Maprotiline HCL: Uses, indications and precautions when using

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Maprotiline HCL is used to treat many types of depression and anxiety conditions. Medicines can help improve mood and create feelings of happiness. Maprotiline HCL belongs to the group of tetracyclic antidepressants. Maprotiline affects the balance of certain neurotransmitters in the brain.

1. Indications and contraindications of the drug Maprotiline HCL

Maprotiline HCL is indicated in the following cases:
Anxiety related to depression Depression Maprotiline HCL is contraindicated in the following cases:
Hyperthyroidism Low neutrophil level Manic depression Thoughts suicide Alcoholism Glaucoma Angle-closure glaucoma A heart attack within the last 30 days Sinus tachycardia Abnormal heartbeat Abnormal ECG with QT changes since birth. Stroke Decreased lung function Liver disease Convulsions Urinary incontinence

2. How to use Maprotiline HCL

Carefully read the medication instructions provided by your doctor before you start taking Maprotiline HCL and each time you are given a refill. If you have any questions about how to use Maprotiline HCL, consult your doctor.
Take Maprotiline HCL by mouth, usually 1 to 3 times daily or as directed by your doctor. If you only take it once a day, take it before bed to reduce daytime sleepiness. The dose of Maprotiline HCL is calculated by your doctor based on your medical condition and response to treatment.
To reduce your risk of Maprotiline HCL side effects such as drowsiness, dry mouth, or dizziness, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's orders carefully.
Take Maprotiline HCL regularly to get the most benefit from it. To avoid forgetting to take your medication, take it at the same time(s) each day. Do not increase your dose or use Maprotiline more often or for longer than prescribed by your doctor. Doing so will not help your condition improve faster, but it will also increase your risk of side effects from the medication.
Continue taking Maprotiline HCL even if you feel well. Do not stop taking the medicine without consulting your doctor. Some conditions may get worse when Maprotiline HCL is stopped suddenly. In addition, you may experience other symptoms such as mood swings, headaches, and fatigue. To prevent these symptoms while you stop treatment with this medicine, your doctor may reduce your dose gradually.
Maprotiline HCL may not work right away. You may see some benefit within a week. However, it may take up to 3 weeks before you feel the full effect from the medicine.
Tell your doctor if your condition persists or gets worse (such as feelings of sadness getting worse or you have suicidal thoughts) after using Maprotiline HCL.

3. Side effects of the drug Maprotiline HCL

While using Maprotiline HCL, you may feel drowsy, dizzy, dry mouth, blurred vision, constipation or difficulty urinating. If any of these side effects persist or worsen, notify your doctor immediately.
To reduce the risk of dizziness and lightheadedness when using Maprotiline HCL, get up slowly when getting up from a sitting or lying position.
To relieve dry mouth while taking Maprotiline, you can suck on hard candy (sugar-free) or shaved ice, chew gum (sugar-free), drink water, or use a saliva substitute.
To prevent constipation, eat enough fiber, drink enough water and exercise. You may also need to take a laxative when the above measures don't work.
Remember that your doctor gave you this medicine because he or she has judged that the benefit to you is greater than the risk of side effects. Many people use Maprotiline HCL and no serious side effects occur.
Tell your doctor right away if any of these rare but serious side effects of Maprotiline HCL occur: persistent heartburn, mental/mood changes (such as anxiety, agitation, confusion), shaking, severe stomach or abdominal pain.
Get medical help right away if you have any very serious side effects of Maprotiline HCL, including: Severe dizziness, fast/irregular heartbeat, fainting, seizures, sore eyes /swelling/redness, dilated pupils, changes in vision.
A very serious allergic reaction to Maprotiline HCL has very rarely occurred. However, if you notice any symptoms of a serious allergic reaction to Maprotiline HCL, including: rash, itching/swelling (especially of the face/tongue/throat), trouble breathing, dizziness serious, seek immediate medical attention.
Below are the Maprotiline HCL side effects by likelihood.
Common side effects of Maprotiline HCL include:
Allergic Dermatitis Erythema Itching Skin Rash Angioedema Change in sexual interest Blurred vision Dry mouth Inability to get an erection Dizziness Headache Less common side effects of Maprotiline HCL include:
Excitement Convulsions Muscle tremors Weight loss Nausea Vomiting Constipation Skin increased sensitivity to sunlight Difficulty sleeping Excessive sweating Weight gain Increased hunger heartburn Digestive disease Diarrhea Rare side effects of Maprotiline HCL include:
Very low level of granulocytes Confusion Suicidal thoughts Serotonin syndrome High blood pressure QT interval prolongation on ECG Abnormal heartbeat Low blood pressure Testicle swelling Breast enlargement Breast milk production unrelated to childbirth or breastfeeding Hallucinations Low energy Difficult or painful urination Secondary angle-closure glaucoma Yellowing of the eyes or skin due to bilirubin accumulation Tachycardia Fainting Heart palpitations This is not a complete list of the possible side effects of Maprotiline HCL. If you notice other side effects of Maprotiline HCL not listed above, contact your doctor right away.

4. Measures to prevent side effects of the drug Maprotiline HCL

Before taking Maprotiline HCL, tell your doctor if you are allergic to this medicine or tricyclic antidepressants (such as Nortriptyline) and any other allergies if any. Maprotiline products may contain ingredients that do not work and that may cause allergic reactions or other problems.
Before using Maprotiline HCL, tell your doctor your medical history, especially of: Bleeding problems, breathing problems, kidney problems, liver problems, recent heart attack, urination problems, hyperthyroidism, personal or family history of glaucoma (angle-closure type), personal or family history of mental/mood conditions ( such as bipolar disorder, psychosis), family history of suicide, epilepsy, conditions that may increase the risk of seizures (such as encephalopathy, alcohol/sedation withdrawal) ).
Maprotiline can cause QT prolongation, however this condition can rarely cause potentially fatal tachycardia/irregular heartbeat and other symptoms such as severe dizziness, fainting need immediate medical attention.
Maprotiline HCL can make you dizzy, drowsy, or blurred your vision, and alcohol and marijuana can make you more dizzy or drowsy. Do not drive, use machines, or do anything that requires alertness or clear vision while using Maprotiline, until you can do so safely.
Before surgery, tell your doctor or dentist that you are being treated with Maprotiline HCL.
Maprotiline may make you more sensitive to the sun. Limit your time in the sun, use sunscreen, and wear protective clothing when outdoors.
If you have diabetes, Maprotiline HCL medicine may make it harder for you to control your blood sugar. Monitor your blood sugar regularly and let your doctor know the results. Your doctor may need to adjust your diabetes medication dose, exercise program, or diet.
Older adults may be more sensitive to the side effects of Maprotiline HCL, especially dizziness (which is more likely to happen when standing up), drowsiness, dry mouth, confusion, constipation, difficulty urinating, and pulling. QT length (see above). Dizziness, drowsiness, and confusion may increase the risk of falls in the elderly.
For women during pregnancy, Maprotiline should only be used when clearly needed. However, because untreated mental/mood problems (such as depression) can be a serious condition, do not stop using Maprotiline unless directed by your doctor. If you are planning a pregnancy, are pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using Maprotiline during pregnancy.
Maprotiline passes into breast milk and the effect on a newborn baby is unknown. Women who are breast-feeding should consult their doctor before using the drug.

5. Maprotiline HCL drug interactions

Drug interactions can change the way Maprotiline HCL works or increase your risk of serious side effects. Tell your doctor about all the medicines you take (including prescription/nonprescription drugs and herbal products). Do not start, stop, or change the dose of any medication while using Maprotiline HCL, without your doctor's approval.
Some products that may interact with Maprotiline HCL include: Arbutine, thyroid hormone supplements, anticholinergics (such as belladonna alkaloids), centrally acting drugs to treat high blood pressure (such as clonidine, guanabenz). , guanadrel, methyldopa).
Taking an MAO inhibitor with Maprotiline HCL can cause serious drug interactions that can even be fatal. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medicine. Most MAO inhibitors are also not recommended for two weeks prior to treatment with Maprotiline HCL.
Other drugs can affect the removal of maprotiline from your body, thereby affecting how maprotiline works. These medications include cimetidine, terbinafine, drugs for irregular heartbeats (such as quinidine/propafenone/flecainide), and antidepressants (such as SSRIs including paroxetine/fluoxetine/fluvoxamine).
Many drugs other than maprotiline can affect heart rate (QT prolongation in electrocardiogram), including amiodarone, cisapride, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), and some other types.
Tell your doctor if you are taking other products that also cause drowsiness, including alcohol, marijuana, antihistamines (such as cetirizine, diphenhydramine), sleeping or anti-anxiety medications (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine).

6. What to do when overdose or forget to take Maprotiline HCL?

If you or someone else has overdosed on Maprotiline HCL and has severe symptoms such as fainting or difficulty breathing, call 911 immediately. Maprotiline overdose symptoms may include: Extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow breathing, seizures.
Tests such as complete blood count, liver function tests, electrocardiogram, and blood pressure measurement may be done from time to time to monitor your progress or check for side effects while using Maprotiline. HCL.
If you miss a dose of Maprotiline HCL, take it as soon as you remember. If you remember when it is almost time for your next dose, skip the missed dose. Use your next dose of Maprotiline HCL at the usual time, do not double the usual dose.

7. How to store the drug Maprotiline HCL

Store Maprotiline HCL at room temperature from 68-77 degrees F (20-25 degrees C), away from light and moisture, do not leave in the bathroom. Keep Maprotiline HCL out of reach of children and pets. Dispose of this medication appropriately when it expires or it is no longer needed by you.

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Reference source: webmd.com