Nevirapine (NVP) 1st line ARV side effects

This is an automatically translated article.

The article was written by Doctor, Dr. Le Xuan Luat - Infectious, hepatobiliary doctor - Department of General Internal Medicine, Vinmec Times City International General Hospital.
Nevirapine was approved for use in 1996 in the US. Nevirapine belongs to the class of non-nucleotide reverse transcriptase inhibitors (NNRTIs). After the HIV virus enters the host cell, the HIV RNA strand is released, and the single strand RNA is reverse transcribed to form DNA by reverse transcriptase. The drug inhibits the formation of DNA, reduces the amount of HIV virus.

1. First-line ARV regimens

Table 1: First-line ARV regimens
Table 2: Symbols of ARV drug names

2. Nevirapine (NVP) 1st line ARV side effects

Rash The most common side effect of Nevirapine is a rash. The incidence of mild rash in nevirapine users can be as high as 50%. Nevirapine users may develop a rash at any time during the first 4-6 weeks of taking the drug. The first 10 days of taking the drug is the time when the rash is most common. The rash may appear slowly and spread to the whole body. The rash can be mild to severe, ranging from erythema, papule, vesicular vesicles, mucosal lesions of natural cavities.
Liver damage NVP causes liver damage to varying degrees. NVP users need periodic liver enzyme monitoring. If liver enzymes are elevated above 5 times normal, consideration should be given to discontinuing NVP.

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