old: Only use the drug with a small amount of preparations such as 50 mg and 100 mg capsules to make it easier to divide the dose during the day. Children from 12 to 17 years old: Suitable for treatment with Celebrex 200mg, 1 tablet per day. You also need to pay attention to some warning signs of drug overdose as follows:
An overdose of celecoxib can cause the following conditions: lethargy, lethargy, drowsiness, nausea, vomiting, and burning pain. epigastric. Gastrointestinal bleeding such as black stools, vomiting blood. Manifestations occur with very low frequency such as hypertension, acute renal failure, respiratory depression and coma. Anaphylactoid reactions have been reported with therapeutic doses of celecoxib and may occur with overdose. Treatment for drug overdose is as follows:
Currently, there is still no specific antidote for this condition. However, when a drug overdose, doctors will focus on treating symptoms first. In the first 4 hours after an overdose can be treated:
Emetic therapy; Use activated charcoal with a content of 60-100g for adults or 1-2g/kg for children; Using osmotic bleach can be effective for patients who already have a medical condition or have taken too large a dose of Celebrex 200mg.

7. Interactions of Celebrex 200mg

When using Celecoxib simultaneously with the following substances may cause interactions:
Warfarin, Heparin: increased risk of bleeding. Lithium: Increased concentration and toxicity of lithium. NSAIDs: Increased unwanted effects on the body. Antihypertensive drugs including ACE inhibitors, diuretics: Reduce the antihypertensive effect. Dextromethorphan, Metoprolol: The active ingredient Celecoxib may increase plasma concentrations of these substances. Reduces the effectiveness of oral contraceptives. Tell your treating doctor about all medications you are taking to review interactions and assess the benefits and risks of taking them.

8. Notes on treatment with Celebrex 200mg

Use on pregnant and lactating women
The drug has a risk of reducing the ability to ovulate and conceive in women who are trying to become pregnant. Therefore, it is necessary to consider discontinuing the use of this drug. Like other NSAIDs, Celecoxib causes premature closure of the ductus arteriosus, decreases uterine muscle tone, and causes preterm labor and labor difficulties in women in the third trimester of pregnancy. Therefore, the drug should not be used in pregnant women during this period. It has been reported that the drug is excreted in breast milk and causes potential undesirable effects in the infant. The doctor will decide to take the medicine after weighing the benefits for the mother and the risks for the baby. Drivers and machine operators: Currently, there are no data on the harmful effects of the drug on the ability of workers to drive and work. Therefore, the treating doctor can still consider drug treatment for this subject.
About storage conditions:
Celebrex 200mg capsules are stored in a tight cover, avoiding tearing and moisture. Store the medicine at a temperature below 30 degrees Celsius, in a cool, dry place. When crushed and mixed with smoothies, it can be stored for about 6 hours in the refrigerator with a temperature of 2-8 degrees Celsius. After that time, you should throw away the medicine if you do not use it. Keep medicine out of reach of children. Celebrex 200mg drug belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs or NSAIDs. The drug is widely used in the treatment of musculoskeletal disorders. To ensure effective treatment and avoid side effects, patients need to take medicine according to prescription, or consult a doctor or pharmacist for advice.
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